Triazolam substrate inhibition: Evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Drug Metabolism and Disposition

Volumn 29, Issue 1, 2001, Pages 70-75

  Schrag, Michael L ^a   Wienkers, Larry C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' HYDROXYTRIAZOLAM; 4 HYDROXYTRIAZOLAM; CYTOCHROME B5; CYTOCHROME P450 3A4; DRUG METABOLITE; DRUG METABOLIZING ENZYME; REACTIVE OXYGEN METABOLITE; TRIAZOLAM; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; KINETICS; LIVER MICROSOME; MODEL; PRIORITY JOURNAL; REACTION ANALYSIS; REACTION TIME;

BINDING SITES; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HEME; HUMANS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXYGEN; TRIAZOLAM;

EID: 0035148967     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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