Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3

Journal of Leukocyte Biology

Volumn 59, Issue 5, 1996, Pages 763-768

  Sayers, Thomas J ^a   Lloyd, Andrew R ^c   McVicar, Daniel W ^b   O'Connor, Michael D ^d   Kelly, Janice M ^d   Carter, Clive R D ^b   Wiltrout, Theresa A ^a   Wiltrout, Robert H ^b   Smyth, Mark J ^d  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PRINCE HENRY HOSPITAL   (Australia)

^d AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

cDNA; serine protease; T cells

Indexed keywords

TRYPTASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL GRANULE; CELL MEDIATED CYTOTOXICITY; CYTOTOXIC T LYMPHOCYTE; DNA LIBRARY; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KILLER CELL; MOLECULAR CLONING; PRIORITY JOURNAL;

EID: 0029937520     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.5.763     Document Type: Article

References (31)

1. Masson, D., Tschopp, J. (1987) A family of serine esterases in the lytic granules of cytotoxic T lymphocytes. Cell 49, 679-685.
2. Jenne, D. E., Tschopp, J. (1988) Granzymes, a family of serine proteases released from the granules of cytolytic T lymphocytes upon T cell receptor stimulation. Immunol.Rev. 103, 53-71.
3. Podack, E. R., Young, J. D-E., Cohn, Z. A. (1985) Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc. Natl. Acad. Sci. USA. 82, 8629-8633.
4. Masson, D., Tschopp, J. (1985) Isolation of a lytic pore-forming protein (perforin) from cytolytic T-lymphocytes. J. Biol. Chem. 260, 9069-9072.
5. Young, J. D-E., Hengartner, H., Podack, E. R., Cohn, Z. A. (1986) Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer cell activity. Cell 44, 849-859.
6. MacDermott, R. P., Schmidt, R. E., Caulfield, J. P., Hein, A., Bartley, G. T., Ritz, J., Schlossman, S. F., Austen, K. F., Stevens, R. L. (1985) Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from cloned natural killer cells during target cell lysis. J. Exp. Med. 162, 1771-1787.
7. Shi, L., Kraut, R., Aebersold, R., Greenberg, A. H. (1992) A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175, 553-566.
8. Shi, L., Kam, C-M., Powers, J. C., Aebersold, R., Greenberg, A. H. (1992) Purification of three cytotoxic lymphocyte granule proteases that induce apoptosis through distinct substrate and target cell interactions. J. Exp. Med. 176, 1521-1529.
9. Shiver, J. W., Su, L., Henkart, P. A. (1992) Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell 71, 315-322.
10. Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., Ley, T. J. (1994) Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76, 977-987.
11. Gershenfeld, H. K., Herschberger, R. J., Shows, T. B., Weissman, I. L. (1988) Cloning and chromosomal assignment of a human cDNA encoding a T cell-and natural killer cell-specific trypsin-like serine protease. Proc. Natl. Acad. Sci. USA 85, 1184-1188.
12. Schmid, J., Weissman, C. (1987) Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimtilated human leukocytes. J. Immunol. 139, 250-256.
13. Trapani, J. A., Klein, J. L., White, P. C., Dupont, B. (1988) Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes. Proc. Natl. Acad. Sci. USA 85, 6924-6928.
14. Haddad, P., Jenne, D. E., Tschopp, J., Clément, M-V., Mathieu-Mahul, D., Sasportes, M. (1990) Structure and evolutioary origin of the human granzyme H gene. Int. Immunol. 3, 57-61.
15. Meier, M., Kwong, P. C., Frégeau, C. J., Atkinson, E. A., Burrington, M., Ehrman, N., Sorensen, O., Lin, C. C., Wilkins, J., Bleackley, R. C. (1990) Cloning of a gene that encodes a new member of the human cytotoxic cell protease family. Biochemistry 29, 4042-4049.
16. Poe, M., Blake, J. T., Boulton, D. A., Gammon, M., Sigal, N. H., Wu, J. K., Zweerink, H. J. (1991) Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J. Biol. Chem. 266, 98-103.
17. Odake, S., Kam, C-M., Narasimhan, L., Poe, M., Blake, J. T., Krahenbuhl, O., Tschopp, J., Powers, J. C. (1991) Human and murine cytotoxic lymphocyte serine proteases: Subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 30, 2217-2227.
18. Smyth, M. J., Sayers, T. J., Wiltrout, T., Powers, J. C., Trapani, J. A. (1993) Met-ase: Cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. J. Immunol. 151, 6195-6205.
19. Fink, T. M., Lichter, P., Wekerle, H., Zimmer, M., Jenne, D. E. (1993) The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily. Genomics 18, 401-403.
20. Hanson, R. D., Hohn, P. A., Popescu, N. C., Ley, T. J. (1990) A cluster of hematopoetic serine protease genes is found on the same chromosomal band as the human α/δ T-cell receptor locus. Proc. Natl. Acad. Sci. USA 87, 960-963.
21. Harper, K., Mattei, M-G., Simon, D., Suzan, M., Guenet, J-L., Haddad, P., Sasportes, M., Goldstein, P. (1988) Proximity of the CTLA-1 serine esterase and the Tcr alpha loci in mouse and man. Immunogenetics 28, 439-444.
22. Baker, E., Sutherland, G. R., Smyth, M. J. (1994) The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3. Immunogenetics 39, 294-295.
23. Hameed, A., Lowery, D. M., Lichtenfeld, M., Podack, E. R. (1988) Characterization of three serine esterases isolated from human IL-2 activated killer cells. J. Immunol. 141, 3142-3147.
24. Sayers, T. J., Wiltrout, T. A., Smyth, M. J., Ottaway, K. S., Pilaro, A. M., Sowder, R., Henderson, L. E., Sprenger, H., Lloyd, A. R. (1994) Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia. J. Immunol. 152, 2289-2297.
25. Baker, E., Sayers, T. J., Sutherland, G. R., Smyth, M. J. (1994) The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. Immunogenetics 40, 235-237.
26. Sanger, F., Nicklen, S., Coulson, A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
27. von Heijne, G. (1986) A new method for predicting signal peptide cleavage sites. Nucleic Acids Res. 14, 4683-4690.
28. Nakajima, H., Park, H. L., Henkart, P. (1995) Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181, 1037-1046.
29. Smyth, M. J., Trapani, J. A. (1995) Granzymes: Exogenous proteinases that induce target cell apoptosis. Immunol. Today 16, 202-206.
30. Smyth, M. J., McGuire, M. J., Thia, K. Y. T. (1995) Expression of recombinant granzyme B. A processing and activation role for dipeptidyl peptidase I. J. Immunol. 154, 6299-6305.
31. Przetak, M. M., Yoast, S., Schmidt, B. F. (1995) Cloning of cDNA for human granzyme 3. Febs Lett. 364, 268-271.