Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand

Nature

Volumn 402, Issue 6762, 1999, Pages 623-631

  Tormo, José ^a,b   Natarajan, Kannan ^c   Margulles, David H ^c   Mariuzza, Roy A ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN SUBUNIT; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GLYCOSYLATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TARGET CELL;

ANTIGENS, LY; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; H-2 ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0033540084     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45170     Document Type: Article

References (50)

1. Lanier, L. L. NK cell receptors. Annu. Rev. Immunol. 16, 359-393 (1998).
2. Yokoyama, W. M. in Fundamental Immunology (ed. Paul, W. E.) 575-603 (Lippincott-Raven, Philadelphia, 1999).
3. Long, E. O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17, 875-904 (1999).
4. Kärre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature 319, 675-678 (1986).
5. Ljunggren, H. G. & Kärre, K. In search of the "missing self": MHC molecules and NK cell recognition. Immunol. Today 11, 237-244 (1990).
6. Fan, Q. R. et al. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Nature 389, 96-100 (1997).
7. Snyder, G. A., Brooks, A. G. & Sun, P. D. Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proc. Natl Acad. Sci. USA 96, 3864-3869 (1999).
8. Maenaka, K., Juji, T., Stuart, D. I. & Jones, E. Y. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I. Structure 7, 391-398 (1999).
9. Boyington, J. C. et al. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. Immunity 10, 75-82 (1999).
10. Garcia, K. C., Teyton, L. & Wilson, I. A. Structural basis of T cell recognition. Annu. Rev. Immunol. 17, 369-397 (1999).
11. d: identification of a site distinct from the TCR site. Immunity 11, 591-601 (1999).
12. d complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120. J. Mol. Biol. 283, 179-191 (1998).
13. Weis, W. I., Taylor, M. E. & Drickamer, K. The C-type lectin superfamily in the immune system. Immunol. Rev. 163, 19-34 (1998).
14. Weis, W. I., Kahn, R., Fourme, R., Drickamer, K. & Hendrickson, W. A. Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing. Science 254, 1608-1615 (1991).
15. Poget, S. F. et al. The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D-galactose. J. Mol. Biol. 290, 867-879 (1999).
16. 2+-dependent structural changes in C-type mannose-binding proteins. Biochemistry 37, 17965-17976 (1998).
17. Weis, W. I. & Drickamer, K. Trimeric structure of a C-type mannose-binding protein. Structure 2, 1227-1240 (1994).
18. Sheriff, S., Chan, C. Y. & Ezekowitz, R. A. B. Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple α-helical coiled-coil Nature Struct. Biol. 1, 789-794 (1994).
19. Graves, B. J. et al. Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature 367, 532-538 (1994).
20. Lo Conte, L., Chothia, C. & Janin, J. The atomic structure of protein-protein recognition sites. J. Mol. Biol. 285, 2177-2198 (1999).
21. Wang, J.-H. et al. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell 97, 791-803 (1999).
22. Lawrence, M. C. & Colman, P. M. Shape complementarity at protein/protein interfaces. J. Mol. Biol. 234, 946-950 (1993).
23. + IL-2 activated natural killer cells. Nature 358, 66-70 (1992).
24. Gao, G. F. et al. Crystal structure of the complex between human CD8αα and HLA-A2. Nature 387, 630-634 (1997).
25. b. Immunity 9, 519-530 (1998).
26. d MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 Å resolution: implications for T cell and NK cell recognition. Immunity 9, 199-208 (1998).
27. Correa, I. & Raulet, D. H. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity 2, 61-71 (1995).
28. Orihuela, M., Margulies, D. H. & Yokoyam, W. M. The natural killer cell receptor Ly49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc. Natl Acad. Sci. USA 93, 11792-11797 (1996).
29. Matsumoto, N., Ribaudo, R. K., Abastado, J. P., Margulies, D. H. & Yokoyama, W. M. The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand. Immunity 8, 245-254 (1998).
30. d restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J. Immunol. 160, 5971-5978 (1998).
31. + IL-2 activated natural killer cells. Nature 358, 66-70 (1992).
32. Brennan, J., Mahon, G., Mager, D. L., Jefferies, W. A. & Takei, F. Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. J. Exp. Med. 183, 1553-1559 (1996).
33. d, has a functional carbohydrate recognition domain. Immunity 1, 785-792 (1994).
34. Brennan, J., Takei, F., Wong, S. & Mager, D. L. Carbohydrate recognition by a natural killer cell receptor, Ly-49C. J. Biol. Chem. 270, 9691-9694 (1995).
35. d on N-linked carbohydrate(s): possible involvement in Ly-49A interaction. J. Immunol. 160, 4367-4374 (1998).
36. Lian, R. H., Freeman, J., D., Mager, D. L. & Takei, F. Role of conserved glycosylation site unique to murine class I MHC in recognition by Ly-49 NK cell receptor. J. Immunol. 161, 2031-2036 (1998).
37. Hanke, T. et al. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11, 67-77 (1999).
38. Madden, D. R. The three-dimensional structure of peptide-MHC complexes. Annu. Rev. Immunol. 13, 387-622 (1995).
39. Kåse, A., Johansson, M. H., Olsson-Alheim, M. Y., Kärre, K. & Höglund, P. External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells. J. Immunol. 161, 6133-6138 (1998).
40. Andersson, M. et al. MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells. J. Immunol. 161, 6475-6479 (1998).
41. Franksson, L. et al. Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C. Eur. J. Immunol. 29, 2748-2758 (1999).
42. Valés-Gomez, M., Reyburn, H. T., Erskine, R. A., López-Botet, M. & Strominger, J. L. Kinetics and peptide dependency on the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J. 18, 4250-4260 (1999).
43. d interact with NK and T cell receptors. J. Immunol. 163, 3699-3708 (1999).
44. Bendelas, A., Rivera, M. N., Park, S.-H. & Roark, J. H. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15, 535-562 (1997).
45. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-327 (1997).
46. Navaza, J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157-163 (1994).
47. Brünger, A. T. et al. Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921 (1998).
48. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building models in electron density maps and the location of errors in those models. Acta Crystallogr. A 47, 110-119 (1991).
49. Esnouf, R. M. An extensively modified version of Molscript that includes greatly enhanced colouring capabilities. J. Mol. Graph. 15, 133-138 (1997).
50. Merrit, E. A. & Bacon, D. J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277, 505-524 (1997).