Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents

Biochemical Pharmacology

Volumn 51, Issue 9, 1996, Pages 1221-1228

  Wang, Gang ^a   Weiss, Clifford ^b   Sheng, Peihua ^c   Bresnick, Edward ^c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Dartmouth College   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Alkylating agents; DNA repair; Drug resistance; Gene transfer; Methylation; MGMT; Retrovirus

Indexed keywords

6 O BENZYLGUANINE; ALKYLATING AGENT; CARMUSTINE; CHLOROETHYLNITROSOUREA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITRONITROSOGUANIDINE; METHYLNITROSOUREA; TEMOZOLOMIDE;

ANIMAL CELL; ARTICLE; CELL CLONE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DRUG RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CELL LINE; DACARBAZINE; DRUG RESISTANCE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; METHYLTRANSFERASES; MICE; MOLONEY MURINE LEUKEMIA VIRUS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 0029877214     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00077-9     Document Type: Article

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