Combinatorial synthesis of aminoglycoside libraries

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 4, 2001, Pages 462-470

  Sucheck, S J ^a   Shue, Y K ^a  

^a Optimer Pharmaceuticals Inc   (United States)

Author keywords

Aminoglycosides; Antibiotics; Carbohydrate libraries; Glycoconjugates; RNA recognition

Indexed keywords

2 DEOXYSTREPTAMINE; 2,6 DIAMINOGLUCOSE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; GLUCOSE DERIVATIVE; NEAMINE; PAROMOMYCIN; RNA; UNCLASSIFIED DRUG;

AMINATION; ANTIVIRAL ACTIVITY; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LIBRARY; REVIEW; RNA BINDING; STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CHEMISTRY, CLINICAL; CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS;

EID: 0034911509     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation
2. Functional interaction of neomycin B and related antibiotics with 30S and 50S ribosomal subunits
3. Interaction of antibiotics with functional sites in 16S ribosomal RNA
4. Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA
5. RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide
6. Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic
7. Targeting RNA with small molecules
8. Renaissance of interest in aminoglycoside antibiotics
9. RNA and the small molecule world
10. Synthesis of neamine libraries for RNA recognition using solution phase chemistry
11. Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive element
12. An access to glycoconjugate libraries through multicomponent reactions
13. Enhanced RNA binding of dimerized aminoglycosides
14. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes
15. Design, modeling and synthesis of functionalized paromamine analogs
16. De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing β-D-glucose as a novel scaffold
17. Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic
18. Carbohydrate-based small molecule scaffolds for the construction of universal pharmacophore mapping libraries
19. The generation of carbohydrate-based combinatorial libraries for drug discovery
20. Efficient synthesis of a stereochemically defined carbohydrate scaffold: Carboxymethyl 2-acetamido-6-azido-4-O-benzyl-2-deoxy-α-D-glucopyranoside
21. Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside-RNA interactions
22. A library approach to the discovery of small molecules that recognize RNA: Use of a 1,3-hydroxyamine motif as core
23. Molecular diversity and combinatorial chemistry: Library drug discovery conference
24. The search for structure-specific nucleic acid-interactive drugs: Effects of compound structure on RNA versus DNA interaction strength
25. Sequence dependence of 4′,6-diamidino-2-phenylindole (DAPI)-DNA
26. Strategies for the design of drugs targeting RNA and RNA-protein complexes
27. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production
28. Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA decoding region and the HIV-RRE activator region
29. Neomycin-acridine conjugate: A potent inhibitor of Rev-RRE binding
30. Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism
31. Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA
32. Inhibition of the hammerhead ribozyme by neomycin
33. Inhibition of hepatitis δ virus genomic ribozyme self-cleavage by aminoglycosides
34. Design of small molecules that recognize RNA: Development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences
35. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations
36. Controlling gene expression in living cells through small molecule-RNA interactions