Dissecting the molecular mechanism of nuclear receptor action: Transcription coactivators and corepressors

Experimental and Molecular Medicine

Volumn 32, Issue 2, 2000, Pages 53-60

  Lee, Jae Woon ^a,b   Cheong, JaeHun ^a,b   Lee, Young Chul ^a,b   Na, Soon Young ^a,c   Lee, Soo Kyung ^a,c  

^a Center for Ligand and Transcription   (South Korea)

^b Hormone Research Center   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

Coactivators; Compressors; Nuclear receptor; Transcription

Indexed keywords

CELL NUCLEUS RECEPTOR; PROTEIN P160; PROTEIN P300; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

MOLECULAR BIOLOGY; REVIEW; TRANSACTIVATION;

EID: 0034733736     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2000.10     Document Type: Review

References (74)

1. Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M. M., Guan, X. Y., Sauter, G., Kallioniemi, O. P., Trent, J. M. and Meltzer, P. S. (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277: 965-968
2. Bailey, P., Downes, M., Lau, P., Harris, J., Chen, S. L., Hamamori, Y., Sartorelli, V. and Muscat, G. E. (1999) The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD. Mol. Endocrinol. 13: 1155-1168
3. Bannister, A. J. and Kouzarides, T. (1996) The CBP coactivator is a histone acetyltransferase. Nature 384: 641-643
4. Blanco, J. C. G., Minucci, S., Lu, J. M., Yang, X. J., Walker, K. K., Chen, H. W., Evans, R. M., Nakatani, Y. and Ozato, K. (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes. Dev. 12: 1638-1651
5. Boyes, J., Byfield, P., Nakatani, Y. and Ogryzko, V. (1998) Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396: 594-598
6. Caira, F., Antonson, P., Pelto-Huikko, M., Treuter, E. and Gustafsson, J. A. (2000) Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275: 5308-5317
7. Chen, J. D. and Evans, R. M. (1995) A transcriptional corepressor that interacts with nuclear hormone receptors. Nature 377: 454-457
8. Chen, H. W., Lin, R. J., Schilz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y. and Evans, R. M. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580
9. Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R. and Goodman, R. H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855-859
10. Darimont, B. D., Wagner, R. L., Apriletti, J. W., Stallcup, M. R., Kushner, P. J., Baxter, J. D., Fletterick, R. J. and Yamamoto, K. R. (1998) Structure and specificity of nuclear receptor-coactivator interactions. Genes. Dev. 12: 3343-3356
11. Dhordain, P., Albagli, O., Lin, R. J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J. P., Evans, R. M. and Leprince, D. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94: 10762-10767
12. Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B. and Livingston, D. M. (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kd protein(p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8: 869-884
13. Endoh, H., Maruyama, K., Masuhiro, Y., Kobayashi, Y., Goto, M., Tai, H., Yanagisawa, J., Metzger, D., Hashimoto, S. and Kato, S. (1999) Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol. Cell. Biol. 19: 5363-5372
14. Fondell, J. D., Ge, H. and Roeder, R. G. (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. USA 93: 8329-8333
15. Ge, H., Si, Y. and Wolffe, A. P. (1998) A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell 2: 751-759
16. Goldman, P. S., Tran, V. K. and Goodman, R. H. (1997) The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 52: 103-120
17. Grant, P. A., Duggan, L., Cote, J., Roberts, S. M., Brownell, J. E., Candau, R., Ohba, R., Owen-Hughes, T., Allis, C. D., Winston, F., Berger, S. L. and Workman, J. L. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev. 11: 1640-1650
18. Gu, W. and Roeder, R. G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90: 595-606
19. Guan, X. Y., Xu, J., Anzick, S. L., Zhang, H., Trent, J. M. and Meltzer, P. S. (1996) Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res. 56: 3446-3450
20. Heery, D. M., Kalkhoven, E., Hoare, S. and Parker, M. G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387: 733-736
21. Heinzel, T., Lavinsky, R. M., Mullen, T. M., Soderstrom, M., Laherty, C. D., Torchia, J., Yang, W. M., Brard, G., Ngo, S. D., Davie, J. R., Seto, E., Eisenman, R. N., Rose, D. W., Glass, C. K. and Rosenfeld, M. G. (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387: 43-48
22. Hong, H., Koli, K., Garbedian, M. J. and Stallcup, M. R. (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17: 2735-2744
23. Horlein, A. J., Naar, A. M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamei, Y., Soderstrom, M., Glass, C. K. and Rosenfeld, M. G. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor. Nature 377: 397-404
24. Horwitz, K. B., Jackson, T. A., Bain, D. L., Richer, J. K., Takimoto, G. S. and Tung, L. (1996) Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10: 1167-1177
25. Hu, X. and Lazar, M. A. (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402: 93-96
26. Imhof, A., Yang, X. J., Ogryzko, V. V., Nakatani, Y., Wolffe, A. P. and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7: 689-692
27. Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S. C., Heyman, R. A., Rose, D. W., Glass, C. K. and Rosenfeld, M. G. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414
28. Kawasaki, H., Eckner, R., Yao, T. P., Taira, K., Chiu, R., Livingston, D. M. and Yokoyama, K. K. (1998) Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393: 284-289
29. Kim, Y. J., Bjorklund, S., Li, Y., Sayre, M. H. and Kornberg, R. D. (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77: 599-608
30. Kim, H. J., Lee, S. K., Na, S. Y., Choi, H. S. and Lee, J. W. (1998) Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2. Mol. Endocrinol. 12: 1038-1047
31. Kim, H. J., Kim, J. H. and Lee, J. W. (1998a) Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations. J. Biol. Chem. 273: 28564-28567
32. Kim, H. J., Yi, J. Y., Sung, H. S., Moore, D. D., Jhun, B. H., Lee, Y. C. and Lee, J. W. (1999) ASC-1, as a novel transcription coactivator of nuclear receptors, and its cytosolic localization under serum-deprivation. Mol. Cell. Biol., in press.
33. Ko, L., Cardona, G. R. and Chin, W. W. (2000) Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc. Natl. Acad. Sci. USA 97: 6212-6217
34. Korzus, E., Torchia, J., Rose, D. W., Xu, L., Kurokawa, R., McInerney, E. M., Mullen, T. M., Glass, C. K. and Rosenfeld, M. G. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279: 703-707
35. Kraus, W. L. and Kadonaga, J. T. (1998) p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. Genes Dev. 12: 331-342
36. Laherty, C. D., Billin, A. N., Lavinsky, R. M., Yochum, G. S., Bush, A. C., Sun, J. M., Mullen, T. M., Davie, J. R., Rose, D. W., Glass, C. K., Rosenfeld, M. G., Ayer, D. E. and Eisenman, R. N. (1998) SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcripgion factors. Mol. Cell 2: 33-42
37. Laherty, C. D., Yang, W. M., Sun, J. M., Davie, J. R., Seto, E. and Eisenman, R. N. (1997) Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell 89: 349-356
38. Lai, A., Lee, J. M., Yang, W. M., DeCaprio, J. A., Kaelin, W. G. Jr., Seto, E. and Branton, P. E. (1999) RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol. Cell. Biol. 19: 6632-6641
39. Lee, J. W., Choi, H. S., Gyuris, J., Brent, R. and Moore, D. D. (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol. Endocrinol. 9: 243-254
40. Lee, S. K., Kim, H. J., Na, S. Y., Kim, T. S., Choi, H. S., Im, S. Y. and Lee, J. W. (1998) Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J. Biol. Chem. 273: 16651-16654
41. Lee, S. K., Kim, H. J. and Lee, J. W. (1999) SRC-1 and its family members differentially regulate transactivation by the tumor suppressor p53. Mol. Endocrinol. 13: 1924-1933
42. Lee, S. K., Anzick, S. L., Choi, J. E., Bubendorf, L., Guan, X. Y., Jung, Y. K., Kallioniemi, O. P., Kononen, J., Trent, J. M., Azorsa, D., Jhun; B. H., Meltzer, P. S. and Lee, J. W. (1999a) ASC-2, a novel transcriptional coactivator of nuclear receptors and its amplification in human cancers. J. Biol. Chem. 274: 34283-34293
43. Lee, S.-K., Na, S.-Y., Jung, S.-Y., Jhun, B. H., Cheong, J. H., Meltzer, P. S., Lee, Y. C. and Lee, J. W. (2000) Activating protein-1, nuclear factor-κB and serum response factor, as novel target molecules of the cancer-amplified transcription coactivator ASC-2. Mol. Endocrinol. 14: 915-925
44. Lee, S.-K., Kim, J.-H., Lee, Y. C., Cheong, J. and Lee, J. W. (2000a) Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-κB and serum response factor. J. Biol. Chem. 275: 12470-12474
45. Lee, S-.K., Jung, S-.Y., Na, S-.Y., Cheong, J., Lee, Y. C. and Lee, J. W. Two Distinct Nuclear Receptor-Interaction Domains and CREB-Binding Protein-Dependent Transactivation Function of Activating Signal Cointegrator-2. Mol. Endocrinol., submitted.
46. Li, Y., Bjorklund, S., Jiang, Y. W., Kim, Y. J., Lane, W. S., Stillman, D. J. and Kornberg, R. D. (1995) Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 92: 10864-10868
47. Li, J., O'Malley, B. W. and Wong, J. (2000) p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin. Mol. Cell. Biol. 20: 2031-2042
48. Lin, R. J., Nagy, L., Inoue, S., Shao, W., Miller, W. H. Jr. and Evans, R. M. (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391: 811-814
49. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P. and Evans, R. M. (1995). The nuclear receptor superfamily: the second decade. Cell 83: 835-839
50. McKenna, N. J., Nawaz, Z., Tsai, S. Y., Tsai, M. J. and O'Malley, B. W. (1998) Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc. Natl. Acad. Sci. USA 95: 11697-11702
51. Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G. and Thanos, D. (1998) Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol. Cell. 2: 457-467
52. Na, S. Y., Lee, S. K., Han, S. J., Choi, H. S., Im, S. Y. and Lee, J. W. (1998) Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor κB-mediated transactivations. J. Biol. Chem. 273: 10831-10834
53. Naar, A. M., Beaurang, P. A., Zhou, S., Abraham, S., Solomon, W. and Tjian, R. (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398: 828-832
54. Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L. and Evans, R. M. (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89: 373-380
55. Nakajima, T., Uchida, C., Anderson, S. F, Lee, C. G., Hurwitz, J., Parvin, J. D. and Montminy, M. (1997) RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90: 1107-1112
56. Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K. and Milburn, M. V. (1998) Ligand binding and coactivator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395: 137-143
57. Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H. and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959
58. Ogryzko, V. V., Kotani, T., Zhang, X., Schlitz, R. L., Howard, T., Yang, X. J., Howard, B. H., Qin, J. and Nakatani, Y. (1998) Histone-like TAFs within the PCAF histone acetylase complex. Cell 94: 35-44
59. Perissi, V., Staszewski, L. M., Mclnerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., Lambert, M. H., Milburn, M. V., Glass, C. K. and Rosenfeld, M. G. (1999) Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 13: 3198-3208
60. Rachez, C., Suldan, Z., Ward, J., Chang, C. P., Burakov, D., Erdjument-Bromage, H., Tempst, P. and Freedman, L. P. (1998) A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12: 1787-1800
61. Rachez, C., Lemon, B. D., Suldan, Z., Bromleigh, V., Gamble, M., Naar, A. M., Erdjument-Bromage, H., Tempst, P. and Freedman, L. P. (1999) Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398: 824-828
62. Rowan, B. G., Weigel, N. L. and O'Malley, B. W. (2000) Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein klnase pathway. J. Biol. Chem. 275: 4475-4483
63. Spencer, T. E., Jenster, G., Burcin, M. M., Allis, C. D., Zhou, J. X., Mizzen, C. A., McKenna, N. J., Onate, S. A., Tsai, S. Y., Tsai, M. J. and O'Malley, B. W. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389: 194-198
64. Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E. and Schreiber, S. L. (1998) Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395: 917-921
65. Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K. and Rosenfeld, M. G. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684
66. Voegel, J. J., Heine, M. J. S., Tini, M., Vivat, V., Chambon, P. and Gronemeyer, H. (1998) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17: 507-519
67. Westin, S., Kurokawa, R., Nolte, R. T., Wisely, G. B., McInerney, E. M., Rose, D. W., Milburn, M. V., Rosenfeld, M. G. and Glass, C. K. (1998) Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature 395: 199-202
68. Yang, X. J., Ogryzko, V. V., Nishikawa, J., Howard, B. H. and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1a. Nature 382: 319-324
69. Yao, T. P., Ku, G., Zhou, N., Scully, R. and Livingston, D. M. (1996). The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl. Acad. Sci. USA 93: 10626-10631
70. Yao, T. P., Oh, S. P., Fuchs, M., Zhou, N. D., Ch'ng, L. E., Newsome, D., Bronson, R. T., Li, E., Livingston, D. M. and Eckner, R. (1998) Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93: 361-372
71. Zhang, Y., LeRoy, G., Seelig, H. P., Lane, W. S. and Reinberg, D. (1998) The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 95: 279-289
72. Zhang, Y., Sun, Z. W., Iratni, R., Erdjument-Bromage, H., Tempst, P., Hampsey, M. and Reinberg, D. (1998a) SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell. 1: 1021-1031
73. Zhang, W. and Bieker, J. J. (1998) Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc. Natl. Acad. Sci. USA 95: 9855-9860
74. Zhu, Y., Kan, L., Qi, C., Kanwar, Y. S., Yeldandi, A. V., Rao, M. S. and Reddy, J. K. (2000) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 275: 13510-13516