[C-11]N-methylhomoepibatidine: Radiolabelling and biodistribution studies in mice

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 43, Issue 2, 2000, Pages 127-136

  Patt, J T ^a   Spang, J E ^a   Westera, G ^a   Schubiger, P A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Epibatidine; Homoepibatidine; nAChR; Nicotinic receptor

Indexed keywords

BIODISTRIBUTIONS; BRAIN UPTAKE; EPIBATIDINE; HOMOEPIBATIDINE; IODOMETHANE; NACHR; NICOTINIC RECEPTOR; RADIOCHEMICAL SYNTHESIS; RADIOCHEMICAL YIELD; RADIOLABELLING;

MAMMALS;

CARBON 11; EPIBATIDINE; METHYL IODIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; ISOTOPE LABELING; MOUSE; NONHUMAN; PARTITION COEFFICIENT; RADIOACTIVITY; RECEPTOR BINDING; SYNTHESIS;

ANIMALIA;

EID: 0033968873     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(200002)43:2<127::AID-JLCR299>3.0.CO;2-U     Document Type: Article

References (35)

1. Arneric S.P., Sullivan J.P., Briggs C.A., Donnelly Roberts D., Anderson D.J., Raszkiewicz J.L., Hughes M.L., Cadman E.D. and Adams P. J. Pharmacol. Exp. Ther. 270: 310-318 (1994).
2. Decker M.W., Curzon P., Brioni J.D. and Arneric S.P. Eur. J. Pharmacol. 261: 217-222 (1994).
3. Maggio R., Riva M., Vaglini F., Fornai F., Racagni G. and Corsini G.U. J. Neural. Transm. 104: 1113-1123 (1997).
4. Cosford N.D., Bleicher L., Herbaut A., McCallum J.S., Vernier J.M., Dawson H., Whitten J.P., Adams P., Chavez Noriega L., Correa L.D., Crona J.H., Mahaffy L.S., Menzaghi F., Rao T.S., Reid R., Sacaan A.I., Santori E., Stauderman K.A., Whelan K., Llo'yd G.K. and McDonald I.A. J. Med. Chem. 39: 3235-3237 (1996).
5. Day J. and Fibiger H.C. Synapse. 12: 281-6 (1992).
6. Day J. and Fibiger H.C. Neuroscience. 54: 643-8 (1993).
7. McConville B.J., Fogelson M.H., Norman A.B., Klykylo W.M., Manderscheid P.Z., Parker K.W. and Sanberg P.R. Am. J. Psychiatry. 148: 793-794 (1991).
8. Silver A.A. and Sanberg P.R. Lancet. 342: 182 (1993).
9. Adler I., Pachtman E., Franks R., Pechevich M., Waldo M. and Freedman R. Biol. Psychiat. 32: 607-616 (1992).
10. Brioni J.D., AB O.N., Kim D.J., Buckley M.J., Decker M.W. and Arneric S.P. J Pharmacol Exp Ther. 271: 353-361 (1994).
11. Rose J.E., Behm F.M., Westman E.C., Levin E.D., Stein R.M. and Ripka G.V. Clin. Pharmacol. Ther. 56: 86-99 (1994).
12. Sullivan J.P. and Bannon A.W. CNS Drug Rev. 2: 21-39 (1996).
13. Buccafusco J.J., Jackson W.J., Terry A.V., Jr., Marsh K.C., Decker M.W. and Arneric S.P. Psychopharmacology Berl. 120: 256-66 (1995).
14. Curzon P., Brioni J.D. and Decker M.E. Brain Res. 714: 185-191 (1996).
15. Vidal C. Mol. Chem. Neuropathol. 28: 3-11 (1996).
16. Spang J.E., Patt J.T., Westera G. and Schubiger P.A. J. Labelled Compd. Rad. in press: (1999).
17. Patt J.T., Westera G., Buck A., Fletcher S.R. and Schubiger P.A. J. Labelled Compd. Rad. 37: 355-356 (1995).
18. Dolle F., Valette H., Bottlaender M., Hinnen F., Vaufrey F., Guenther I. and Crouzel C. J. Labelled Compd. Rad. 41: 451-463 (1998).
19. Kassiou M., Ravert H.T., Mathews W.B., Musachio J.L., London E.D. and Dannals R.F. J. Labelled Compd. Rad. 39: 425-431 (1997).
20. Horti A.G., Scheffel U., Koren A.O., Ravert H.T., Mathews W.B., Musachio J.L., Finley P.A., London E.D. and Dannals R.F. Nucl. Med. Biol. 25 (7): 599-603 (1998).
21. Musachio J.L., Villemagne V.L., Scheffel U., Stathis M., Finley P., Horti A., London E.D. and Dannals R.F. Synapse. 26: 392-399 (1997).
22. Ding Y.S., Liang F., Fowler J.S., Kuhar M.J. and Carrol F.I. J. Labelled Compd. Rad. 39: 827-832 (1997).
23. Liang F., Navarro H.A., Abraham P., Kotian P., Ding Y.S., Fowler J., Volkow N., Kuhar M.J. and Carroll F.I. J. Med. Chem. 40: 2293-2295 (1997).
24. Patt J.T., Spang J.E., Westera G., Buck A. and Schubiger P.A. Nucl. Med. Biol. 26: 165-173 (1999).
25. Bai D., Xu R., Chu G. and Zhu X. J. Org. Chem. 61: 4600-4606 (1996).
26. Malpass J.R., Hemmings D.A. and Wallis A.L. Tetrahedron Lett. 37: 3911-3914 (1996).
27. Xu R., Bai D., Chu G., Tao J. and Zhu X. Bioorg. Med. Chem. Lett. 6: 279-82 (1996).
28. Leo A., Hansch C. and Elkins D. Chem. Rev. 71: 525-616 (1971).
29. Abraham H.M. and Chadha H.S. In "Lipophilicity in Drug Action and Toxicology"; V. Pliska, B. T., H. van de Waterbeemd, Ed.; VCH: Weinheim, New York, Basel, Cambridge, Tokyo, 1996; Vol. 4.
30. Scherrer R.A. and Howard S.M. J. Med. Chem. 20: 53-58 (1977).
31. Seiler P. Eur. J. Med. Chem. 9: 473-479 (1974).
32. Abraham M.H., Chadha H.S. and Mitchell R.C. J. Pharm. Sci. 83: 1257-1268 (1994).
33. Young R.C., Mitchell R.C., Brown T.H., Ganellin C.R., Griffiths R., Jones M., Rana K.K., Saunders D., Smith I.R., Sore N.E. and et al. J. Med. Chem. 31: 656-71 (1988).
34. Dischino D.D., Welch M.J., Kilbourn M.R. and Raichel M.E. J. Nucl. Med. 24: 1030-1083 (1983).
35. Larsen P., Ulin J., Dahlstrøm K. and Jensen M. Appl. Radiat. Isot. 48: 153-157 (1997).