A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

Current Biology

Volumn 7, Issue 7, 1997, Pages 479-487

  Aspenström, Pontus ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031194076     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(06)00219-3     Document Type: Article

References (54)

1. Bretscher A: Microfilament structure and function in the cortical cytoskeleton. Annu Rev Cell Biol 1991, 7:337-374.
2. Mitchison TJ, Cramer LP: Actin-based cell motility and cell locomotion. Cell 1996, 84:371-379.
3. Mellström K, Höglund A-S, Nistér M, Heldin C-H, Westermark B, Lindberg U: The effect of platelet derived growth factor on morphology and motility of human glial cells. J Muscle Res Cell Motil 1983, 4:589-609.
4. Chinkers M, McKanna JA, Cohen S: Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol 1979, 83:260-265.
5. Hall A: Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 1994, 10:31-54.
6. Foster R, Hu K-Q, Lu Y, Nolan KM, Thissen J, Settleman J: Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol 1996, 16:2689-2699.
7. Cerione RA, Zheng Y: Dbl family of oncogenes. Curr Opin Cell Biol 1996, 8:216-222.
8. Lamarche N, Hall A: GAPs for Rho-related GTPases. Trends Genet 1994, 10:436-440.
9. Ridley AJ, Paterson HF, Johnston CL, Diekman D, Hall A: The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 1992, 70:401-410.
10. Ridley AJ, Hall A: The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70:389-399.
11. Johnson DI, Pringle JR: Molecular characterization of Cdc42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 1990, 111:143-152.
12. Nobes CD, Hall A: Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lammelipodia and filopodia. Cell 1995, 81:53-62.
13. Kozma R, Ahmed S, Best A, Lim L: The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol 1995, 15:1942-1952.
14. Coso OA, Chiariello M, Yu J-C, Teramoto H, Crespo P, Xu N, et al.: The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995, 81:1137-1146.
15. Minden A, Lin A, Claret F-X, Abo A, Karin M: Selective activation of the JNK signalling cascade and c-Jun transcriptional activity by the small GTPases rac and Cdc42Hs. Cell 1995, 81:1147-1157.
16. Hill CS, Wynne J, Triesman R: The Rho GTPases RhoA, Rac1 and Cdc42Hs regulate transcriptional activation by SRF. Cell 1995, 81:1159-1170.
17. 1. Science 1995, 269:1270-1272.
18. Qui R-G, Chen J, Kirn D, McCormick F, Symons M: An essential role for Rac in Ras transformation. Nature 1995, 374:457-459.
19. Qui R-G, Chen J, McCormick F, Symons M: A role for Rho in Ras transformation. Proc Natl Acad Sci USA 1995, 92:11781-11785.
20. Khosravi-Far R, Solkski PA, Clark GJ, Kinch MS, Der CJ: Activation of Rac1, RhoA and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 1995, 15:6443-6453.
21. Manser E, Leung T, Salihuddin Zhao ZS, Lim L: A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994, 367:40-46.
22. Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ: Identification and characterisation of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J Biol Chem 1994, 269:15092-15100.
23. Ing LY, Leung IWL, Heng HQH, Tsui L-C, Lassam NJ: MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. Oncogene 1994, 9:1745-1750.
24. cdc42. Nature 1993, 263:364-367.
25. Aspenström P, Lindberg U, Hall A: Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol 1996, 6:70-75.
26. Symons M, Derry JMJ, Karlak B, Jiang S, Lemahieu V, McCormick F, et al.: Wiskott-Aldrich syndrome protein, a novel effector for the GTPase Cdc42, is implicated in actin polymerization. Cell 1996, 84:723-734.
27. Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T: Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci 1996, 93:5615-5618.
28. Burbelo PD, Drechsel D, Hall A: A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 1995, 270:29071-29074.
29. Hart MJ, Callow MG, Souza B, Polakis P: IQGAP1, a calmodulin-binding protein with a RasGAP-related domain, is a potential effector for Cdc42Hs. EMBO J 1996, 15:2997-3005.
30. Chou MM, Blenis J: The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 1996, 85:573-583.
31. PAK and the JNK/SAPK MAP kinase cascade. Cell 1996, 87:519-529.
32. Joneson T, McDonough M, Bar-Sagi D, Van Aelst L: RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 1996, 274:1374-1376.
33. Aitken A: 14-3-3 proteins on the MAP. Trends Biochem Sci 1995, 20:95-97.
34. Lee JW, Choi H-S, Gyuris J, Brent R, Moore DD: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol 1995, 9:243-254.
35. Kozak M: Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Biol Chem 1991, 266:19867-19870.
36. Chan DC, Bedford MT, Leder P: Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J 1996, 15:1045-1054.
37. Hao G-L, Heisterkamp N, Groffen J: Isolation and sequence analysis of a novel human tyrosine kinase gene. Mol Cell Biol 1989, 9:1587-1593.
38. Sadowski I, Stone JC, Pawson T: An noncatalytical domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami Sarcoma virus p130gag-fps. Mol Cell Biol 1986, 6:4396-4408.
39. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, et al.: An X chromosome-linked gene encoding a protein with characteristics of a RhoGAP predominantly expressed in hematopoietic cells. Proc Natl Acad Sci USA 1996, 93:695-699.
40. Frankhauser C, Reymond A, Cerutti L, Utzig S, Hofmann K, Simanis V: The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Cell 1995, 82:435-444.
41. Arpin M, Algrain M, Louvard D: Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1. Curr Opin Cell Biol 1994, 6:136-141.
42. Aspenström P, Olson MF: Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases. Meth Enzymol 1995, 256:228-241.
43. Small JV: The actin cytoskeleton. Electron Microscop Rev 1988, 1:155-174.
44. Brown JL, Stowers L, Baer M, Trejo JA, Coughlin S, Chant J: Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol 1996, 6:598-605.
45. Frost JA, Xu S, Hutchinson MR, Marcus S, Cobb MH: Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol 1996, 16:3707-3713.
46. Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS: Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. J Biol Chem 1996, 271:27225-27228.
47. Tibbles LA, Ing YL, Kiefer F, Chan J, Iscove N, Woodgett JR, Lassam NJ: MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J 1996, 15:7026-7035.
48. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM Chernoff J: Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 1997, 7:202-210.
49. Pasteris NG, Cadle A, Logie LJ, Porteous MEM, Schwartz CE, Stevenson RE, et al.: Isolation and characterization of the Faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor. Cell 1994, 79:669-678.
50. Olson MF, Pasteris NG, Gorski JL, Hall A: Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryogenetic development, are upstream regulators of Rho GTPases. Curr Biol 1996, 6:1628-1633.
51. Turunen O, Whalström T, Vaheri A: Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol 1994, 126:1445-1453.
52. Pestonjamasp K, Amieva MR, Strassel CP, Nauseef WM, Furthmayr H, Luna EJ: Moesin, ezrin and p205 are actin-binding proteins associated with neutrophil plasma membranes. Mol Biol Cell 1995. 6:247-259.
53. Berryman M, Franck Z, Bretscher A: Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. J Cell Sci 1993, 105:1025-1043,
54. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: a Laboratory Manual, 2nd edn. Plainview, New York: Cold Spring Harbor Laboratory press; 1989.