Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive element

Journal of the American Chemical Society

Volumn 118, Issue 42, 1996, Pages 10150-10155

  Park, William K C ^a   Auer, Manfred ^b   Jaksche, Herbert ^b   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIVIRUS AGENT; NEAMINE;

ARTICLE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA BINDING;

EID: 0029905917     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9612817     Document Type: Article

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32. For the purpose of characterizations of the MCC products before deprotection, glycine methyl ester was used as the amine component instead of the PEG attached glycine.