Interferon-γ secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-β therapy

Annals of Neurology

Volumn 45, Issue 2, 1999, Pages 247-250

  Becher, Burkhard ^a   Giacomini, Paul S ^a   Pelletier, Daniel ^a   McCrea, Ellie ^a   Prat, Alexandre ^a   Antel, Jack P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERFERON BETA SERINE;

ADULT; ARTICLE; CELL SECRETION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; MALE; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RELAPSE; REMISSION; T LYMPHOCYTE SUBPOPULATION;

ADULT; FEMALE; HUMANS; INTERFERON TYPE II; INTERFERON-BETA; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0032966258     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199902)45:2<247::AID-ANA16>3.0.CO;2-U     Document Type: Article

References (22)

1. Ando DG, Clayton J, Kono D, et al. Encephalitic T cells in the B10.Pl, model of experimental allergic: encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol 1989:124: 132-143
2. Racke MK, Bonomo A, Scott DE, et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994:180:1961-1966
3. Panitch HS, Hirsch RL, Schindler J, Johnson KP. Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 1987; 37:1097-1102
4. Heremans H, Dillen C, Groenen M, et al. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interrerongamma. Eur J Immunol 1996:26:2393-2398
5. Krakowski M, Owens T. Interferon-gamma confers resistance to experimental autoimmune encephalomyelitis. Eur J Immunol 1996:26:1641-1646
6. Austrup F, Vestweber D, Borges E, et al. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 1997:385:81-83
7. Bonecchi R, Bianchi G, Bordignon PP, et al. Fifferential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187:129-134
8. Zhang B, Yamamura T, Kondo T, et al. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med 1997; 186:1677-1687
9. Koh DR, Fung-Leung WP, Ho A, et al. Less mortality but more relapses in experimental autoimmune encephalomyelitis in CDS +/- mice. Science 1992:256:1210-1213
10. Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CDS+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest 1995:95:2711-2719
11. Bania MB, Antel JP, Reder AT, et al. Suppressor and cytolytic cell function in multiple sclerosis: effects of cyclosporin A and interleukin-2. J Clin Invest 1986:78:582-586
12. Antel JP, Bania MB, Reder A, Cashman N. Activated suppressor cell dysfunction in progressive multiple sclerosis. J Immunol 1986:137:137-141
13. Noronha A, Toscas A, Jensen MA. Interferon beta augments suppressor cell function in multiple sclerosis. Ann Neurol 1990; 27:207-210
14. Noronha A, Toscas A, Jensen MA. Interferon beta decreases T cell activation and interferon gamma production in multiple sclerosis. J Neuroimmunol 1993:46:145-153
15. Balashov KE, Smith DR, Khoury SJ, et al. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Prac Natl Acad Sci USA 1997:94:599-603
16. Neighbour PA, Miller AE, Bloom BR. Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis. Neurology 1981:31:561-566
17. Crucian B, Dunne P, Friedman H, et al. Alterations in peripheral blood mononuclear cell cytokine production in response to phytohemagglutinin in multiple sclerosis patients. Clin Diagn Lab Immunol 1995:2:766-769
18. Brod SA, Khan M, Bright J, et al. Decreased CD3-mediated interferon-gamma production in relapsing-remitting multiple sclerosis. Ann Neurol 1995:37:546-549
19. Crucian B. Dunne P, Friedman H, et al, Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection bu flow cytometry and surface marker analysis. Clin Diagn Lab Immunol 1996;3:411-416
20. Arnason BG. Interferon beta in multiple sclerosis. Clin Immunol Immunopathol 1996:81:1-11
21. Petereit HF, Bamborschke S, Esse AD, Heiss WD. Interferon gamma-producing blood lymphocytes are decreased by inter-feron beta therapy in patients with multiple sclerosis. Mult Scler 1997:3:180-183
22. Bongioanni MR, Durelli L, Ferrero B, et al. Systemic high-dose recombinant alpha-2a-interferon therapy modulates lymphokine production in multiple sclerosis. J Neurol Sci 1996:143:91-99