메뉴 건너뛰기




Volumn 394, Issue 6688, 1998, Pages 88-92

A dimeric.14-3-3 protein is an essential cofactor for Raf kinase activity

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DIMER; EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 90; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPEPTIDE; PHOSPHOPROTEIN PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN; RAS PROTEIN; SYNTHETIC PEPTIDE;

EID: 0032474838     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/27938     Document Type: Article
Times cited : (404)

References (28)
  • 1
    • 0028175091 scopus 로고
    • Ras meets Raf: Completing the framework of a signal transduction pathway
    • Avruch, I., Zhang, X. F., Kyriakis, J. M. Ras meets Raf: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19, 279-283 (1994).
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 279-283
    • Avruch, I.1    Zhang, X.F.2    Kyriakis, J.M.3
  • 2
    • 0027433644 scopus 로고
    • Raf exists in a native heterocomplex with hsp90 and hsp50 that can be reconstituted in a cell-free system
    • Stancato, L. F. et al. Raf exists in a native heterocomplex with hsp90 and hsp50 that can be reconstituted in a cell-free system. J. Biol. Chem. 268, 21711-21716 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 21711-21716
    • Stancato, L.F.1
  • 3
    • 0028227245 scopus 로고
    • The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex
    • Wartmann, M. & Davis, R. J. The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex. J. Biol. Chem. 269, 6695-6701 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 6695-6701
    • Wartmann, M.1    Davis, R.J.2
  • 4
    • 0030248429 scopus 로고    scopus 로고
    • 14-3-3 and its possible role in co-ordinating multiple signalling pathways
    • Aitken, A. 14-3-3 and its possible role in co-ordinating multiple signalling pathways. Trends Cell Biol. 6, 341-347 (1996).
    • (1996) Trends Cell Biol. , vol.6 , pp. 341-347
    • Aitken, A.1
  • 6
    • 0027337248 scopus 로고
    • Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
    • Zhang, X.-F. et al. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364, 308-313 (1993).
    • (1993) Nature , vol.364 , pp. 308-313
    • Zhang, X.-F.1
  • 7
    • 0030919893 scopus 로고    scopus 로고
    • Activation of cRaf-1 by Ras and Src through different mechanisms: Activation in vivo and in vitro
    • Stokoe, D. & McCormick, F. Activation of cRaf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. EMBO J. 16, 2384-2396 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2384-2396
    • Stokoe, D.1    McCormick, F.2
  • 8
    • 0027242125 scopus 로고
    • Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase
    • Kyriakis, J. M., Force, T. L., Rapp, U. R., Bonventre, J. V. & Avruch, J. Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J. Biol. Chem. 268, 16009-16019 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 16009-16019
    • Kyriakis, J.M.1    Force, T.L.2    Rapp, U.R.3    Bonventre, J.V.4    Avruch, J.5
  • 9
    • 0027168907 scopus 로고
    • Identification of the major phosphorylation sites of the Raf-1 kinase
    • Morrison, D. K., Heidecker, G., Rapp, U. R. & Copeland, T. D. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268, 17309-17316 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 17309-17316
    • Morrison, D.K.1    Heidecker, G.2    Rapp, U.R.3    Copeland, T.D.4
  • 10
    • 0029014973 scopus 로고
    • Reversal of Raf-1 activaiton by purified and membrane-associated protein phosphatases
    • Dent, P., Jelinek, T., Morrison, D. K., Weber, M. J. & Sturgill, T. W. Reversal of Raf-1 activaiton by purified and membrane-associated protein phosphatases. Science 268, 1902-1906 (1995).
    • (1995) Science , vol.268 , pp. 1902-1906
    • Dent, P.1    Jelinek, T.2    Morrison, D.K.3    Weber, M.J.4    Sturgill, T.W.5
  • 12
    • 0030999664 scopus 로고    scopus 로고
    • 14-3-3ε positively regulates Ras-mediated signalling in Drosophila
    • Chang, H. C. & Rubin, G. M. 14-3-3ε positively regulates Ras-mediated signalling in Drosophila. Genes Dev. 11, 1132-1139 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1132-1139
    • Chang, H.C.1    Rubin, G.M.2
  • 13
    • 0030953744 scopus 로고    scopus 로고
    • Requirement for Drosophila 14-3-3ζ in Raf-dependent photoreceptor development
    • Knockel, L., Vorbruggen, G., Jacklem, H., Mlodzik, M. & Bohmann, D. Requirement for Drosophila 14-3-3ζ in Raf-dependent photoreceptor development. Genes Dev. 11, 1140-1147 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1140-1147
    • Knockel, L.1    Vorbruggen, G.2    Jacklem, H.3    Mlodzik, M.4    Bohmann, D.5
  • 14
    • 0028073606 scopus 로고
    • Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
    • Freed, E., Symons, M., Macdonald, S. G., McCormick, F. & Ruggieri, R. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265, 1713-1716 (1994).
    • (1994) Science , vol.265 , pp. 1713-1716
    • Freed, E.1    Symons, M.2    Macdonald, S.G.3    McCormick, F.4    Ruggieri, R.5
  • 15
    • 0028051904 scopus 로고
    • Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase
    • Irie, K. et al. Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science 265, 1716-1719 (1994).
    • (1994) Science , vol.265 , pp. 1716-1719
    • Irie, K.1
  • 16
    • 0027944852 scopus 로고
    • Activation of Raf by 14-3-3 proteins
    • Fantl, W. J. et al. Activation of Raf by 14-3-3 proteins. Nature 371, 612-614 (1994).
    • (1994) Nature , vol.371 , pp. 612-614
    • Fantl, W.J.1
  • 17
    • 0029871708 scopus 로고    scopus 로고
    • Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
    • Muslin, A. J., Tanner, J. W., Allen, P. M. & Shaw, A. S. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84, 889-898 (1996).
    • (1996) Cell , vol.84 , pp. 889-898
    • Muslin, A.J.1    Tanner, J.W.2    Allen, P.M.3    Shaw, A.S.4
  • 18
    • 0028842660 scopus 로고
    • Identification of the 14-3-3ζ domains important for self-association and Raf binding
    • Luo, Z.-J., Zhang, X.-F., Rapp, U. & Avruch, J. Identification of the 14-3-3ζ domains important for self-association and Raf binding. J. Biol. Chem. 270, 23681-23687 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 23681-23687
    • Luo, Z.-J.1    Zhang, X.-F.2    Rapp, U.3    Avruch, J.4
  • 19
    • 0029071689 scopus 로고
    • 14-3-3 is not essential for Raf-1 function: Identification of cRaf-1 proteins that are biologically activated in a 14-3-3 and Ras-independent manner
    • Michaud, N. R., Fabian, J. R., Mathes, K. D. & Morrison, D. K. 14-3-3 is not essential for Raf-1 function: identification of cRaf-1 proteins that are biologically activated in a 14-3-3 and Ras-independent manner. Mol. Cell Biol. 15, 3390-3397 (1995).
    • (1995) Mol. Cell Biol. , vol.15 , pp. 3390-3397
    • Michaud, N.R.1    Fabian, J.R.2    Mathes, K.D.3    Morrison, D.K.4
  • 20
    • 0028115999 scopus 로고
    • Interaction of the protein kinase Raf-1 with 14-3-3 proteins
    • Fu, H. et al. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science 266, 126-129 (1994).
    • (1994) Science , vol.266 , pp. 126-129
    • Fu, H.1
  • 21
    • 0029113212 scopus 로고
    • Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells
    • Suen, K.-L., Bustelo, X. R. & Barbacid, M. Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene 11, 825-831 (1995).
    • (1995) Oncogene , vol.11 , pp. 825-831
    • Suen, K.-L.1    Bustelo, X.R.2    Barbacid, M.3
  • 22
    • 0030831968 scopus 로고    scopus 로고
    • 14-3-3ζ negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain
    • Clark, G. J. et al. 14-3-3ζ negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain. J. Biol. Chem. 272, 20990-20993 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 20990-20993
    • Clark, G.J.1
  • 23
    • 0030853961 scopus 로고    scopus 로고
    • Negative regulation of Raf activity by binding 14-3-3 to the aminoterminus of Raf in vivo
    • Rommel, C., Radziwill, G., Moelling, K. & Hafen, E. Negative regulation of Raf activity by binding 14-3-3 to the aminoterminus of Raf in vivo. Mech. Dev. 4, 95-104 (1997).
    • (1997) Mech. Dev. , vol.4 , pp. 95-104
    • Rommel, C.1    Radziwill, G.2    Moelling, K.3    Hafen, E.4
  • 24
    • 0029811985 scopus 로고    scopus 로고
    • Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
    • Luo, Z.-J., Tzivion, G., Belshaw, P. J., Marshall, M. & Avruch, J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 383, 181-185 (1996).
    • (1996) Nature , vol.383 , pp. 181-185
    • Luo, Z.-J.1    Tzivion, G.2    Belshaw, P.J.3    Marshall, M.4    Avruch, J.5
  • 25
    • 0029807304 scopus 로고    scopus 로고
    • Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
    • Farrar, M. A., Alberol-Ila & Perimutter, R. M. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 383, 178-181 (1996).
    • (1996) Nature , vol.383 , pp. 178-181
    • Farrar, M.A.1    Alberol-Ila2    Perimutter, R.M.3
  • 26
    • 0029046812 scopus 로고
    • Crystal structure of the zeta isoform of the 14-3-3 protein
    • Liu, D. et al. Crystal structure of the zeta isoform of the 14-3-3 protein. Nature 376, 191-194 (1995).
    • (1995) Nature , vol.376 , pp. 191-194
    • Liu, D.1
  • 27
    • 0030064432 scopus 로고    scopus 로고
    • Activated Ras displaces 14-3-3 protein from the aminoterminus of cRaf-1
    • Rommel, C. et al. Activated Ras displaces 14-3-3 protein from the aminoterminus of cRaf-1. Oncogene 12, 609-619 (1996).
    • (1996) Oncogene , vol.12 , pp. 609-619
    • Rommel, C.1
  • 28
    • 0027251721 scopus 로고
    • The Retinoblastoma protein associates with protein phosphatase type 1 catalytic subunit
    • Durfee, T. et al. The Retinoblastoma protein associates with protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 555-569
    • Durfee, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.