A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins

Genes and Development

Volumn 11, Issue 11, 1997, Pages 1370-1380

  Bach, Ingolf ^a   Carrière, Catherine ^a   Ostendorff, Heather P ^c   Andersen, Bogi ^b   Rosenfeld, Michael G ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Coactivator; LIM and Otx homeodomain factors; LIM domain; Protein protein interaction; Synergistic transcriptional activation

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0030923755     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.11.1370     Document Type: Article

References (42)

1. Acampora, D., S. Mazan, Y. Lallemand, V. Avantaggiato, M. Maury, A. Simeone, and P. Brulet. 1995. Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121: 3279-3290.
2. Agulnick, A.D., M. Taira, J.J. Breen, T. Tanaka, I.B. Dawid, and H. Westphal. 1996. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature 384: 270-272.
3. Andersen, B., M.D. Schonemann, R.V. Pearse II, K. Jenne, J. Sugarman, and M.G. Rosenfeld. 1993. Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex. J. Biol. Chem. 268: 23390-23398.
4. Ang, S.L., O. Jin, M. Rhinn, N. Daigle, L. Stevenson, and J. Rossant. 1996. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122: 243-252.
5. Appel, B., V. Korzh, E. Glasgow, S. Thor, T. Edlund, I.B. Dawid, and J.S. Eisen. 1995. Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development 121: 4117-4125.
6. Bach, I, S.J. Rhodes, R.V. Pearse II, T. Heinzel, B. Gloss, K.M. Scully, P.E. Sawchenko, and M.G. Rosenfeld. 1995. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc. Natl. Acad. Sci. 92: 2720-2724.
7. Bernard, O., S. Ganiatsas, G. Kannourakis, and R. Dringen. 1994. Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 5: 1159-1171.
8. Dawid, I.B., R. Toyama, and M. Taira. 1995. LIM domain proteins. C.R. Acad. Sci. Ser. III 318: 295-306.
9. Ericson, J., S. Thor, T. Edlund, T.M. Jessell, and T. Yamada. 1992. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256: 155-160.
10. Feuerstein, R., X. Wang, D. Song, N.E. Cooke, and S.A. Liebhaber. 1994. The LIM/double zinc-finger motif functions as a protein dimerization domain. Proc. Natl. Acad. Sci. 91: 10655-10659.
11. German, M.S., J. Wang, R.B. Chadwick, and W.J. Rutter. 1992. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex. Genes & Dev. 6: 2165-2176.
12. Harlow, E. and D. Lane. 1988. Antibodies. A laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, pp. 421-446. Cold Spring Harbor, NY.
13. Ingraham, H.A., R.P. Chen, H.J. Mangalam, H.P. Elsholtz, S.E. Flynn, C.R. Lin, D.M. Simmons, L. Swanson, and M.G. Rosenfeld. 1988. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 50: 519-529.
14. Jurata, L.W., D.A. Kenny, and G.N. Gill. 1996. Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl. Acad. Sci. 93: 11693-11698.
15. Kaelin, W.G., W. Krek, W.R. Sellers, J.A. DeCaprio, F. Ajchenbaum, C.S. Fuchs, T. Chittenden, Y. Li, P.J. Farnham, M.A. Blanar, D.M. Livingston, and E.K. Flemington. 1992. Expression cloning of a retinoblastoma-binding protein with E2F-like properties. Cell 70: 351-364.
16. Karlsson, O., S. Thor, T. Norberg, H. Ohlsson, and T. Edlund. 1990. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo and a cys-his domain. Nature 344: 879-882.
17. Kendall, S.K., D.F. Gordon, T.S. Birkmeier, D. Petrev, V.D. Sarapura, S. O'Shea, W.M. Wood, R.V. Lloyd, E.G. Ridgway, and S.A. Camper. 1994. Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol. Endocrinol. 8: 1420-1433.
18. Lamoneirie, T., J.J. Tremblay, C. Lanctot, M. Therrien, Y. Gauthier, and J. Drouin. 1996. Ptx-1, a bicoid-related homeobox transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes & Dev. 10: 1284-1295.
19. Matsuo, I, S. Kuratani, C. Kimura, N. Takeda, and S. Aizawa. 1995. Mouse Otx2 functions in the formation and patterning of rostral head. Genes & Dev. 9: 2646-2658.
20. Mizuno, K., I. Okano, K. Ohashi, K. Nunoue, K. Kuma, T. Miyata, and T. Nakamura. 1994. Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. Oncogene 9: 1605-1612.
21. Pfaff, S.L., M. Mendelsohn, C.L. Stewart, T. Edlund, and T.M. Jessell. 1996. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependant step in interneuron differentiation. Cell 84: 309-320.
22. Rhodes, S.J., R. Chen, G.E. DiMattia, K.M. Scully, K.A. Kalla, S.C. Lin, V.C. Yu, and M.G. Rosenfeld. 1993. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the Pit-1 gene. Genes & Dev. 7: 913-932.
23. Roberson, M.S., W.E. Schoderbek, G. Tremml, and R.A. Maurer. 1994. Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factor. Mol. Cell. Biol. 14: 2985-2993.
24. Sánchez-García, I. and T.H. Rabbitt. 1994. The LIM domain: A new structural motif found in zinc-finger proteins. Trends Genet. 10: 315-320.
25. Sánchez-García, I., H. Osada, A. Forster, and T.H. Rabbitts. 1993. The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. EMBO J. 12: 4243-4250.
26. Schmeichel, K.L. and M.C. Beckerle. 1994. The LIM domain is a modular protein-binding interface. Cell 79: 211-219.
27. Seidah, N.G., J.-C. Barale, M. Marcinkiewicz, M.-G. Mattei, R. Day, and M. Chretien. 1994. The mouse homeoprotein mLIM-3 is expressed in cells derived from the neuroepithelium and persists in adult pituitary. DNA Cell Biol. 13: 1163-1180.
28. Semina, E.V., R. Reiter, L.J. Leysens, W.L.M. Alward, K.W. Small, N.A. Datson, J. Siegel-Bartelt, D. Bierke-Nelson, P. Bitoun, B.U. Zabel, J.C. Carey, and J.C. Murray. 1996. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nature Genet. 14: 392-399.
29. Shawlot, W. and R.R. Behringer. 1995. Requirement for Lim1 in head-organizer function. Nature 374: 425-430.
30. Sheng, H.Z., A.B. Zhadanov, B. Mosinger, T. Fujii, S. Bertuzzi, A. Grinberg, E.J. Lee, S.-P. Huang, K.A. Mahon, and H. Westphal. 1996. The LIM homeobox gene Lhx-3 is essential for the specification and proliferation of pituitary cell lineages. Science 256: 1555-1560.
31. Simeone, A., D. Acampora, M. Gulisano, A. Stornaiuolo, and E. Boncinelli. 1992. Nested expression domains of four homeobox genes in developing rostral brain. Nature 358: 687-690.
32. Simmons, D.M., J.W. Voss, H.A. Ingraham, J.M. Holloway, R.S. Broide, M.G. Rosenfeld, and L.W. Swanson. 1990. Pituitary cell phenotypes involve cell-specific Pit- 1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes & Dev. 4: 695-711.
33. Sornson, M.W., W. Wu, J.S. Dasen, S.E. Flynn, D.J. Norman, S.M. O'Connell, I. Gukovsky, C. Carrière, A.K. Ryan, A.P. Miller, L. Zuo, A.S. Gleiberman, B. Andersen, W.G. Beamer, and M.G. Rosenfeld. 1996. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384: 327-333.
34. Szeto, D.P., A.K. Ryan, S.M. O'Connell, and M.G. Rosenfeld. 1996. P-OTX: A Pit-1-interacting homeodomain factor expressed during anterior pituitary gland development. Proc. Natl. Acad. Sci. 93: 7706-7710.
35. Taira, M., M. Jamrich, P.J. Good, and I.B. Dawid. 1992. The LIM domain-containing homeobox gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes & Dev. 6: 356-366.
36. Taira, M., H. Otani, J.-P. Saint-Jeannet, and I.B. Dawid. 1994. Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus. Nature 372: 677-679.
37. Thor, S., J. Ericson, T. Brannstrom, and T. Edlund. 1991. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7: 881-889.
38. Tsuchida, T., M. Ensini, S.B. Morton, M. Baldassare, T. Edlund, T.M. Jessell, and S.L. Pfaff. 1994. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79: 957-970.
39. Wilkinson, D.G. 1993. In situ hybridization. In Essential developmental biology: A practical approach (ed. C.D. Stern and W.H. Holland), pp. 259-274. IRL, Oxford, UK.
40. Xu, Y., M. Baldassare, P. Fisher, G. Rathbun, E.M. Oltz, G.D. Yancopoulos, T.M. Jessell, and F. W. Alt. 1993. LH-2: A LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc. Natl. Acad. Sci. 90: 227-231.
41. Yamada, T., S.L. Pfaff, T. Edlund, and T.M. Jessell. 1993. Control of the cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate. Cell 73: 673-686.
42. Zhadanov, A., S. Bertuzzi, M. Taira, I.B. Dawid, and H. Westphal. 1995. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. Dev. Dynam. 202: 354-364.