Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.

Journal of medicinal chemistry

Volumn 41, Issue 11, 1998, Pages 1741-1744

  Garcia Echeverria C ^a   Furet, P ^a   Gay, B ^a   Fretz, H ^a   Rahuel, J ^a   Schoepfer, J ^a   Caravatti, G ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO PHENYLMETHOXYCARBONYL PHOSPHOTYROSYL 1 AMINOCYCLOHEXANECARBONYL ASPARAGINAMIDE; 3-AMINO-PHENYLMETHOXYCARBONYL-PHOSPHOTYROSYL-1-AMINOCYCLOHEXANECARBONYL-ASPARAGINAMIDE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LIGAND; OLIGOPEPTIDE; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HYDROGEN BOND; METABOLISM; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GRB2 ADAPTOR PROTEIN; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEINS; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

MLCS; MLOWN;

EID: 0032554740     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970856n     Document Type: Article

References (0)