A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm

Cellular and Molecular Life Sciences

Volumn 58, Issue 8, 2001, Pages 1105-1112

  Izaurralde, E ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

CTE; Nuclear export; NXF; NXT; p15; TAP

Indexed keywords

CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; KARYOPHERIN; MESSENGER RNA; ABC TRANSPORTER; CAENORHABDITIS ELEGANS PROTEIN; CELL RECEPTOR; MESSENGER RIBONUCLEOPROTEIN; NUCLEAR PROTEIN; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; NXF 1 PROTEIN, C ELEGANS; NXF-1 PROTEIN, C ELEGANS; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; TAP1 PROTEIN, HUMAN; VIRUS RNA;

BIOGENESIS; CELL MEMBRANE TRANSPORT; CYTOPLASM; DNA REPLICATION; EUKARYOTIC CELL; NONHUMAN; PROTEIN FAMILY; PROTEIN SYNTHESIS; REVIEW; ACTIVE TRANSPORT; ANIMAL; ARTICLE; AWARDS AND PRIZES; BINDING SITE; CELL NUCLEUS; DIMERIZATION; GERMANY; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AWARDS AND PRIZES; BINDING SITES; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CELL NUCLEUS; CONSERVED SEQUENCE; CYTOPLASM; DIMERIZATION; GERMANY; HUMANS; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RIBONUCLEOPROTEINS; RNA, MESSENGER; RNA, VIRAL; RNA-BINDING PROTEINS;

EID: 0034870519     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00000924     Document Type: Review

References (56)

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8. A look at messenger RNP moving through the nuclear pore
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10. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
11. Monomethylated cap structures facilitate RNA export from the nucleus
12. A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing
13. Mex67p, a novel factor for nuclear mRNA rexport binds to both poly(A)+ RNA and nuclear pores
14. GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
15. A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton
16. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A) + RNA
17. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the Nuclear Pore Complex through multiple domains
18. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture
19. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
20. Overexpression of human TAP/NXF1 bypasses nuclear retention and stimulates mRNA nuclear export
21. Regulation of mRNA expression in HIV-1 and other retroviruses
22. CRM 1 is an export receptor for leucine-rich nuclear export signals
23. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA
24. The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function
25. TAP, the human homologue of Mex67p, mediates CTE-dependent RNA export from the nucleus
26. The simian retrovirus-1 constitutive transport element CTE, unlike HIV-1 RRE, utilises factors required for cellular RNA export
27. The constitutive transport element (CTE) of Mason-Pfizer Monkey Virus (MPMV) accesses an RNA export pathway utilized by cellular messenger RNAs
28. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
29. A novel domain reveals details of the TAP/p15 interaction in nuclear export
30. The structure of the mRNA nuclear export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain
31. Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export
32. The mRNA export in C. elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF1 and S. cerevisiae Mex67p
33. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus
34. The human TAP protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
35. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
36. Yralp, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
37. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
38. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
39. The acute myeloid leukemia-associated protein DEK forms a splicing-dependent interaction with exon-product complexes
40. The SRm160/300 splicing coactivator is required for exon-enhancer function
41. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
42. Splicing is required for rapid and efficient mRNA export in metazoans
43. Identification of an NTF2-related factor that binds RanGTP and regulates nuclear protein export
44. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export
45. Identification of novel import and export signals of human TAP, the protein that binds to the CTE element of the type D retrovirus mRNAs
46. The GLFG region of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex
47. Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins
48. Deciphering the cellular pathway for transport of poly(A)-binding protein II
49. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
50. Nucleocytoplasmic shuttling signals: Two for the price of one
51. Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer Monkey Virus constitutive transport element
52. Dbp5p, a cytosolic RNA helicase, is required for poly(A) + RNA export
53. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
54. Dbp5, a DEAD box-protein required for mRNA export, is recruited to the cytoplasmic fibrils of Nuclear Pore Complex via a conserved interaction with CAN/Nup159p