The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 5998-6011

  Tabernero, Carlos ^a   Zolotukhin, Andrei S ^a   Valentin, Antonio ^a   Pavlakis, George N ^a   Felber, Barbara K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL FREE SYSTEM; GENE DELETION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; MOLECULAR CLONING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RETROVIRUS; RNA STRUCTURE; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS REPLICATION;

EID: 0029793571     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.5998-6011.1996     Document Type: Article

References (37)

1. Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson. and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
2. Arrigo, S. J., and I. S. Y. Chen. 1991. Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and envlvpu 2 RNAs. Genes Dev. 5:808-819.
3. Bartel, D., M. Zapp, M. Green, and J. Szostak. 1991. HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell 67:529-536.
4. Bray, M., S. Prasad, J. W. Dubay, E. Hunter, K-T. Jeans, D. Rekosh, and M.-L. Hammarskjold. 1994. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA 91:1256-1260.
5. Cochrane, A. W., K. S. Jones, S. Beidas, P. J. Dillon, A. M. Skalka, and C. A. Rosen, 1991. Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression. J. Virol. 65:5305-5313.
6. Cook, K. S., G. J. Fisk, J. Hauber, N. Usman, T. J. Daly, and J. R. Rusche. 1991. Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate. Nucleic Acids Res. 19:1577-1583.
7. Cullen, B. R., and M. H. Malim. 1991. The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators. Trends Biochem. Sci. 16:346-350.
8. D'Agostino, D. M., V. Ciminale, G. P. Pavlakis, and L. Chieco-Bianchi. 1995. Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention. AIDS Res. Hum. Retroviruses 11:1063-1071.
9. D'Agostino, D. M., B. K. Felber, J. E. Harrison, and G. N. Pavlakis. 1992. The Rev protein of human immunodeficiency virus type 1 promotes polyso mal association and translation of gag/pol and vpu/env mRNA. Mol. Cell. Biol. 12:1375-1386.
10. de Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
11. Emerman, M., R. Vazeux, and K. Peden. 1989. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell 57:1155-1165.
12. Felber, B. K., M. Hadzopoulou-Cladaras, C. Cladaras, T. Copeland, and G. N. Pavlakis. 1989. rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc. Natl. Acad. Sci. USA 86:1495-1499.
13. Felber, B. K., and G. N. Pavlakis. 1993. Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression. AIDS 7(Suppl.):S51-S62.
14. Gardner, M. B., M. Endres, and P. Barry. 1994. The simian retroviruses SIV and SRV, p. 133-276. In J. A. Levy (ed.), The Retroviridae. Plenum Press, New York.
15. Graham, F. J., and A. J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-460.
16. Hammarskjöld, M. L., J. Heimer, B. Hammarskjöld, I. Sangwan, L. Albert, and D. Rekosh. 1989. Regulation of human immunodeficiency virus env expression by the rev gene product. J. Virol. 63:1959-1966.
17. Harrison, G. P., E. Hunter, and A. M. L. Lever. 1995. Secondary structure model of the Mason-Pfizer monkey virus 5′ leader sequence: identification of a structural motif common to a variety of retroviruses. J. Virol. 69:2175-2186.
18. Heaphy, S., C. Dingwall, I. Ernberg, M. J. Gait, S. M. Green, J. Karn, A. D. Lowe, M. Singh, and M. A. Skinner. 1990. HIV-1 regulator of virion expres sion (Rev) protein hinds to an RNA stem-loop structure located within the Rev response element region. Cell 60:685-693.
19. Heidecker, G., N. W. Lerche, L. J. Lowenstine, A. A. Lackner, K. G. Osborn, M. B. Gardner, and P. A. Marx. 1987. Induction of simian acquired immune deficiency syndrome (SAIDS) with a molecular clone of a type D SAIDS retrovirus. J. Virol. 61:3066-3071.
20. Holland, S. M., M. Chavez, S. Gerstberger, and S. Venkatesan. 1992. A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev. J. Virol. 66:3699-3706.
21. Lawrence, J. B., A. W. Cochrane, C. V. Johnson, A. Perkins, and C. A. Rosen. 1991. The HIV-1 Rev protein: a model system for coupled RNA transport and translation. New Biol. 3:1220-1232.
22. Maldarelli, F., M. A. Martin, and K. Strebel. 1991. Identification of post-transcriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation. J. Virol. 65:5732-5743.
23. Malim, M. H., J. Hauber, S.-Y. Le, J. V. Maizel, and B. R. Cullen. 1989. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature (London) 338:254-257.
24. Mermer, B., B. K. Felber, M. Campbell, and G. N. Pavlakis. 1990. Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells. Nucleic Acids Res. 18:2037-2044.
25. Myers, G., B. Korber, J. A. Berzofsky, R. Smith, and G. N. Pavlakis. 1991 Human retroviruses and AIDS. A compilation and analysis of nucleic acid and amino acid sequences. Los Alamos National Laboratory, Los Alamos. N.Mex.
26. Nasioulas, G., and B. K. Felber. Unpublished data.
27. Nasioulas, G., A. S. Zolotukhin, C. Tabernero, L. Solomin, C. P. Cunningham, G. N. Pavlakis, and B. K. Felber. 1994. Elements distinct from the human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA. J. Virol. 68:2986-2993.
28. Parslow, T. C. 1993. Post-transcriptional regulation of human retroviral gene expression, p. 101-136. In B. R. Cullen (ed.). Human retroviruses. IRL Press. Oxford.
29. Power, M. D., P. A. Marx, M. L. Bryant, M. B. Gardner, P. J. Bark, and P. A. Luciw. 1986. Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science 231:1567-1572.
30. Rosen, C. A., E. Terwilliger, A. Dayton, J. G. Sodroski, and W. A. Haseltine. 1988. Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 85:2071-2075.
31. Schwartz, S., B. K. Felber, D. M. Benko, E. M. Fenyö, and G. N. Pavlakis. 1990. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J. Virol. 64:2519-2529.
32. Schwartz, S., B. K. Felber, and G. N. Pavlakis. 1992. Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein. J. Virol. 66:150-159.
33. Solomin, L., B. K. Felber, and G. N. Pavlakis. 1990. Different sites of interaction for Rev, Tev, and Rex proteins within the Rev responsive element of human immunodeficiency virus type 1. J. Virol. 64:6010-6017.
34. Sonigo, P., C. Barker, E. Hunter, and S. Wain-Hobson. 1986. Nucleotide sequence of Mason-Pfizer monkey virus: an immunosuppressive D-type retrovirus. Cell 45:375-385.
35. Thayer, R. M., M. D. Power, M. L. Bryant, M. B. Gardner, P. J. Barr, and P. A. Luciw. 1987. Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology 157:317-329.
36. Zolotukhin, A. S., J. B. Harford, and B. K. Felber. 1994. Rev of human immunodeficiency virus and Rex of the human T-cell leukemia virus type I can counteract a cellular RNA instability element of the transferrin receptor mRNA. Nucleic Acids Res. 22:4725-4732.
37. Zolotukhin, A. S., A. Valentin, G. N. Pavlakis, and B. K. Felber. 1994. Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. J. Virol. 68:7944-7952.