Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen β-galactosidase and the BALB/c Meth A p53 tumor-specific antigen

Gene Therapy

Volumn 6, Issue 4, 1999, Pages 629-636

  Tuting T ^a,b   Gambotto, A ^c   Robbins, P D ^c   Storkus, W J ^c   DeLeo, A B ^a,c  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cell mediated immunity; DNA immunization; IFN ; IL 12; Tumor immunotherapy

Indexed keywords

ALPHA INTERFERON; ANTIBODY; BETA GALACTOSIDASE; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 12; PLASMID DNA; PROTEIN P53; TUMOR ANTIGEN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CANCER IMMUNOTHERAPY; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE GUN; GENE TARGETING; GENE TRANSFER; HELPER CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BETA-GALACTOSIDASE; BIOLISTICS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; GENES, P53; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; NEOPLASMS; SKIN; T-LYMPHOCYTES; TH1 CELLS; VACCINES, DNA;

ADENOVIRIDAE; ANIMALIA;

EID: 0344061572     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300859     Document Type: Article

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