Granzymes (lymphocyte serine proteases): Characterization with natural and synthetic substrates and inhibitors

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1477, Issue 1-2, 2000, Pages 307-323

  Kam, Chih Min ^a   Hudig, Dorothy ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxic lymphocyte; Granzyme; Inhibitor; Molecular modeling; Serine protease; Substrate specificity

Indexed keywords

ENZYME INHIBITOR; GRANZYME A; GRANZYME B; ISOCOUMARIN DERIVATIVE; LYMPHOCYTE SERINE PROTEINASE; PERFORIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

CYTOTOXIC LYMPHOCYTE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; BINDING SITES; CHYMASES; CYTOPLASMIC GRANULES; DEOXYRIBONUCLEASES; ENZYME ACTIVATION; GRANZYMES; HUMANS; KILLER CELLS; KINETICS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC; TRYPTASES;

EID: 0034615553     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00282-4     Document Type: Review

References (123)

1. Hameed A., Schafer R.W., Sundaresan V.D., Vaccarello L. Hum. Immunol. 49:1996;13-21.
2. Atkinson E.A., Bleakley R.C. Crit. Rev. Immunol. 15:1995;359-384.
3. P.A. Henkart, M.S. Williams, H. Nakajima, in: P.A. Henkart, M.S. Williams, H. Nakajima (Eds.), Pathway for Cytolysis, Springer-Verlag, Berlin, 1995, pp. 75-94.
4. Tschopp J., Jongeneel V. Biochemistry. 27:1988;2641-2646.
5. Smyth M.J., Trapani J.A. Immunol. Today. 16:1995;202-206.
6. Trapani J.A. Aust. New Zealand J. Med. 25:1995;793-799.
7. Nagata S., Golstein P. Science. 267:1995;1449-1456.
8. Shinkai Y., Takio K., Okumura K. Nature. 334:1988;525-527.
9. Podack E.R. Curr. Top. Microbiol. Immunol. 178:1992;175-184.
10. Yagita H., Nagata M., Kawasaki A., Shinkai Y., Okumura K. Adv. Immunol. 51:1992;215-242.
11. Russell J.H. Immunol. Rev. 72:1983;97-117.
12. Duke R.C., Chervenak R., Cohen J.J. Proc. Natl. Acad. Sci. USA. 80:1983;6361-6365.
13. Redelman D., Hudig D. J. Immunol. 124:1980;870-878.
14. Chang T.W., Eisen H.E. Nature. 124:1980;1028-1033.
15. Hudig D., Gregg N.J., Kam C.-M., Powers J.C. Biochem. Biophys. Res. Commun. 149:1987;882-888.
16. Hudig D., Allison N.J., Pickett T.M., Winkler U., Kam C.-M., Powers J.C. J. Immunol. 147:1991;1360-1368.
17. Shi L., Kam C., Powers J.C., Aebersold R., Greenberg A.H. J. Exp. Med. 176:1992;1521-1529.
18. Hayes M.P., Berrebi G.A., Henkart P.A. J. Exp. Med. 170:1989;933-946.
19. Shiver J.W., Su L., Henkart P.A. Cell. 71:1992;315-322.
20. Shi L., Kraut R.P., Aebersold R., Greenberg A.H. J. Exp. Med. 175:1992;553-566.
21. Heusel J.W., Wesselschmidt R.L., Shresta S., Russel J.H., Ley T.J. Cell. 76:1994;977-987.
22. Darmon A.J., Nicholson D.W., Bleackley R.C. Nature. 377:1995;446-448.
23. Martin S.J., Amarante-Mendes G.P., Shi L., Chuang T.-H., Casiano C.A., O'Brian G.A., Fitzgerald P., Tan E.M., Bokoch G.M., Greenberg A.H., Green D.R. EMBO J. 15:1996;2407-2416.
24. Fernandes-Alnemri T., Armstrong R., Krebs J., Srinivasula S.M., Wang L., Bullrich F., Fritz L.C., Trapani J.A., Tomaselli K.J., Litwack G., Alnemri E.S. Proc. Natl. Sci. USA. 93:1996;7464-7469.
25. Trapani J.A., Browne K.A., Smyth M.J., Jans D.A. J. Biol. Chem. 271:1996;4127-4133.
26. Woodard S.L., Fraser S.A., Winkler U., Jackson D.S., Kam C.-M., Powers J.C., Hudig D. J. Immunol. 160:1998;4988-4993.
27. Masson D., Tschopp J. Cell. 49:1987;679-685.
28. Hanna W.L., Turbov J.M., Jackman H.L., Tan F., Froelich C.J. J. Immunol. 153:1994;4663-4672.
29. Haddad P., Jenne D., Tschopp J., Clement M.V., Mathieu-Mahul D., Sasportes M. Int. Immunol. 3:1991;57-66.
30. Griffiths G.M., Isaaz S. J. Cell Biol. 120:1993;885-896.
31. Salvesen G., Enghild J.J. Biochemistry. 29:1990;5304-5308.
32. Smyth M.J., Sayers T.J., Wiltrout T., Powers J.C., Trapani J.A. J. Immunol. 151:1993;6195-6205.
33. Kelly J.M., O'Connor M.D., Hulett M.D., Thia K.Y., Smyth M.J. Immunogenetics. 44:1996;340-350.
34. Prendergast J.A., Helgason C.D., Bleackley R.C. J. Biol. Chem. 267:1992;5090-5095.
35. Odake S., Kam C.-M., Narasimhan L., Poe M., Blake J.T., Krahenbuhl O., Tschopp J., Powers J.C. Biochemistry. 30:1991;2217-2227.
36. Fruth U., Siningaglia F., Schlesier M., Kilgus J., Kramer M.D., Simon M.M. Eur. J. Immunol. 17:1987;1625-1633.
37. Poe M., Bennett C.D., Biddison W.E., Blake J.T., Norton G.P., Rodkey J.A., Sigal N.H., Turner R.V., Wu J.K., Zweerink H.J. J. Biol. Chem. 263:1988;13215-13222.
38. Poe M., Blake J.T., Boulton D.A., Gammon M., Sigal N.H., Wu J.K., Zweerink H.J. J. Biol. Chem. 266:1991;98-103.
39. Kramer M.D., Binninger L., Schirrmacher V., Moll H., Prester M., Nerz G., Simon M.M. J. Immunol. 136:1986;4644-4651.
40. Sayers T.J., Wiltrout T.A., Smyth M.J., Ottaway K.J., Pilaro A.M., Sowder R., Henderson L.E., Sprenger H., Lloyd A.R. J. Immunol. 152:1994;2289-2297.
41. Smyth M.J., Wiltrout T., Trapani J.A., Ottaway K.S., Sowder R., Henderson L.E., Kam C., Powers J.C., Young H.A., Sayers T.J. J. Biol. Chem. 267:1992;24418-24425.
42. Sayers T.J., Lloyd A.R., McVicar D.W., O'Connor M.D., Kelly J.M., Carter C.R.D., Wiltrout T.A., Wiltrout R.H., Smyth M.J. J. Leukocyte Biol. 59:1996;763-768.
43. Hanson R.D., Hohn P.A., Popescu N.C., Ley T.J. Proc. Natl. Acad. Sci. USA. 87:1990;960-963.
44. Klein J.L., Selvakumar A., Trapani J.A., Dupont B. Tissue Antigens. 35:1990;220-228.
45. Amerik A.Y., Yarovoi S.V., Grigorenko V.G., Antonov V.K. FEBS Lett. 324:1993;226-230.
46. Grigorenko V.G., Yarovoi S.V., Paulauskaite R., Amerik A.Y. FEBS Lett. 342:1994;278-280.
47. Ewoldt G.R., Hudig D., Darcy P.K., Harris J.L., Craik C.S., Smyth M.J. Immunogenetics. 45:1997;452-454.
48. Perona J.J., Craik C.S. Protein Sci. 4:1995;337-360.
49. Murphy M.E.P., Moult J., Bleackley R.C., Gershenfeld H., Weissman I.L., James M.N.G. Proteins Struct. Funct. Genet. 4:1988;190-204.
50. Caputo A., James M.N.G., Powers J.C., Hudig D., Bleackley R.C. Struct. Biol. 1:1994;364-367.
51. Harris J.L., Peterson E.P., Hudig D., Thornberry N.A., Craik C.S. J. Biol. Chem. 273:1998;27364-27373.
52. Smyth M.J., O'Connor M.D., Trapani J.A., Kershaw M.H., Brinkworth R.I. J. Immunol. 156:1996;4174-4181.
53. Ewoldt G.R., Smyth M.J., Darcy P.K., Harris J.L., Craik C.S., Horowitz B., Woodard S.L., Powers J.C., Hudig D. J. Immunol. 158:1997;4574-4583.
54. Powers J.C., Kam C.M. Methods Enzymol. 248:1995;3-18.
55. McRae B.J., Kurachi K., Heimark R.L., Fujikawa K., Davie E.W., Powers J.C. Biochemistry. 20:1981;7196-7206.
56. Kam C.-M., Vlasuk G.P., Smith D.E., Arcuri K.E., Powers J.C. Thromb. Haemost. 64:1990;133-137.
57. Kam C.-M., McRae B.J., Harper J.W., Niemann M.A., Volanakis J.E., Powers J.C. J. Biol. Chem. 262:1987;3444-3451.
58. Grassetti D.R., Murray J.F. Jr. Arch. Biochem. Biophys. 119:1967;41-49.
59. Farmer D.A., Hageman J.H. J. Biol. Chem. 250:1975;7366-7371.
60. Powers J.C., Tanaka T., Harper J.W., Minematsu Y., Barker L., Lincoln D., Crumley K.V., Fraki J.E., Schechter N.M., Lazarus G.G., Nakajima K., Nakashino K., Neurath H., Woodbury R.G. Biochemistry. 24:1985;2048-2058.
61. Ashe B.M., Zimmerman M. J. Appl. Biochem. 2:1980;445-447.
62. Hudig D., Gregg N.J., Kam C.-M., Powers J.C. Biochem. Biophys. Res. Commun. 149:1987;882-888.
63. Beresford P.J., Kam C.-M., Powers J.C., Lieberman J. Proc. Natl. Acad. Sci. USA. 94:1997;9285-9290.
64. Talanian R.V., Yang X.H., Turbov J., Seth P., Ghayur T., Casiano C.A., Orth K., Froelich C.J. J. Exp. Med. 186:1997;1323-1331.
65. Xia Z., Kam C.-M., Huang C., Powers J.C., Mandle R.J., Stevens R.L., Lieberman J. Biochem. Biophys. Res. Commun. 243:1998;384-389.
66. Babe L.M., Yoast S., Dreyer M., Schmidt B.F. Biotechnol. Appl. Biochem. 27:1998;117-124.
67. Irmler M., Hertig S., MacDonald H.R., Sadoul R., Becherer J.D., Proudfoot A., Solari R., Tschopp J. J. Exp. Med. 181:1995;1917-1922.
68. Suidan H.S., Bouvier J., Schaerer E., Stone S.R., Monard D., Tschopp J. Proc. Natl. Acad. Sci. USA. 91:1994;8112-8116.
69. Suidan H.S., Clemetson K.J., Brown-Luedi M., Niclou S.P., Clemetson J.M., Tschopp J., Monard D. Biochem. J. 315:1996;939-945.
70. Sower L.E., Froelich C.J., Allegretto N., Rose P.M., Hanna W.D., Klimpel G.R. J. Immunol. 156:1996;2585-2590.
71. Simon M.M., Kramer M.D., Prester M., Gay S. Immunology. 73:1991;117-119.
72. Vanguri P., Lee E., Henkart P.A., Shin M.L. J. Immunol. 150:1993;2431-2439.
73. Vettel U., Bar-Shavit R., Simon M.M., Brunner G., Vlodavsky I., Kramer M.D. Eur. J. Immunol. 21:1991;2247-2251.
74. Nakamura K., Arahata K., Ishiura S., Osame M., Sugita H. Neuromuscul. Disord. 3:1993;303-310.
75. Mullbacher A., Ebnet K., Blanden R.V., Hla R.T., Stehle T., Museteanu C., Simmon M.M. Proc. Natl. Acad. Sci. USA. 93:1996;5783-5787.
76. Lincz L.F. Immunol. Cell Biol. 76:1998;1-19.
77. Sarin A., Williams M.S., Alexander-Miller M.A., Berzofsky J.A., Zacharchuk C.M., Henkart P.A. Immunity. 6:1997;209-215.
78. Andrade F., Roy S., Nicholson D., Thornberry N., Rosen A., Casciola-Rosen L. Immunity. 8:1998;451-460.
79. Quan L.T., Tewari M., O'Rourke K., Dixit V., Snipas S.J., Poirier G.G., Ray C., Pickup D.J., Salvensen G.S. Proc. Natl. Acad. Sci. USA. 93:1996;1972-1976.
80. Orth K., Chinnaiyan A.M., Garg M., Froelich C.J., Dixit V.M. J. Biol. Chem. 271:1996;16443-16446.
81. Chinnaiyan A.M., Orth K., Hanna W.L., Duan H.J., Poirier G.G., Froelich C.J., Dixit V.M. Curr. Biol. 6:1996;897-899.
82. Gu Y., Sarnecki C., Fleming M.A., Lippke J.A., Bleackley R.C., Su M.S.S. J. Biol. Chem. 271:1996;10816-10820.
83. Zhou Q., Salvesen G.S. Biochem. J. 324:1997;361-364.
84. Medema J.P., Toes R.E.M., Scaffidi C., Zheng T.S., Flavell R.A., Melief C.J.M., Peter M.E., Offringa R., Krammer P.H. Eur. J. Immunol. 27:1997;3492-3498.
85. Duan H., Chinnaiyan O.K.A.M., Poirier G.G., Froelich C.J., He W.-W., Dixit V.M. J. Biol. Chem. 271:1996;16720-16724.
86. Vincenz C., Dixit V.M. J. Biol. Chem. 272:1997;6578-6583.
87. Darmon A.J., Ley T.J., Nicholson D.W., Bleackley R.C. J. Biol. Chem. 271:1996;21709-21712.
88. Froelich C.J., Janna W.L., Poirier G.G., Duriez P.J., D'Amours D., Salvesen G.S., Alnemri E.S., Earnshaw W.C., Shah G.M. Biochem. Biophys. Res. Commun. 227:1996;658-665.
89. Galvin J.P., Spaeny-Dekking L.H., Wang B., Seth P., Hack C.E., Froelich C.J. J. Immunol. 162:1999;5345-5350.
90. Froelich C.J., Zhang X., Turbov J., Hudig D., Winkler U., Hanna W.L. J. Immunol. 151:1993;7161-7171.
91. Sayers T.J., Wiltrout T.A., Sowder R., Munger W.L., Smyth M.J., Henderson L.E. J. Immunol. 148:1992;292-300.
92. J.C. Powers, J.W. Harper, in: Proteinase Inhibitors A.J. Barrett, G. Salvensen (Eds.), Elsevier, Amsterdam, 1985, pp. 55-152.
93. Jansen E.J., Nutting M.D.F., Jang R., Ball A.K. J. Biol. Chem. 179:1949;189-199.
94. Fahrney D.E., Gold A. J. Am. Chem Soc. 85:1963;997-1000.
95. Harper J.W., Hemmi K., Powers J.C. Biochemistry. 24:1985;1831-1841.
96. Jackson D.S., Fraser S.A., Ni L.-M., Kam C.-M., Winkler U., Johnson D.A., Froelich C.J., Hudig D., Powers J.C. J. Med. Chem. 41:1998;2289-2301.
97. Poe M., Wu J.K., Blake J.T., Zweerink H.J., Sigal N.H. Arch. Biochem. Biophys. 284:1991;215-218.
98. Powers J.C., Kam C.-M. Methods Enzymol. 247:1995;442-457.
99. Harper J.W., Powers J.C. Biochemistry. 24:1985;7200-7213.
100. Schoellmann G., Shaw E. Biochemistry. 2:1963;252-255.
101. Shaw E., Mares-Guia M., Cohen W. Biochemistry. 4:1965;2219-2223.
102. Simon M.M., Fruth U., Simon H.G., Kramer M.D. Ann. Inst. Pasteur. 138:1987;309-314.
103. Oleksyszyn J., Powers J.C. Biochemistry. 30:1991;485-493.
104. Oleksyszyn J., Powers J.C. Methods Enzymol. 244:1994;423-441.
105. Woodard S.L., Jackson D.S., Abuelyaman A.S., Powers J.C., Winkler U., Hudig D. J. Immunol. 153:1994;5016-5025.
106. Hudig D., Allison N.J., Kam C.-M., Powers J.C. Mol. Immunol. 26:1989;793-798.
107. Ewoldt G.R., Winkler U., Powers J.C., Hudig D. Mol. Immunol. 29:1992;713-721.
108. Potempa J., Korzus E., Travis J. J. Biol. Chem. 269:1994;15957-15960.
109. Bird P.I. Immunol. Cell Biol. 77:1999;47-57.
110. Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., De Jong T.A., Trapani J.A., Bird P.I. J. Biol. Chem. 271:1996;27802-27809.
111. Quan L.T., Caputo A., Bleackley R.C., Pickup D.J., Salvesen G.S. J. Biol. Chem. 270:1995;10377-10379.
112. Sun J., Ooms L., Bird C.H., Sutton V.R., Trapani J.A., Bird P.I. J. Biol. Chem. 272:1997;15434-15441.
113. Hill R.M., Morresey K.S., Coates L.C., Mezey E., Fell B., Bratt T., Trapani J.A., Birch N.P. FEBS Lett. 440:1998;361-364.
114. Schecter I., Berger A. Biochem. Biophys. Res. Commun. 27:1967;157-162.
115. Hudig D., Ewoldt G.R., Woodard S.L. Curr. Opin. Immunol. 5:1993;90-96.
116. Pasternack M.S., Bleier K.J., McInerney T.N. J. Biol. Chem. 266:1991;14703-14708.
117. Simon M.M., Prester M., Nerz G., Kramer M.D., Fruth U. Biol. Chem. Hoppe Seyer. 369:1988;107-112.
118. Brunner G., Simon M.M., Kramer M.D. FEBS Lett. 260:1990;141-144.
119. Stennicke H.R., Jurgensmeier J.M., Shin H., Deveraux Q., Wolf B.B., Yang X., Zhou Q., Ellerby H.M., Ellerby L.M., Bredesen D., Green D.R., Reed J.C., Froelich C.J., Salvesen G.S. J. Biol. Chem. 273:1998;27084-27090.
120. Masson D., Tschopp J. Mol. Immunol. 25:1988;1283-1289.
121. Wagner L., Avery R.L., Bensinger L., Kusinitz F., Hibberd P.L., Pasternack M.S. Mol. Immunol. 32:1995;853-864.
122. McGrath M.E., Gillmor S.A., Fletterick R.J. Protein Sci. 4:1995;141-148.
123. Edwards K.M., Kam C.-M., Powers J.C., Trapani J.A. J. Biol. Chem. 237:1999;30468-30473.