Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients

Blood

Volumn 91, Issue 10, 1998, Pages 3562-3565

  De Stefano, Valerio ^a   Chiusolo, Patrizia ^b   Paciaroni, Katia ^b   Casorelli, Ida ^b   Rossi, Elena ^b   Molinari, Marco ^b   Servidei, Serenella ^b   Tonali, Pietro A ^b   Leone, Giuseppe ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTHROMBIN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CHILD; CLINICAL ARTICLE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HOMOZYGOTE; HUMAN; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; VEIN THROMBOSIS;

EID: 0032525101     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.10.3562     Document Type: Article

References (12)

1. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM: A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88: 3698, 1996
2. Hillarp A, Zoller B, Svensson PJ, Dahlback B: The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost 78:990, 1997
3. Cumming AM, Keeney S, Salden A, Bhavnani M, Shwe KH, Hay CRM: The prothrombin gene G20210A variant: Prevalence in a U.K. anticoagulant clinic population. Br J Haematol 98:353, 1997
4. Corral J, Gonzalez-Conejero R, Lozano ML, Rivera J, Heras I, Vicente V: The venous thrombotic risk factor 20210 A allele of the prothrombin gene is not a major risk factor for arterial thrombotic disease. Br J Haematol 99:304, 1997
5. Doggen CJM, Visser T, Bertina RM, Manger Cats V, Rosendaal FR: Prothrombin 20210 G→A as a moderate risk factor for myocardial infarction. Thromb Haemost 77:379, 1997 (abstr, suppl)
6. Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL: A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 90:1747, 1997
7. Martinelli I, Franchi F, Akwan S, Bettini P, Merati G, Mannucci PM: The transition G to A at position 20210 in the 3′-untranslated region of the prothrombin gene is not associated with cerebral ischemia. Blood 90:3806, 1997 (letter)
8. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64, 1994
9. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R: A candidate genetic risk factor for vascular disease: A common mutation in methylene tetrahydrofolate reductase. Nat Genet 10:111, 1995
10. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH: High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85:1504, 1995
11. Scott CM, Hanley JP, Ludlam CA, Stirling D: Homozygosity for a factor II polymorphism associated with thrombosis during pregnancy. Thromb Haemostas 77:770, 1997 (abstr, suppl)
12. Brickner ME: Cardioembolic stroke. Am J Med 100:465, 1996