Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen

Journal of Immunology

Volumn 166, Issue 9, 2001, Pages 5733-5740

  Hung, C F ^a   Cheng, W F ^a   Chai, C Y ^a   Hsu, K F ^a   He, L ^a   Ling, M ^a   Wu, T C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DNA VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DRUG POTENCY; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

EID: 0035340174     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.9.5733     Document Type: Article

References (31)

1. Nucleic acid malaria vaccines: Current status and potential
2. DNA vaccines
3. DNA vaccines: Immunology, application, and optimization
4. Intercellular trafficking and protein delivery by a herpesvirus structural protein
5. Intercellular delivery of functional p53 by the herpesvirus protein VP22
6. Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22
7. Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs
8. Targeting HPV-16 E7 to the endosomal/ lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine HPV-16 E7-expressing tumors
9. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene
10. Engineering an intracellular pathway for MHC class II presentation of HPV-16 E7
11. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
12. In vivo protein transduction: Delivery of a biologically active protein into the mouse
13. Genetic engineering of proteins with cell membrane permeability
14. The third helix of the Antennapedia homeodomain translocates through biological membranes
15. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
16. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
17. A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes
18. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
19. In vivo priming by DNA injection occurs predominantly by antigen transfer
20. Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity
21. Immunology of the human papilloma virus in relation to cancer
22. + lymphocytes
23. Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide
24. DNA-based immunization by in vivo transfection of dendritic cells
25. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
26. Enhancement of sindbis virus self-replicating RNA vaccine potency by linkage of herpes simplex virus type 1 VP22 protein to antigen
27. + T cells after gene gun immunization
28. DNA vaccination: Transfection and activation of dendritic cells as key events for immunity
29. Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations
30. Identification and characterization of a cDNA clone derived from the Marek's disease tumour cell line RPL1 encoding a homologue of α-transinducing factor (VP16) of HSV-1
31. Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: High-level expression and characterization of MDV-1 VP22 and VP16