BRCA2 and homologous recombination

Breast Cancer Research

Volumn 3, Issue 5, 2001, Pages 294-298

  Orelli, B J ^a   Bishop, D K ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Breast cancer; Homologous recombination

Indexed keywords

BRCA2 PROTEIN; DNA; DOUBLE STRANDED DNA; RAD51 PROTEIN;

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; DNA REPAIR; DNA STRAND BREAKAGE; GENE FUNCTION; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MODEL; PROTEIN INTERACTION; REVIEW;

BRCA2 PROTEIN; BREAST NEOPLASMS; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; NEOPLASM PROTEINS; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS;

EID: 0034856461     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr310     Document Type: Article

References (31)

1. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
2. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein
3. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
4. Identification of the breast cancer susceptibility gene BRCA2
5. Involvement of Brca2 in DNA repair
6. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
7. The BRC repeats are conserved in mammalian BRCA2 proteins
8. Internal repeats in the BRCA2 protein sequence
9. Association of BRCA1 with Rad51 in mitotic and meiotic cells
10. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
11. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
12. In situ visualization of DNA double-strand break repair in human fibroblasts
13. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage
14. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
15. Lessons learned from BRCA1 and BRCA2
16. RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein
17. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
18. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
19. The BRCA2 gene product functionally interacts with p53 and RAD51
20. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
21. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
22. Brca1 controls homology-directed DNA repair
23. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
24. BRCA2 is required for homology-directed repair of chromosomal breaks
25. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
26. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
27. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
28. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
29. DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA
30. Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis
31. Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs