Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression

Molecular and Cellular Biology

Volumn 17, Issue 3, 1997, Pages 1065-1074

  Bradford, Andrew P ^a   Wasylyk, Christine ^b   Wasylyk, Bohdan ^b   Gutierrez Hartmann, Arthur ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b CNRS   (France)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HOMEODOMAIN PROTEIN; PROLACTIN; THYROTROPIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; DNA BINDING; GENE EXPRESSION; HOMEOBOX; HUMAN; HUMAN CELL; HYPOPHYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; SOMATIC CELL; STEM CELL;

ANIMALIA;

EID: 0031037986     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.3.1065     Document Type: Article

References (58)

1. Barta, A., R. Richards, J. Baxter, and J. Shine. 1981. Primary structure and evolution of rat growth hormone gene. Proc. Natl. Acad. Sci. USA 78:4867-4871.
2. Boulukos, K., P. Pognonec, B. Rabault, A. Begue, and J. Ghysdael. 1989. Definition of an Ets-1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro. Mol. Cell. Biol. 9:5718-5721.
3. Bradford, A. P., K. E. Conrad, C. Wasylyk, B. Wasylyk, and A. Gutierrez-Hartmann. 1995. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain. Mol. Cell. Biol. 15:2849-2857.
4. Bradford, A. P., K. E. Conrad, P. H. Tran, M. C. Ostrowski, and A. Gutierrez-Hartmann. 1996. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J. Biol. Chem. 271:24639-24648.
5. Brunner, D., K. Ducker, N. Oellers, E. Hafen, H. Scholz, and C. Klambt. 1994. The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway. Nature 370:386-389.
6. Camper, S., Y. Yao, and F. Rottman. 1985. Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells. J. Biol. Chem. 260: 12246-12251.
7. Conrad, K. E., and A. Gutierrez-Hartmann. 1992. The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity. Oncogene 7:1279-1286.
8. Conrad, K. E., J. M. Oberwetter, R. Vallaincourt, G. L. Johnson, and A. Gutierrez-Hartmann. 1994. Identification of the functional components of the Ras signaling pathway regulating pituitary cell-specific gene expression. Mol. Cell. Biol. 14:1553-1565.
9. Delhase, M., V. Vila, E. L. Hooghe-Peters, and J. L. Castrillo. 1995. A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/Pit-1 gene. Gene 155:273-275.
10. Dolle, P., J. L. Castrillo, L. E. Theill, T. Deerinck, M. Ellisman, and M. Karin. 1990. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell 60:809-820.
11. Donaldson, L., J. Petersen, B. Graves, and L. McIntosh. 1994. Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn-helix DNA-binding proteins. Biochemistry 33:13509-13516.
12. Donaldson, L., J. Petersen, B. Graves, and L. McIntosh. 1996. Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA-binding motif. EMBO J. 15:125-134.
13. Elsholtz, H. P. 1992. Molecular biology of prolactin: cell-specific and endocrine regulators of the prolactin gene. Semin. Reprod. Endocrinol. 10:183-195.
14. Elsholtz, H. P., A. M. Lew, P. R. Albert, and V. C. Sundmark. 1991. Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. J. Biol. Chem. 266:22919-22925.
15. Engel, J., H. Beug, J. LaVail, M. Zenke, K. Mayo, M. Leonard, K. Foley, Z. Yang, J. Kornhauser, L. Ko, K.-C. Lim, K. George, and K. Breigel. 1992. Cis and trans regulation of tissue-specific transcription. J. Cell Sci. Suppl. 16: 21-31.
16. Feig, L., and G. M. Cooper. 1988. Inhibition of NIH 3T3 cell proliferation by a mutant Ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235-3243.
17. Gehring, W. J. 1987. Homeoboxes in the study of development. Science 236:1245-1252.
18. Giovane, A., A. Pintzas, S.-M. Maira, P. Sobieszcuk, and B. Wasylyk. 1994. Net, a new ets transcription factor that is activated by Ras. Genes Dev. 8:1502-1513.
19. Gourdji, D., and J.-N. Laverriere. 1994. The rat prolactin gene: a target for tissue-specific and hormone-dependent transcription factors. Mol. Cell. Endocrinol. 100:133-142.
20. Grueneberg, D., K. Simon, K. Brennan, and M. Gilman. 1995. Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins. Mol. Cell. Biol. 15:3318-3326.
21. Grueneberg, D. A., S. Natesan, C. Alexandre, and M. Z. Gilman. 1992. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 257:1089-1095.
22. Gutierrez-Hartmann, A. 1994. Pit-1/GHF-1: a pituitary-specific transcription factor linking general signaling pathways to cell-specific gene expression. Mol. Endocrinol. 8:1447-1449.
23. Gutierrez-Hartmann, A., S. Siddiqui, and S. Loukin. 1987. Selective transcription and DNase I protection of the rat prolactin gene by GH3 pituitary cell-free extracts. Proc. Natl. Acad. Sci. USA 84:5211-5215.
24. Harvey, C., S. M. Jackson, S. K. Siddiqui, and A. Gutierrez-Hartmann. 1991. Structure-function analysis of the rat prolactin promoter: phasing requirements of proximal cell-specific elements. Mol. Endocrinol. 5:836-843.
25. Haugen, B., M. McDermott, D. Gordon, C. Rupp, W. Wood, and E. Ridgway. 1996. Determinants of thyrotroph-specific thyrotropin β promoter activation: cooperation of Pit-1 with another factor. J. Biol. Chem. 271:385-389.
26. Haugen, B. R., D. F. Gordon, W. W. Wood, and E. C. Ridgway. 1994. The combination of Pit-1 and Pit-1T have a synergistic stimulatory effect on the thyrotropin β subunit promoter but not the growth hormone or prolactin promoters. Mol. Endocrinol. 8:1574-1582.
27. Haugen, B. R., W. M. Wood, D. F. Gordon, and E. C. Ridgway. 1993. A thyrotroph-specific variant of Pit-1 transactivates the thyrotropin β promoter. J. Biol. Chem. 268:20818-20824.
28. Hayashi, S., and M. Scott. 1990. What determines the specificity of action of Drosophila Homeodomain proteins? Cell 63:883-894.
29. Herr, W., and M. Cleary. 1995. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9:1679-1673.
30. Hill, C., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanism and specificity. Cell 80:199-211.
31. Howard, P., and R. Maurer. 1995. A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways. J. Biol. Chem. 270:20930-20936.
32. Iverson, R. A., K. H. Day, M. d'Emden, R. N. Day, and R. A. Maure. 1990. Clustered point mutation analysis of the rat prolactin promoter. Mol. Endocrinol. 45:1564-1571.
33. Jackson, S. M., C. A. Keech, D. J. Williamson, and A. Gutierrez-Hartmann. 1992. Interaction of positive and negative transcription elements controls repression of the proximal rat prolactin promoter in nonpituitary cells. Mol. Cell. Biol. 12:2708-2719.
34. Janknecht, R., and A. Nordheim. 1993. Gene regulation by Ets proteins. Biochim. Biophys. Acta 1155:346-356.
35. Karin, M., L. Theill, J. L. Castrillo, A. McCormick, and H. Brady. 1990. Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1. Recent Prog. Horm. Res. 46:43-57
36. Keech, C. A., and A. Gutierrez-Hartmann. 1989. Analysis of rat prolactin promoter sequences that mediate pituitary-specific and 3′,5′-cyclic: adenosine monophosphate-regulated gene expression in vivo. Mol. Endocrinol. 3:832-839.
37. Konzak, K. E., and D. D. Moore. 1992. Functional isoforms of Pit-1 generated by alternative mRNA splicing. Mol. Endocrinol. 6:241-247.
38. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski. 1992. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol. Cell. Biol. 12:5355-5362.
39. Macleod, K., D. Leprince, and D. Stehelin. 1992. The ets gene family. Trends Biochem. Sci. 17:251-256.
40. Mohammadi, M., I. Dikic, A. Sorokin, W. H. Burgess, M. Jaye, and J. Schlessinger. 1996. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16:977-989.
41. Morris, A. E., B. Kloss. R. E. McChesney, C. Bancroft, and L. A. Chasin. 1992. An alternatively spliced Pit-1 isoform altered in its ability to transactivate. Nucleic Acids Res. 20:1355-1361.
42. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins. Science 261:82-86.
43. O'Neill, E. M., I. Rebay, R. Tjian, and G. M. Rubin. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
44. Ono, M., and Y. Takayama. 1992. Structures of cDNAs encoding chum salmon pituitary-specific transcription factor. Pit-1/GHF-1. Gene 116:275-279.
45. Pickett C. A., and A. Gutierrez-Hartmann. 1994. Ras mediates Src but not epidermal growth factor-receptor tyrosine kinase signaling pathways in GH4 neuroendocrine cells. Proc. Natl. Acad. Sci. USA 91:8612-8616.
46. Price, M., A. Rogers, and R. Treisman. 1995. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J. 14:2589-2601.
47. Schneikert, J., Y. Lutz, and B. Wasylyk. 1992. Two independent activation domains in cEts1 and cEts2 located in nonconserved sequences of the ets gene family. EMBO J. 7:249-256.
48. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
49. Theill, L. E., J. L. Castrillo, D. Wu, and M. Karin. 1989. Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature 342:945-948.
50. Theill, L. E., K. Hattori, D. Domenico, J.-L. Castrillo, and M. Karin. 1992. Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J. 11:2261-2269.
51. Voss, J. W., and M. G. Rosenfeld. 1992. Anterior pituitary development: short tales from dwarf mice. Cell 70:527-530.
52. Wasylyk, B., S. H. Hahn, and A. Giovane. 1993. The Ets family of transcription factors. Eur. J. Biochem. 211:7-18.
53. Wasylyk, B., C. Wasylyk, P. Flores, A. Begue, D. Leprince, and D. Stehelin. 1990. The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature 346:191-193.
54. Wasylyk, C., A. P. Bradford, A. Gutierrez-Hartmann, and B. Wasylyk. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene, in press.
55. Wasylyk, C., A. Gutman, R. Nicholson, and B. Wasylyk. 1991. The c-ets oncoprotem activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J. 10:1127-1134.
56. Wasylyk, C., J.-P. Kerckaert, and B. Wasylyk. 1992. A novel modulator domain of Ets transcription factors. Genes Dev. 6:965-974.
57. Wong, E. A., J. L. Silsby, and M. E. El Halawani. 1992. Complementary DNA cloning and expression of Pit-1/GHF-1 from the domestic turkey. DNA Cell Biol. 11:651-660.
58. Yang, B.-S., C. Hauser, G. Henkel, M. Colman, C. Van Beveren, K. Stacey, D. Hume, R. Maki, and M. Ostrowski. 1996. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activity of c-Ets-1 and c-Ets-2. Mol. Cell. Biol. 16:538-547.