Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway

Oncogene

Volumn 18, Issue 30, 1999, Pages 4313-4325

  Rousseau, Denis ^a   Cannella, Dominique ^a   Boulaire, Jerome ^a   Fitzgerald, Patrick ^b   Fotedar, Arun ^b   Fotedar, Rati ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

CDK; Cell cycle; p21(WAF1 CIP1); PCNA; Proteasome; Ubiquitination

Indexed keywords

CYCLINE; DNA; MUTANT PROTEIN; PROTEASOME; PROTEIN P21; UBIQUITIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; DNA SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY;

3T3 CELLS; ACETYLCYSTEINE; ANIMALS; CDC2-CDC28 KINASES; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH INHIBITORS; HEMAGGLUTININS; HUMANS; LEUPEPTINS; MICE; MODELS, GENETIC; MULTIENZYME COMPLEXES; MUTAGENESIS; OSTEOSARCOMA; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; UBIQUITINS;

EID: 0033615003     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202686     Document Type: Article

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