The mitogen-activated protein kinase kinase/extracellular signal- regulated kinase cascade activation is a key signalling pathway involved in the regulation of G1 phase progression in proliferating hepatocytes

Molecular and Cellular Biology

Volumn 19, Issue 9, 1999, Pages 6003-6011

  Talarmin, Hélène ^a   Rescan, Claude ^a   Cariou, Sandrine ^a   Glaise, Denise ^a   Zanninelli, Giuliana ^a   Bilodeau, Marc ^a   Loyer, Pascal ^a   Guguen Guillouzo, Christiane ^a   Baffet, Georges ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN D1; DNA; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PYRUVIC ACID; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL FUNCTION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVATION; FEMALE; LIVER REGENERATION; LIVER RESECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032795940     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.6003     Document Type: Article

References (63)

1. Adachi, T., S. Nakashima, S. Saji, T. Nakamura, and Y. Nozawa. 1997. Possible involvement of pertussis toxin-sensitive G protein in nepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: pertussis toxin treatment inhibits activation of phospholipid signalling, calcium oscillation, and mitogen-activated protein kinase. Hepatology 26:295-300.
2. Albanese, C., J. Johnson, G. Watanabe, N. Eklund, D. Vu. A. Arnold, and R. G. Pestell. 1995. Transforming p21 ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270: 23589-23597.
3. Albrecht, J. H., M. Y. Hu, and F. B. Cerra. 1995. Distinct patterns of cyclin D1 regulation in models of liver regeneration and human liver. Biochem. Biophys. Res. Commun. 209:548-655.
4. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 98059 is a specific inhibitor of activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489-27494.
5. Auer, K. L., J. Contessa, S. Brenz-Verca, L. Pirola, S. Rusconi, G. Cooper, A. Abo, M. P. Wymann, R. J. Davis, M. Birrer, and P. Dent. 1998. The Ras/ Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of hepatocytes. Mol. Biol. Cell 9:561-573.
6. Block, G. D., J. Locker, W. C. Bowen, B. E. Petersen, S. Katyal, S. C. Storm, T. Riley, T. A. Howard, and G. K. Michalopoulos. 1996. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGFa in a chemically defined (HGM) medium. J. Cell Biol. 132:1133-1149.
7. Boylan, J. M., and P. A. Gruppuso. 1994. In vitro and in vivo regulation of hepatic mitogen-activated protein kinases in foetal rats. Am. J. Physiol. 267:G1078-G1086.
8. Chen, J., E. J. N. Ishac, P. Dent, G. Kunos, and B. Gao. 1998. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem. J. 334:669-676.
9. Cheng, M., V. Sexl, C. J. Sherr, and M. F. Roussel. 1998. Assembly of cyclin-dependent kinase and titration of p27kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl. Acad. Sci. USA 95:1091-1096.
10. dark-Lewis, I., J. S. Sanghera, and S. L. Pelech. 1991. Definition of a consensus sequence for peptide substrate recognition by p44 mpk, the meiosis-activated myelin basic protein kinase. J. Biol. Chem. 266:15180-15184.
11. 2+-dependent signal pathways in rat-1-cells. J. Biol. Chem. 272:13309-13319.
12. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase is necessary and sufficient for PC 12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
13. Cressman, D. E., L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, V. Poli, and R. Taub. 1996. Liver failure and defective hepatocyte regeneration in interleukine-6-deficient mice. Science 274:1379-1383.
14. Diehl, A. M., and R. M. Rai. 1996. Regulation of signal transduction during liver regeneration. FASEB J. 10:215-227.
15. Etienne, P. L., G. Baffet, B. Desvergne, M. Boisnard-Rissel, D. Glaise, and C. Guguen-Guillouzo. 1988. Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes. Oncogene Res. 3:255-262.
16. Fabrikant, J. I. 1968. The kinetic of cellular proliferation in regenerating liver. J. Cell Biol, 36:551-565.
17. Fausto, N., A. D. Laird, and E. M. Webber. 1995. Role of growth factors and cytokines in hepatic regeneration. FASEB J. 9:1527-1536.
18. Fiddes, R. J., P. W. Janes, S. P. Sivertsen, R. L. Sutherland, E. A. Musgrove, and R. J. Daly. 1998. Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells. Oncogene 16:2803-2813.
19. Gines, P., X. Li, S. E. S. Brown, T. Nakamura, P. S. Guzelian, L. E. Heasley, R. W. Schirer, and R. A. Nemenoff. 1996. Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes. Hepatology 23:1167-1173.
20. Gomez-Lechon, M. J., I. Guillen, X. Ponsoda, R. Fabra, R. Trullenque, T. Nakamura, and J. V. Castell. 1996. Cell cycle progression proteins (cyclins), oncogene expression, and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor. Hepatology 23: 1012-1019.
21. Goyette, M., C. J. Petropoulos, P. R. Shank, and N. Fausto. 1983. Expression of a cellular oncogene during cellular regeneration. Science 219:510-512.
22. Greulich, H., and R. L. Erikson. 1998. An analysis of MEK1 signaling in cell proliferation and transformation. J. Biol. Chem. 273:13280-13288.
23. 3. Cancer Res. 22:842-849.
24. Guguen, C., A. Guillouzo, M. Boisnard, A. Le Cam, and M. Bourel. 1975. Etude ultrastructurale de monocouches d'hépatocytes de rat cultivés en présence d'hémisuccinate d'hydrocortisone. Biol. Gastroenterol. 8:223-231.
25. Higgins, G. M., and R. M. Anderson. 1931. Experimental pathology of liver; restoration of the liver of the white rat following partial surgical removal. Arch. Pathol. 12:186-202.
26. Ikeda, T., N. Sawada, K. Fujinga, T. Minase, and M. Mori. 1989. c-Ha-ras gene is expressed at the G1 phase in primary cultures of hepatocytes. Exp. Cell Res. 185:292-296.
27. Ito, Y., Y. Sasaki, M. Horimoto, S. Wada, Y. Tanaka, A. Kasahara, T. Ueki, T. Hirano, H. Yamamoto, J. Fujimoto, E. Okamoto, N. Hasashi, and M. Hori. 1998. Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 27: 951-958.
28. Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. 1993. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 12:5097-5104.
29. Jarvis, W. D., K. L. Auer, M. Spector, G. Kunos, S. Grant, P. Hylemon, R. Mikkelsen, and P. Dent. 1997. Positive and negative regulation of JNK1 by protein kinase C and p42 MAP kinase in adult rat hepatocytes. FEBS Lett. 412:9-14.
30. Kahan, C., K. Seuwen, S. Meloche, and J. Pouysségur. 1992. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. J. Biol. Chem. 267:13369-13375.
31. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483-16486.
32. Kitano, S., T. W. Fawcett, Y. Yo, and G. S. Roth. 1998. Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats. Am. J. Physiol. 275:C146-C154.
33. Koch, K. S., X. P. Lu, and H. L. Leffert. 1994. Primary rat hepatocytes express cyclin D1 messenger RNA during their growth cycle and during mitogenic transitions induced by transforming growth factor-alpha. Biochem. Biophys. Res. Commun. 204:91-97.
34. Kruijer, W., H. Skelly, F. Botteri, H. Van der Putten, J. R. Barber, I. M. Verma, and H. L. Leffert. 1986. Proto-oncogene expression in regenerating liver is stimulated in culture of primary adult rat hepatocytes. J. Biol. Chem. 261:7929-7933.
35. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
36. Lavoie, J. N., G. L'Allemain, A. Brunnet, R. Müller, and J. Pouysségur. 1996. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOG MAPK pathway. J. Biol. Chem. 271:20608-20616.
37. Lavoie, J. N., N. Rivard, G. L'Allemain, and J. Pouysségur. 1996. A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry. Prog. Cell Cycle Res. 2:49-58.
38. Liu, Y., K. Z. Guyton, M. Gorospe, Q. Xu, G. C. Kokkonen, Y. D. Mock, G. S. Roth, and N. J. Holbrook. 1996. Age-related decline in mitogen-activated protein kinase in epidermal growth factor-stimulated rat hepatocytes. J. Biol. Chem. 271:3604-3607.
39. Loyer, P., S. Cariou, D. Glaise, M. Bilodeau, G. Baffet, and C. Guguen-Guillouzo. 1996. Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro. J. Biol. Chem. 271:11484-11492.
40. Loyer, P., D. Glaise, S. Cariou, G. Baffet, L. Meijer, and C. Guguen-Guillouzo. 1994. Expression and activation of Cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J. Biol. Chem. 269:2491-2500.
41. Lu, X. P., K. S. Koch, D. J. Lew, V. Dulic, J. Pines, S. I. Reed, T. Hunter, and H. L. Leffert. 1992. Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration. J. Biol. Chem. 267:2841-2844.
42. Marshall, M. S. 1995. Ras target proteins in eukaryotic cells. FASEB J. 9:1311-1318.
43. McKillop, I. H., C. M. Schmidt, P. A. Cahill, and J. V. Sitzmann. 1997. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology 26:1484-1491.
44. Michalopoulos, G. K., and M. C. DeFrances. 1997. Liver regeneration. Science 276:60-66.
45. Morello, D., A. Lavenu, and C. Babinet, 1990. Differential regulation and expression of c-jun, c-fos and c-myc protooncogenes during mouse liver regeneration and after inhibition of protein synthesis. Oncogene 5:1511-1519.
46. Musgrove, E. A., J. A. Hamilton, C. S. L. Lee, K. J. E. Sweeney, C. K. W. Watts, and R. L. Sutherland. 1993. Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol. Cell. Biol. 13:3577-3587.
47. Pagès, G., P. Lenormand, G. L'Allemain, J.-C. Chambard, S. Meloche, and J. Pouysségur. 1993. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90:8319-8323.
48. Pang, L., T. Sawada, S. T. Decker, and A. R. Saltiel. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270:13585-13588.
49. Robinson, M. J., and M. H. Cobb. 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9:180-186.
50. Sasse, J., U. Hemmann, C. Schwartz, U. Schniertshauer, B. Heesel, C. Landgraf J. Schneider-Mergener, P. C. Heinrich, and F. Horn. 1997. Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol. Cell. Biol. 17:4677-4686.
51. Schaper, F., E. Siewert, M. J. Gomez-Lechon, P. Gatsios, M. Sachs, W. Birchmeier, P. C. Heinrich, and J. Castell. 1997. Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes. FEBS Lett. 405:99-103.
52. Schmidt, C. M., I. H. McKillop, P. A. Cahill, and J. V. Sitzmann. 1997. Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 236:54-58.
53. Seger, R., D. Seger, A. A. Reszka, E. S. Munar, H. Eldar-Finkelman, G. Dobrowolska, A. M. Jensen, J. S. Campbell, E. F. Fisher, and E. G. Krebs. 1994. Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J. Biol. Chem. 269:25699-25709.
54. Sobczak, J., N. Mechti, M. F. Tournier, J. M. Blanchard, and M. Duguet. 1989. c-myc and c-fos genes in regulation during mouse liver regeneration. Oncogene 4:1503-1508.
55. Spector, M. S., K. L. Auer, W. D. Jarvis, E. J. N. Ishac, B. Gao, G. Kunos, and P. Dent. 1997. Differential regulation of mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Mol. Cell. Biol. 17:3556-3565.
56. Stolz, D. B., and G. K. Michalopoulos. 1994. Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes. J. Cell Biol. 55:445-464.
57. Taub, R. 1996. Transcriptional control of liver regeneration. FASEB J. 10:413-427.
58. Taub, R. 1998. Blocking NF-kappaB in the liver: the good and bad news. Hepatology 27:1445-1446.
59. Tombes, R. M., K. L. Auer, R. Mikkelsen, K. Valerie, M. P. Wymann, C. J. Marshall, M. McMahon, and P. Dent. 1998. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330:1451-1460.
60. Weber, J. D., D. M. Raben, P. J. Phillips, and J. J. Baldassare. 1997. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem. J. 326:61-68.
61. Westwick, J. K., J. Fleckenstein, M. Yin, S. Q. Yang, C. A. Bradham, D. A. Brenner, and A. M. Diehl. 1996. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro and in vivo. Am. J. Physiol. 271:G780-G790.
62. Yamada, Y., I. Kirillowa, J. J. Peschon, and N. Fausto. 1997. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA 94:1441-1446.
63. Yan, M., and D. J. Templeton. 1994. Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase. J. Biol. Chem. 269:19067-19073.