Actinomycin D as a novel SH2 domain ligand inhibits Shc/Grb2 interaction in b104-1-1 (neu*-transformed NIH3T3) and SAA (hEGFR-overexpressed NIH3T3) cells

FEBS Letters

Volumn 453, Issue 1-2, 1999, Pages 174-178

  Kim, Hyae Kyeong ^a   Nam, Ji Youn ^a   Han, Mi Young ^a   Lee, Eun Kyung ^a   Choi, Jung Do ^b   Bok, Song Hae ^a   Kwon, Byoung Mog ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Actinomycin; Cyclopeptide antibiotic; Extracellular signal regulated protein kinase; Grb2; Shc; Src homology 2 domain

Indexed keywords

DACTINOMYCIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; POLYCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CELL LYSATE; COMPLEX FORMATION; GROWTH INHIBITION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANTI-BACTERIAL AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DACTINOMYCIN; GRB2 ADAPTOR PROTEIN; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFORMATION, GENETIC;

EID: 0032768320     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)00710-3     Document Type: Article

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