Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding

Journal of Biological Chemistry

Volumn 273, Issue 32, 1998, Pages 20238-20242

  Tong, Liang ^a,b   Warren, Thomas C ^a   Lukas, Susan ^a   Schembri King, Josephine ^a   Betageri, Raj ^a   Proudfoot, John R ^a   Jakes, Scott ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYMETHYLPHENYLALANINE; INHIBITOR PROTEIN; PHENYLALANINE DERIVATIVE; PHOSPHOTYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHENYLALANINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAINS;

EID: 0032493756     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.32.20238     Document Type: Article

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