Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2289-2301

  Jackson, Delwin S ^a   Fraser, Stephanie A ^b   Ni, Li Ming ^a   Kam, Chih Min ^a   Winkler, Ulrike ^b   Johnson, David A ^d   Froelich, Christopher J ^c   Hudig, Dorothy ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYL N (N BENZYLOXYCARBONBNYLALANYL)AMINO (4 AMIDINOPHENYL)METHANEPHOSPHONATE; DIPHENYL N (N BENZYLOXYCARBONYLALANYLALANYLALANYL)AMINO (4 AMIDINOPHENYL)METHANEPHOSPHONATE; DIPHENYL N (N SUCCINYLALANYLALANYL)AMINO (4 AMIDINOPHENYL)METHANEPHOSPHONATE; ENZYME INHIBITOR; GRANZYME A; GRANZYME A INHIBITOR; GRANZYME K INHIBITOR; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; IMMUNOMODULATION; MAST CELL; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; CATTLE; CHYMASES; GRANZYMES; HUMANS; KINETICS; MAST CELLS; OLIGOPEPTIDES; PHOSPHONIC ACIDS; RATS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES, CYTOTOXIC; TRYPSIN; TRYPSIN INHIBITORS; TRYPTASES;

EID: 0032543521     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970543s     Document Type: Article

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