Role of c-Jun N-terminal kinase/p38 stress signaling in 1-β-D-arabinofuranosylcytosine-induced apoptosis

Biochemical Pharmacology

Volumn 59, Issue 4, 2000, Pages 407-418

  Stadheim, Terrance A ^a   Saluta, Gilda R ^a   Kucera, Gregory L ^a  

^a WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

1 D arabinofuranosylcytosine; Apoptosis; ERK; JNK; p38; PD098059; SAPK; SB203580

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CYTARABINE; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRAIN HL 60; CLONOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING;

APOPTOSIS; CYTARABINE; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0033975862     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00330-5     Document Type: Article

References (39)

1. Mastrianni D.M., Tung N.M., Tenen D.G. Acute myelogenous leukemia Current treatment and future directions . Am J Med. 92:1992;286-295.
2. Fram R.J., Kufe D.W. DNA strand breaks caused by inhibitors of DNA synthesis 1-β-D-arabinofuranosylcytosine and aphidicolin . Cancer Res. 42:1982;4050-4053.
3. Ohno Y., Spriggs D., Matsukage A., Ohno T., Kufe D. Effects of 1-β-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase β Cancer Res. 48:1988;1494-1498.
4. Strum J.C., Small G.W., Pauig S.B., Daniel L.W. 1-β-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J Biol Chem. 269:1994;15493-15497.
5. Kucera G.L., Capizzi R.L. 1-β-D-Arabinofuranosylcytosine-diphosphate-choline is formed by the reversal of cholinephosphotransferase and not via cytidylyltransferase. Cancer Res. 52:1992;3886-3891.
6. Peña L.A., Fuks Z., Kolesnick R. Stress-induced apoptosis and the sphingomyelin pathway. Biochem Pharmacol. 53:1997;615-621.
7. Grant S., Freemerman A.J., Birrer M.J., Martin H.A., Turner A.J., Szabo E., Chelliah J., Jarvis W.D. Effect of 1-β-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67). Cell Growth Differ. 7:1996;603-613.
8. Marshall C.J. Specificity of receptor tyrosine kinase signaling Transient versus sustained extracellular signal-regulated kinase activation . Cell. 80:1995;179-185.
9. Zanke B.W., Boudreau K., Rubie E., Winnett E., Tibbles L.A., Zon L., Kyriakis J., Liu F.F., Woodgett J.R. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 6:1996;606-613.
10. Enslen H., Raingeaud J., Davis R.J. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 273:1998;1741-1748.
11. Guan Z., Buckman S.Y., Pentland A.P., Templeton D.J., Morrison A.R. Induction of cyclooxygenase-2 by the activated MEKK1 → SEK1/MKK4 → p38 mitogen-activated protein kinase pathway. J Biol Chem. 273:1998;12901-12908.
12. Frasch S.C., Nick J.A., Fadok V.A., Bratton D.L., Worthen G.S., Henson P.M. p38 Mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 273:1998;8389-8397.
13. Ichijo H., Nishida E., Irie K., Tendijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 275:1997;90-94.
14. Kawasaki H., Morooka T., Shimohama S., Kimura J., Hirano T., Gotoh Y., Nishida E. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem. 272:1997;18518-18521.
15. Kummer J.L., Rao P.K., Heidenreich K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 272:1997;20490-20494.
16. Nemoto S., Xiang J., Huang S., Lin A. Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase. J Biol Chem. 273:1998;16415-16420.
17. Nemoto S., Sheng Z., Lin A. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol. 18:1998;3518-3526.
18. Roulston A., Reinhard C., Amiri P., Williams L.T. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α J Biol Chem. 273:1998;10232-10239.
19. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
20. Zechner D., Craig R., Hanford D.S., McDonough P.M., Sabbadini R.A., Glembotski C.C. MKK6 activates myocardial cell NF-κB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J Biol Chem. 273:1998;8232-8239.
21. Saleem A., Datta R., Yuan Z.M., Kharbanda S., Kufe D. Involvement of stress-activated protein kinase in the cellular response to 1-β-D-arabinofuranosylcytosine and other DNA-damaging agents. Cell Growth Differ. 6:1995;1651-1658.
22. Pandey P., Raingeaud J., Kaneki M., Weichselbaum R., Davis R.J., Kufe D., Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. J Biol Chem. 271:1996;23775-23779.
23. L inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res. 56:1996;4743-4748.
24. Stadheim T.A., Kucera G.L. Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis. Biochem Biophys Res Commun. 245:1998;266-271.
25. Ray S., Ponnathpur V., Huang Y., Tang C., Mahoney M.E., Ibrado A.M., Bullock G., Bhalla K. 1-β-D-Arabinofuranosylcytosine-, mitoxantrone-, and paclitaxel-induced apoptosis in HL-60 cells Improved method for detection of internucleosomal DNA fragmentation . Cancer Chemother Pharmacol. 34:1994;365-371.
26. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
27. Capizzi R.L., Yang J.-L., Cheng E., Bjornsson T., Sahasrabudhe D., Tan R.-S., Cheng Y.-C. Alteration of the pharmacokinetics of high dose ara-C by its metabolite, high ara-U in patients with acute leukemia. J Clin Oncol. 1:1983;763-771.
28. Chen Y.-R., Wang X., Templeton D., Davis R.J., Tan T.-H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem. 271:1996;31929-31936.
29. Yu R., Shtil A.A., Tan T.H., Roninson I.B., Kong A.N.T. Adriamycin activates c-Jun N-terminal kinase in human leukemia cells A relevance to apoptosis . Cancer Lett. 107:1996;73-81.
30. Young P.R., McLaughlin M.M., Kumar S., Kassis S., Doyle M.L., McNulty D., Gallagher T.F., Fisher S., McDonnell P.C., Carr S.A., Huddleston M.J., Seibel G., Porter T.G., Livi G.P., Adams J.L., Lee J.C. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem. 272:1997;12116-12121.
31. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
32. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50.
33. Gunji H., Kharbanda S., Kufe D. Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-β-D-arabinofuranosylcytosine. Cancer Res. 51:1991;741-743.
34. Datta R., Banach D., Kojima H., Talanian R.V., Alnemri E.S., Wong W.W., Kufe D.W. Activation of the CPP32 protease in apoptosis induced by 1-β-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood. 88:1996;1936-1943.
35. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res. 57:1997;3115-3120.
36. Jarvis W.D., Fornari F.A. Jr, Tombes R.M., Erukulla R.K., Bittman R., Schwartz G.K., Dent P., Grant S. Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-β-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol Pharmacol. 54:1998;844-856.
37. Mohr S., McCormick T.S., Lapetina E.G. Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors Dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059 . Proc Natl Acad Sci USA. 95:1998;5045-5050.
38. Schultz H., Engel K., Gaestel M. PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype. J Cell Physiol. 173:1997;310-318.
39. Berra E., Diaz-Meco M.T., Moscat J. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem. 273:1998;10792-10797.