Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis

Nature Biotechnology

Volumn 18, Issue 9, 2000, Pages 974-979

  Chattergoon, Michael A ^a   Kim, J Joseph ^a   Yang, Joo Sung ^b   Robinson, Tara M ^a   Lee, Daniel J ^a   Dentchev, Tzvete ^a   Wilson, Darren M ^a   Ayyavoo, Velpandi ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Apoptosis; Cytotoxic T lymphocytes; Dendritic cells; Fas; Vaccines

Indexed keywords

CHEMOKINE; CYTOKINE; FAS ANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; HELPER CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY;

ANIMALS; ANNEXIN A5; ANTIGEN-PRESENTING CELLS; ANTIGENS; ANTIGENS, CD95; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; DENDRITIC CELLS; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INTERFERON TYPE II; INTERLEUKIN-12; LYMPH NODES; MALE; MICE; MICE, INBRED BALB C; MUSCLES; PLASMIDS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TIME FACTORS; TRANSFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0034425778     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/79470     Document Type: Article

References (30)

1. The immune system evolved to discriminate infectious nonself from noninfectious self
2. Tolerance, danger, and the extended family
3. Natural adjuvants: Endogenous activators of dendritic cells
4. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
5. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
6. Dendritic cell/macrophage prescursors capture exogenous antigen for MHC class I presentation by dendritic cells
7. Intracellular adhesion molecule-1 (ICAM-1) modulates β-chemokines and provides costimulatory signals required for T-cell activation and expansion in vivo
8. CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines
9. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes
10. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages
11. CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo
12. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T-cells after gene gun immunization
13. Facilitated DNA inoculation induces anti-HIV immunity in vivo
14. Induction of broadly cross-reactive cytotoxic T-cells recognizing an HIV- 1 envelope determinant
15. Broad recognition of cytotoxic T-cell epitopes from the HIV- 1 envelope protein with multiple class I histocompatibility molecules
16. The interferon-macrophage alliance
17. Acquisition of lymphokine-producing phenotype by CD4+ T-cells
18. Dendritic cells and the control of immunity
19. Induction of antitumor immunity using bone marrow-generated dendritic cells
20. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity
21. Bone marrow-derived dendritic cells serve as potent adjuvants for peptide-based antitumor vaccines
22. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
23. Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen
24. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
25. The Fas death factor
26. Monoclonal antibody-mediated tumor regression by induction of apoptosis
27. TCR/CD3 coupling to Fas-based cytotoxicity
28. An innate sense of danger
29. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
30. Molecular and immunological analysis of genetic prostate-specific antigen