Src family tyrosine kinases and growth factor signaling

Experimental Cell Research

Volumn 254, Issue 1, 2000, Pages 1-13

  Abram, Clare L ^a   Courtneidge, Sara A ^a  

^a SUGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RHO FACTOR;

CELL MIGRATION; CYTOSKELETON; DNA SYNTHESIS; ENZYME ACTIVATION; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034627767     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4732     Document Type: Review

References (141)

1. Harder K. W., Moller N. P., Peacock J. W., Jirik F. R. Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion. J. Biol. Chem. 273:1998;31890-31900.
2. Su J., Muranjan M., Sap J. Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts. Curr. Biol. 9:1999;505-511.
3. Ponniah S., Wang D. Z., Lim K. L., Pallen C. J. Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn. Curr. Biol. 9:1999;535-538.
4. Thomas S. M., Brugge J. S. Cellular functions regulated by Src family kinases. Annu. Rev. Cell. Dev. Biol. 13:1997;513-609.
5. Stover D. R., Liebetanz J., Lydon N. B. Cdc2-mediated modulation of pp60c-src activity. J. Biol. Chem. 1994;269-26889.
6. Shenoy S., Chackalaparampil I., Bagrodia S., Lin P. H., Shalloway D. Role of p34cdc2-mediated phosphorylation in two-step activation of pp60c-src during mitosis. Proc. Natl. Acad. Sci. USA. 89:1992;7237-7241.
7. Xu W., Harrison S. C., Eck M. J. Three-dimensional structure of the tyrosine kinase c-Src. Nature. 385:1997;595-602.
8. Sicheri F., Moarefi I., Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 385:1997;602-609.
9. Williams J. C., Weijland A, Gonfloni S., Thompson A., Courtneidge S. A., Superti-Furga G., Wierenga R. K. The 2.35 A crystal structure of the inactivated form of chicken Src: A dynamic molecule with multiple regulatory interactions. J. Mol. Biol. 274:1997;757-775.
10. Mayer B. J. Signal transduction: Clamping down on Src activity. Curr. Biol. 7:1997;R295-R298.
11. Williams J. C., Wierenga R. K., Saraste M. Insights into Src kinase functions: Structural comparisons. Trends Biochem. Sci. 23:1998;179-184.
12. Hubbard S. R. Src autoinhibition: Let us count the ways. Nature Struct. Biol. 6:1999;711-714.
13. Imamoto A., Soriano P. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell. 73:1993;1117-1124.
14. Nada S., Yagi T., Takeda H., Tokunaga T., Nakagawa H., Ikawa Y., Okada M., Aizawa S. Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell. 73:1993;1125-1135.
15. Murphy S. M., Bergman M., Morgan D. O. Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: Analysis wtih Saccharomyces cerevisiae. Mol. Cell. Biol. 13:1993;5290-5300.
16. Okada M., Howell B. W., Broome M. A., Cooper J. A. Deletion of the SH3 domain of Src interferes with regulation by the phoshporylated carboxyl-terminal tyrosine. J. Biol Chem. 268:1993;18070-18075.
17. Superti-Furga G., Fumagalli S., Koegl M., Courtneidge S. A., Draetta G. Csk inhibtion of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J. 12:1993;2625-2634.
18. Erpel T., Superti-Furga G., Courtneidge S. A. Mutational analysis of the Src SH3 domain: The same residues of the ligand binding surface are important for intra- and intermolecular interactions. EMBO J. 14:1995;963-975.
19. Xu W., Doshi A., Lei M., Eck M. J., Harrison S. C. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol. Cell. 3:1999;629-638.
20. Schindler T., Sicheri F., Pico A., Gazit A., Levitzki A., Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol. Cell. 3:1999;639-648.
21. Gonfloni S., Williams J. C., Hattula K., Weijland A., Wierenga R. K., Superti-Furga G. The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src. EMBO J. 16:1997;7261-7271.
22. Moarefi I., LaFevre-Bernt M., Sicheri F., Huse M., Lee C. H., Kuriyan J., Miller W. T. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature. 385:1997;650-653.
23. Alexandropoulos K., Baltimore D. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin. Genes Dev. 10:1996;1341-1355.
24. Alonso G., Koegl M., Mazurenko N., Courtneidge S. A. Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J. Biol. Chem. 270:1995;9840-9848.
25. Irby R. B., Mao W., Coppola D., Kang J., Loubeau J. M., Trudeau W., Karl R., Fujita D. J., Jove R., Yeatman T. J. Activating SRC mutation in a subset of advanced human colon cancers. Nature Genet. 21:1999;187-190.
26. LaFevre-Bernt M., Sicheri F., Pico A., Porter M., Kuriyan J., Miller W. T. Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue. J. Biol. Chem. 273:1998;32129-32134.
27. Gonfloni S., Frischknecht F., Way M., Superti-Furga G. Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis. Nature Struct. Biol. 6:1999;760-764.
28. Briggs S. D., Smithgall T. E. SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in rat-2 fibroblasts. J. Biol. Chem. 274:1999;26579-26583.
29. Akhand A. A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M., Nakashima I. Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism. J. Biol. Chem. 274:1999;25821-25826.
30. Oda H., Kumar S., Howley P. M. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc. Natl. Acad. Sci. USA. 96:1999;9557-9562.
31. Brown M. T., Cooper J. A. Regulation, substrates and functions of src. Biochim. Biophys. Acta. 1287:1996;121-149.
32. Soriano P., Montgomery C., Geske R., Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 64:1991;693-702.
33. Lowell C. A., Soriano P. Knockouts of Src-family kinases: Stiff bones, wimpy T cells, and bad memories. Genes Dev. 10:1996;1845-1857.
34. Stein P. L., Vogel H., Soriano P. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 8:1994;1999-2007.
35. Klinghoffer R. A., Sachsenmaier C., Cooper J. A., Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:1999;2459-2471.
36. van der Geer P., Hunter T., Lindberg R. A. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:1994;251-337.
37. Ralston R., Bishop J. M. The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc. Natl. Acad. Sci. USA. 82:1985;7845-7849.
38. Gould K. L., Hunter T. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Mol. Cell. Biol. 8:1988;3345-3356.
39. Kypta R. M., Goldberg Y., Ulug E. T., Courtneidge S. A. Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell. 62:1990;481-492.
40. Mori S., Ronnstrand L., Yokote K., Engstrom A., Courtneidge S. A., Claesson-Welsh L., Heldin C. H. Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor: Involvement in the interaction with Src family tyrosine kinases. EMBO J. 12:1993;2257-2264.
41. Gelderloos J. A., Rosenkranz S., Bazenet C., Kazlauskas A. A role for Src in signal relay by the platelet-derived growth factor alpha receptor. J. Biol. Chem. 273:1998;5908-5915.
42. DeMali K. A., Kazlauskas A. Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol. Cell. Biol. 18:1998;2014-2022.
43. Stover D. R., Furet P., Lydon N. B. Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain. J. Biol. Chem. 271:1996;12481-12487.
44. Broome M. A., Hunter T. The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding. Oncogene. 14:1997;17-34.
45. Maa M. C., Leu T. H., McCarley D. J., Schatzman R. C., Parsons S. J. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers. Proc. Natl. Acad. Sci. USA. 92:1995;6981-6985.
46. Luttrell D. K., Luttrell L. M., Parsons S. J. Augmented mitogenic responsiveness to epidermal growth factor in Murine fibroblasts that overexpress pp60c-src. Mol. Cell. Biol. 8:1988;497-501.
47. Tice D. A., Biscardi J. S., Nickles A. L., Parsons S. J. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc. Natl. Acad. Sci. USA. 96:1999;1415-1420.
48. Weernink P. A., Rijksen G. Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factor. J. Biol. Chem. 270:1995;2264-2267.
49. Stover D. R., Becker M., Liebetanz J., Lydon N. B. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. J. Biol. Chem. 270:1995;15591-15597.
50. Sato K., Sato A., Aoto M., Fukami Y. Site-specific association of c-Src with epidermal growth factor receptor in A431 cells. Biochem. Biophys. Res. Commun. 210:1995;844-851.
51. Muthuswamy S. K., Muller W. J. Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. Oncogene. 11:1995;271-279.
52. Melillo R. M., Barone M. V., Lupoli G., Cirafici A. M., Carlomagno F., Visconti R., Matoskova B., Di Fiore P. P., Vecchio G., Fusco A., Santoro M. Ret-mediated mitogenesis requires Src kinase activity. Cancer Res. 59:1999;1120-1126.
53. Giancotti F. G., Ruoslahti E. Integrin signaling. Science. 285:1999;1028-1032.
54. Schlaepfer D. D., Hunter T. Integrin signaling and tyrosine phosphorylation: Just the FAKs. Trends Cell Biol. 8:1998;151-157.
55. Miyamoto S., Akiyama S. K., Yamada K. M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science. 267:1995;883-885.
56. Schaller M. D., Hildebrand J. D., Shannon J. D., Fox J. W., Vines R. R., Parsons J. T. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14:1994;1680-1688.
57. Miyamoto S., Teramoto H., Gutkind J. S., Yamada K. M. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135:1996;1633-1642.
58. Schneller M., Vuori K., Ruoslahti E. Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J. 16:1997;5600-5607.
59. Moro L., Venturino M., Bozzo C., Silengo L., Altruda F., Beguinot L., Tarone G., Defilippi P. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17:1998;6622-6632.
60. Wary K. K., Mariotti A., Zurzolo C., Giancotti F. G. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell. 94:1998;625-634.
61. Wei Y., Yang X., Liu Q., Wilkins J. A., Chapman H. A. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J. Cell Biol. 144:1999;1285-1294.
62. Mainiero F., Pepe A., Wary K. K., Spinardi L., Mohammadhi M., Schlessinger J., Giancotti F. G. Signal transduction by the alpha 6 beta 4 integrin; Distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14:1995;4470-4481.
63. Gutkind J. S. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J. Biol. Chem. 273:1998;1839-1842.
64. Hordijk P. L., Verlaan I., van Corven E. J., Moolenaar W. H. Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts: Evidence that phosphorylation of MAP kinase is mediated by the Gi-p21ras pathway. J. Biol. Chem. 269:1994;645-651.
65. Chen Y. H., Pouyssegur J., Courtneidge S. A., Van Obberghen-Schilling E. Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. J. Biol. Chem. 269:1994;27372-27377.
66. Daulhac L., Kowalski-Chauvel A., Pradayrol L., Vaysse N., Seva C. Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors. J. Biol. Chem. 274:1999;20657-20663.
67. Luttrell L. M., Hawes B. E., van Biesen T., Luttrell D. K., Lansing T. J., Lefkowitz R. J. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem. 271:1996;19443-19450.
68. Slack B. E. Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc. Natl. Acad. Sci. USA. 95:1998;7281-7286.
69. Luttrell L. M., Daaka Y., Della Rocca G. J., Lefkowitz R. J. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts: Shc phosphorylation and receptor endoctyosis correlate with activation of Erk kinases. J. Biol Chem. 272:1997;31648-31656.
70. Hanke J. H., Gardner J. P., Dow R. L., Changelian P. S., Brissette W. H., Weringer E. J., Pollok B. A., Connelly P. A. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:1996;695-701.
71. Daub H., Wallasch C., Lankenau A., Herrlich A., Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16:1997;7032-7044.
72. Della Rocca G. J., Maudsley S., Daaka Y., Lefkowitz R. J., Luttrell L. M. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade: Role of focal adhesions and receptor tyrosine kinases. J. Biol. Chem. 274:1999;13978-13984.
73. Blake R. A., Garcia-Paramio P., Parker P. J., Courtneidge S. A. Src promotes PKCdelta degradation. Cell Growth Differ. 10:1999;231-241.
74. Hawes B. E., van Biesen T., Koch W. J., Luttrell L. M., Lefkowitz R. J. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J. Biol. Chem. 270:1995;17148-17153.
75. Faure M., Voyno-Yasenetskaya T. A., Bourne H. R. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269:1994;7851-7854.
76. Nagao M., Kaziro Y., Itoh H. The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Galpha12. Oncogene. 18:1999;4425-4434.
77. Daub H., Weiss F. U., Wallasch C., Ullrich A. Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature. 379:1996;557-560.
78. Linseman D. A., Benjamin C. W., Jones D. A. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J. Biol. Chem. 270:1995;12563-12568.
79. Rao G. N., Delafontaine P., Runge M. S. Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells. J. Biol. Chem. 270:1995;27871-27875.
80. Cunnick J. M., Dorsey J. F., Standley T., Turkson J., Kraker A. J., Fry D. W., Jove R., Wu J. Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway. J. Biol. Chem. 273:1998;14468-14475.
81. Luttrell L. M., Della Rocca G. J., van Biesen T., Luttrell D. K., Lefkowitz R. J. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem. 272:1997;4637-4644.
82. Lopez-Ilasaca M., Crespo P., Pellici P. G., Gutkind J. S., Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science. 275:1997;394-397.
83. Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nurnberg B. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science. 269:1995;690-693.
84. Dikic I., Tokiwa G., Lev S., Courtneidge S. A., Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 383:1996;547-550.
85. Kurzchalia T. V., Parton R. G. Membrane microdomains and caveolae. Curr. Opin. Cell Biol. 11:1999;424-431.
86. Brown D. A., London E. Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14:1998;111-136.
87. Migliaccio A., Di Domenico M., Castoria G., de Falco A., Bontempo P., Nola E., Auricchio F. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15:1996;1292-1300.
88. Migliaccio A., Piccolo D., Castoria G., Di Domenico M., Bilancio A., Lombardi M., Gong W., Beato M., Auricchio F. Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J. 17:1998;2008-2018.
89. Castoria G., Barone M. V., Di Domenico M., Bilancio A., Ametrano D., Migliaccio A., Auricchio F. Non-transcriptional action of estradiol and progestin triggers DNA synthesis. EMBO J. 18:1999;2500-2510.
90. Twamley-Stein G. M., Pepperkok R., Ansorge W., Courtneidge S. A. The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA. 90:1993;7696-7700.
91. Roche S., Koegl M., Barone M. V., Roussel M. F., Courtneidge S. A. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases. Mol. Cell. Biol. 15:1995;1102-1109.
92. Broome M. A., Hunter T. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J. Biol. Chem. 271:1996;16798-16806.
93. Erpel T., Alonso G., Roche S., Courtneidge S. A. The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor. J. Biol. Chem. 271:1996;16807-16812.
94. Barone M. V., Courtneidge S. A. Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src. Nature. 378:1995;509-512.
95. Hansen K., Johnell M., Siegbahn A., Rorsman C., Engstrom U., Wernstedt C., Heldin C. H., Ronnstrand L. Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis. EMBO J. 15:1996;5299-5313.
96. Sato K., Sato A., Aoto M., Fukami Y. c-Src phosphorylates epidermal growth factor receptor on tyrosine 845. Biochem. Biophys. Res. Commun. 215:1995;1078-1087.
97. Biscardi J. S., Maa M. C., Tice D. A., Cox M. E., Leu T. H., Parsons S. J. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 274:1999;8335-8343.
98. Sachsenmaier C., Sadowski H. B., Cooper J. A. STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene. 18:1999;3583-3592.
99. Olayioye M. A., Beuvink I., Horsch K., Daly J. M., Hynes N. E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J. Biol. Chem. 274:1999;17209-17218.
100. Marshall C. J. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4:1994;82-89.
101. van der Geer P., Wiley S., Gish G. D., Pawson T. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. Curr. Biol. 6:1996;1435-1444.
102. Sato K., Gotoh N., Otsuki T., Kakumoto M., Aoto M., Tokmakov A. A., Shibuya M., Fukami Y. Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src. Biochem. Biophys. Res. Commun. 240:1997;399-404.
103. Buday L., Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell. 73:1993;611-620.
104. van Biesen T., Hawes B. E., Luttrell D. K., Krueger K. M., Touhara K., Porfiri E., Sakaue M., Luttrell L. M., Lefkowitz R. J. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signaling pathway. Nature. 376:1995;781-784.
105. Sadoshima J., Izumo S. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 15:1996;775-787.
106. Schieffer B., Paxton W. G., Chai Q., Marrero M. B., Bernstein K. E. Angiotensin II controls p21ras activity via pp60c-src. J. Biol. Chem. 271:1996;10329-10333.
107. Schlaepfer D. D., Hanks S. K., Hunter T., van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 372:1994;786-791.
108. Schlaepfer D. D., Jones K. C., Hunter T. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol. 18:1998;2571-2585.
109. Vieira A. V., Lamaze C., Schmid S. L. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science. 274:1996;2086-2089.
110. Ware M. F., Tice D. A., Parsons S. J., Lauffenburger D. A. Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor. J. Biol. Chem. 272:1997;30185-30190.
111. Wilde A., Beattie E. C., Lem L., Riethof D. A., Liu S. H., Mobley W. C., Soriano P., Brodsky F. M. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 96:1999;677-687.
112. Ferguson S. S., Downey W. E. 3rd, Colapietro A. M., Barak L. S., Menard L., Caron M. G. Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science. 271:1996;363-366.
113. Daaka Y., Luttrell L. M., Ahn S., Della Rocca G. J., Ferguson S. S., Caron M. G., Lefkowitz R. J. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J. Biol. Chem. 273:1998;685-688.
114. Luttrell L. M., Ferguson S. S., Daaka Y., Miller W. E., Maudsley S., Della Rocca G. J., Lin F., Kawakatsu H., Owada K., Luttrell D. K., Caron M. G., Lefkowitz R. J. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 283:1999;655-661.
115. Ahn S., Maudsley S., Luttrell L. M., Lefkowitz R. J., Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J. Biol. Chem. 274:1999;1185-1188.
116. Van Aelst L., D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 11:1997;2295-2322.
117. Hall A. Rho GTPases and the actin cytoskeleton. Science. 279:1998;509-514.
118. Tarone G., Cirillo D., Giancotti F. G., Comoglio P. M., Marchisio P. C. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp. Cell Res. 159:1985;141-157.
119. Gavazzi I., Nermut M. V., Marchisio P. C. Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells. J. Cell Sci. 94:1989;85-99.
120. Fincham V. J., Unlu M., Brunton V. G., Pitts J. D., Wyke J. A., Frame M. C. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol. 135:1996;1551-1564.
121. Fincham V. J., Frame M. C. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17:1998;81-92.
122. Okamura H., Resh M. D. Differential binding of pp60c-src and pp60v-src to the cytoskeleton is mediated by SH2 and catalytic domains. Oncogene. 9:1994;2293-2303.
123. Ridley A. J., Hall A. Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase. EMBO J. 13:1994;2600-2610.
124. Flinn H. M., Ridley A. J. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J. Cell Sci. 109:1996;1133-1141.
125. Nobes C. D., Hawkins P., Stephens L., Hall A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J.Cell Sci. 108:1995;225-233.
126. Crespo P., Schuebel K. E., Ostrom A. A., Gutkind J. S., Bustelo X. R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 385:1997;169-172.
127. Schuebel K. E., Movilla N., Rosa J. L., Bustelo X. R. Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17:1998;6608-6621.
128. Roof R. W., Haskell M. D., Dukes B. D., Sherman N., Kinter M., Parsons S. J. Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Mol. Cell. Biol. 18:1998;7052-7063.
129. Fincham V. J., Chudleigh A., Frame M. C. Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci. 112:1999;947-956.
130. Mayer T., Meyer M., Janning A., Schiedel A. C., Barnekow A. A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts. Oncogene. 18:1999;2117-2128.
131. Tapon N., Nagata K., Lamarche N., Hall A. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signaling pathways. EMBO J. 17:1998;1395-1404.
132. Aspenstrom P. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. Curr. Biol. 7:1997;479-487.
133. Sotiropoulos A., Gineitis D., Copeland J., Treisman R. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell. 98:1999;159-169.
134. Lock P., Abram C. L., Gibson T., Courtneidge S. A. A new method for isolating tyrosine kinase substrates used to identify Fish, an SH3 and PX domain-containing protein, and Src substrate. EMBO J. 17:1998;4346-4357.
135. Huang C., Ni Y., Wang T., Gao Y., Haudenschild C. C., Zhan X. Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. J. Biol. Chem. 272:1997;13911-13915.
136. Kaplan K. B., Swedlow J. R., Morgan D. O., Varmus H. E. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 9:1995;1505-1517.
137. Schlaepfer D. D., Broome M. A., Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol. Cell. Biol. 17:1997;1702-1713.
138. Ilic D., Furuta Y., Kanazawa S., Takeda N., Sobue K., Nakatsuji N., Nomura S., Fujimoto J., Okada M., Yamamoto T. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 377:1995;539-544.
139. Honda H., Oda H., Nakamoto T., Honda Z., Sakai R., Suzuki T., Saito T., Nakamura K., Nakao K., Ishikawa T., Katsuki M., Yazaki Y., Hirai H. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nature Genet. 19:1998;361-365.
140. Brown M. T., Andrade J., Radhakrishna H., Donaldson J. G., Cooper J. A., Randazzo P. A. ASAP1, a phospholipid-dependent Arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol. Cell. Biol. 18:1998;7038-7051.
141. Klemke R. L., Cai S., Giannini A. L., Gallagher P. J., de Lanerolle P., Cheresh D. A. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137:1997;481-492.