Ligands for natural killer cell receptors: Redundancy or specificity

Immunological Reviews

Volumn 181, Issue , 2001, Pages 158-169

  Cerwenka, Adelheid ^a   Lanier, Lewis L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; RETINOIC ACID; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; CELL ACTIVATION; DNA POLYMORPHISM; GENE EXPRESSION; GENETIC CODE; HISTOCOMPATIBILITY; HUMAN; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROBIAL IMMUNITY; MULTIGENE FAMILY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR INTRINSIC ACTIVITY; REVIEW; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD94; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 0034904144     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1810113.x     Document Type: Review

References (90)

1. Severe herpesvirus infections in an adolescent without natural killer cells
2. HLA class I recognition by killer cell Ig-like receptors
3. Regulation of immune responses through inhibitory receptors
4. Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors
5. NK cell recognition of non-classical HLA class 1 molecules
6. Activation of natural killer cells and T cells by NKG2D, a receptor for stress-inducible MICA
7. MIC genes: From genetics to biology
8. Soluble forms of the novel MHC class I-related molecules, ULBP1 and ULBP2, bind to and functionally activate NK cells
9. The human cytomegalovirus (HCMV) glycoprotein, UL16, binds to the MHC class I-related protein, MICB/PERB11, and to two novel, MHC class I-related molecules, ULBP1 and ULBP2
10. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
11. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages
12. NK cell receptors: Of missing sugar and missing self
13. NK cell activation: Distinct stimulatory pathways counterbalancing inhibitory signals
14. Face off - The interplay between activating and inhibitory receptors
15. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
16. Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12
17. Turning on natural killer cells
18. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
19. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors
20. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand
21. The Ly-49D receptor activates murine natural killer cells
22. Ly49D and Ly49H associate with mouse DAP12 and form activating receptors
23. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
24. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
25. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice
26. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
27. The natural killer gene complex genetic locus Chok encodes Ly-49D, it target recognition receptor that activates natural killing
28. Genetic control of natural killing and in vivo tumor elimination by the Chok locus
29. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor
30. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
31. Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors
32. Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice
33. Functions of nonclassical MHC and non-MHC-encoded class I molecules
34. Follow the leader: NK cell receptors for classical and non-classical MHC class I
35. Natural killer cells fertile with receptors for HLA-G?
36. Structural features impose tight peptide binding specificity in the non-classical MHC molecule HLA-E
37. HLA-E binds to natural killer cell receptors CD94/NKG2A, B, and C
38. Association of DAP12 with activating CD94/NKG2C NK cell receptors
39. Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E
40. Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors
41. Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays
42. Surface expression of HLA-E-, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40
43. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells
44. b
45. b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
46. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
47. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
48. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48
49. Identification of the 2B4 molecule as a counter-receptor for CD48
50. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
51. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
52. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation
53. + T cell activation
54. Development and function of T cells in mice with a disrupted CD2 gene
55. Expression of the BLAST-1 activation/adhesion molecule and its identification as CD48
56. Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-κB site
57. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
58. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
59. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
60. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
61. The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering
62. Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
63. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
64. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
65. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC
66. Genes in a 220-kb region spanning the TNF cluster in human MHC
67. Identification and molecular characterization of NKP30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
68. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
69. An activating receptor complex on natural killer and T cells formed by NKG2D and DAP10
70. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells
71. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
72. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway
73. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells
74. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not Th2 cytokines
75. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells
76. Self-recognition of CD1 by γδ cells, implications for innate immunity
77. A second lineage of mammalian major histocompatibility complex class I genes
78. Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Behçet disease
79. MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype
80. A single amino acid substitution causes loss of expression of a MICA allele
81. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
82. Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand
83. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
84. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain
85. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: One of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein
86. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: A novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules
87. The molecular and functional characterization of a dominant minor H antigen, H60
88. Differences that matter: Major cytotoxic T cell-stimulating minor histocompatibility antigens
89. On guard - Activating NK cell receptors
90. Cytomegalovirus evasion of natural killer cell responses