Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains

Journal of Experimental Medicine

Volumn 185, Issue 3, 1997, Pages 439-451

  Conboy, Irina M ^a   DeKruyff, Rosemarie H ^b   Tate, Keri M ^a   Cao, Zhu A ^a   Moore, Tom A ^c   Umetsu, Dale T ^b   Jones, Patricia P ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; GENETIC REGULATION; HELPER CELL; INBRED STRAIN; INTERFERON PRODUCTION; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-PRESENTING CELLS; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERFERON TYPE II; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; SPECIES SPECIFICITY; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031058034     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.3.439     Document Type: Article

References (68)

1. Mosmann, T.R., and R.L. Coffman. 1987. Two types of mouse helper T-cell clone: implications for immune regulation. Immunol. Today. 8:223-226.
2. Umetsu, D.T., H.H. Jabara, R.H DeKruyff, A.K. Abbas, J.S. Abrams, and R.S. Geha. 1988. Functional heterogeneity among human inducer T cell clones. J. Immunol. 140:4211-4216.
3. Mosmann, T.R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17: 138-146.
4. Mosmann, T.R., and R.L. Coffman. 1989. Heterogeneity of cytokine secretion patterns and function of helper T cells. Adv. Immunol. 46:111-147.
5. Parronchi, P., D. Macchia, M.-P. Piccinni, P. Biswas, C. Simonelli, E. Magi, M. Rocci, A.A. Ansari, and S. Romagnani. 1991. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl. Acad. Sci. USA. 88:4538-4542.
6. Durham, S.R., S. Ying, V.A. Varney, M.R. Jacobson, R.M. Sudderick, I.S. Mackay, A.B. Kay, and Q.A. Hamid. 1992. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J. Immunol. 148:2390-2394.
7. Ohmen, J.D., J. Hanifin, B.J. Nickoloff, T.H. Rea, R. Wyzykowski, J. Kim, D. Jullien, T. McHugh, A.S. Nassif, S.C. Chan et al., 1995. Overexpression of IL-10 in atopic dermatitis: contrasting cytokine patterns with delayed-type hypersensitivity reactions. J. Immunol. 154:1956-1963.
8. Liblau, R.S., S.M. Singer, and H.O. McDevitt. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today. 16:34-38.
9. Seder, R.A., R. Gazzinelli, A. Sher, and W.E. Paul. 1993. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
10. Wu, C.Y., C. Demeure, M. Kiniwa, M. Gately, and G. Delespesse. 1993. IL-12 induces the production of IFN-γ by neonatal human CD4 T cells. J. Immunol. 151:1938-1949.
11. Manetti, R., P. Parronchi, M.G. Giudizi, M.P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor interleukm 12 (IL-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
12. Manetti, R., F. Gerosa, M.G. Guidici, R. Biagotti, P. Parronchi, M.-P. Piccinni, S. Sampognato, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for Interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273-1283.
13. Murphy, E.E., G. Terres, S.E. Macatonia, C.-S. Hsieh, J. Mattison, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper cell 1 clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223-231.
14. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211-222.
15. Flesch, I.E.A., J.H Hess, S. Huang, M. Arguet, J. Rothe, H. Bluethmann, and S.H.E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615-1621.
16. Fiorentino, D.F., M.W. Bond, and T.R. Mosmann. 1989. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081-2095.
17. Fiorentino. D.F., A. Zlotnik, P. Vieira, T.R. Mosmann, M. Howard, K.W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444-3451.
18. Hsieh, G.-S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K. Murphy. 1992. Differential regulation of T helper phenotype development by IL-4 and IL-10 in an αβ-transgenic system. Proc. Natl. Acad. Sci. USA. 89:6065-6069.
19. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
20. Mocci, S., and R.L. Coffman. 1995. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779-3787.
21. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubier, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:665-675.
22. de Waal Malefyt, R., C.G. Fidgor, R. Huijbens, S. Mohan-Peterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski, and J.E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Companson with IL-4 and modulation by IFN-gamma or IL-10. J. Immunol. 151:6370-6381.
23. Doherty, T.M., R. Kastelein, S. Menon, S. Andrade, and R.L. Coffman. 1993. Modulation of murine macrophage function by IL-13. J. Immunol 151:7151-7160.
24. Cosentino, G., E. Soprana, C.P. Thienes, A.G. Siccardi, G. Viale, and D. Vercelli. 1995. IL-13 downregulates CD14 expression and TNF-alpha secretion in normal human monocytes. J. Immunol. 155:3145-3151.
25. Mattner, F., S. Fischer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rude, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202-2208.
26. Gillessen, S., D. Carvajal, P. Ling, F.J. Podlaski, D.L. Stremly, P.C. Familletti, U. Gubler, D. Presky, A.S. Stern, and M.K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25:200-206.
27. Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (Wash. DC). 265:1237-1240.
28. Swain, S., L.G. Huston, S. Tonkonogy, and A. Weinberg. 1991. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 147:2991-3000.
29. Nagelkerken, L., K.J. Gollob, M. Tielemans, and R.L. Coffman. 1993. Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur. J. Immunol. 23:2306-2310.
30. 2 on the Th1 cell develpment of naive CD4+ T cells isolated from different mouse strains. J. Immunol. 155:3788-3793.
31. + T cell subset activation. J. Exp. Med. 170:2135-2140.
32. + T cells. J. Exp. Med. 182:1591-1596.
33. Aubry, J.P., S. Pochon, P. Graber, K.U. Jansen, and J.Y. Bonnefoy. 1992. CD21 is a hgand for CD23 and regulates IgE production. Nature (Lond.). 358:505-507.
34. Weinberg, A.D., J.J. Wallin, R.E., Jones, T.J. Sullivan, D.N. Bourdette, A.A. Vandenbark, and H. Offner. 1994. Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cords of rats with experimental autoimmune encephalitomyelitis. J. Immunol. 152:4712-4721.
35. Del Prete, G., E. Maggi, G. Pizzolo, and S. Romagnani. 1995. CD30, Th2 cytokines and HIV infection: a complex and fascinating link. Immunol. Today. 16:76-80.
36. Elson, L.H., T.B. Nutman, D.D. Metcalfe, and C. Prussin. 1995. Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within human CD4+CD27-lymphocyte population. J. Immunol. 154:4294-4301.
37. Kuchroo, V.K., M.V. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, and L.H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease theory. Cell. 80:707-718.
38. Kamanaka, M., P. Yu, T. Yasui, K. Yoshida, T. Kawabe, T. Horii, T. Kishimoto, and H. Kikutani. 1996. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity. 4:275-281.
39. Campbell, K., P.J. Ovendale, M.K. Kennedy, W.C. Fanslow, S.G. Reed, and C.R. Maliszewski. 1996. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity. 4:283-289.
40. Soong, L., J.-C. Xu, I.S. Grewal, P. Kima, J. Sun. B.J. Longley, Jr., N.H. Ruddle, D. McMahon-Pratt, and R.A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity. 4:263-273.
41. + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081-1089.
42. Macatonia, S., N.A. Hosken, M. Litton, P. Vieira, C.-S. Hsieh, J.A. Culpepper, M. Wysocka, G. Trinchieri, K.M. Murphy, and A. O'Garra. 1995. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154:5071-5079.
43. Stockinger, B., T. Zal, A. Zal, and D. Gray. 1996. B cells solicit their own help from T cells. J. Exp. Med. 183:891-899.
44. Howard, J.G., C. Hale, and W.L. Chan-Liew. 1980. Immunological regulation of experimental cutaneous leishmaniasis. I. Immunogenetic aspects of susceptibility to Leishmania tropica in mice. Parasite Immunol. (Oxf.) 2:303-314.
45. Fritz, R.B., M.J. Skeen, C.-H.J. Chou, M. Garcia, and I.K. Egorov. 1985. Major histocompatibility complex-linked control of the marine immune response to myelin basic protein. J. Immunol. 134:2328-2332.
46. Fritz, R.B., and D.E. Mcfarlin. 1989. Encephalitogenic epitopes of myelin basic protein. Chem. Immunol. 46:101-125.
47. Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 12:151-177.
48. Vyse, T.J., and J.A Todd. 1996. Genetic analysis of autoimmune disease. Cell. 85:311-318.
49. DeKruyff, R.H., Y. Fang, and D.T. Umetsu. 1992. IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. Influence of antigen concentration and anti-gen-presenting cell type. J. Immunol. 149:3468-3476.
50. Sher, A., and R.L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385-409.
51. Guler, M.L., J.D. Gorham, C.-S. Hsieh. A.J. Mackey, R.G. Steen, W.F. Dietrich, and K.M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science (Wash. DC). 271:984-987.
52. Powell, M.B., D. Mitchell, J. Lederman, J. Buhmeier, S. Zamvil, G. Graham, N.H. Ruddle, and L. Steinman. 1990. Lymphotoxin and tumor necrosis factor-α production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539-544.
53. Ruddle, N.H., C.M. Bergman, K.M. McGrath, E.G. Lingenheld, M.L. Grunnet, S.J. Padula, and R.B. Clark. 1990. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172:1193-1200.
54. van der Veen, R.C., and S.A. Stohlman. 1993. Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin IL-4 and IL-10. J. Neuroimmunol. 48:213-220.
55. Olsson, T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:245-268.
56. + T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57-68.
57. Branch, D.R., A. Shan., and L.J. Guilbert. 1991. A specific and reliable bioassay for the detection of femtomolar levels of human and murine tumor necrosis factors. J. Immunol. Methods. 143:251-261.
58. Tate, K.M., C. Lee, S. Edelman, C. Carswell-Crumpton, R. Liblau, and P.P. Jones. 1995. Interactions among polymorphic and conserved residues in MHC class II proteins affect MHC-peptide conformation and T cell recognition. Intl. Immunol 7:747-761.
59. Zamvil, S., P. Nelson, J. Trotter, D. Mitchell, R. Knobler, R. Fritz, and L. Steinman. 1985. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature (Lond.). 317:355-358.
60. Openshaw, P., E.E. Murphy, N.A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182:1357-1367.
61. Millet, I., and N.H. Ruddle. 1994. Differential regulation of lymphotoxin (LT), lymphotoxin-β (LT-β), and TNF-α in murine T cell clones activated through the TCR. J. Immunol. 152:4336-4346.
62. DeKruyff, R.H., S. Ju, T. Mosmann, A.J. Hunt, and D.T. Umetsu. 1989. Induction of antigen specific responses in primed and unprimed B cells: functional heterogeneity among Th1 and Th2 T cell clones. J. Immunol. 142:2575-2582.
63. 2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-γ and IL-2, but not IL-4 and IL-5. J. Immunol 155:4604-1612.
64. 2 determine the IFN-γ level of activated human CD4+ T cells. J. Immunol. 156:1722-1727.
65. Stimpfling, J.H., and A.E. Reichert. 1970. Strain C57BL/ 10ScSn and its congenic resistant sublines. Transplant. Proc. 2: 39-47.
66. Klein, J. 1989. Congenic and segregating inbred strains. In Genetic Variants and Strains of the Laboratory Mouse. M.F. Lyon and A.G. Searle, editors. Oxford University Press, New-York. 797-825.
67. Hsieh, C-S., S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1995. T cell helper background determines default T helper phenotype in vitro. J. Exp. Med. 181:713-721.
68. Mitchell, G.F. 1983. Murine cutaneous leishmaniasis: resistance in reconstituted nude mice and several F1 hybrids infected with Leishmania Tropica Major. 1983. J. Immunogenet. (Oxf.). 10:395-412.