Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

Biochemical Journal

Volumn 352, Issue 2, 2000, Pages 475-482

  Mao, M ^a   Fang, X ^a   Lu, Y ^a   LaPushin, R ^a   Bast R C , Jr ^a   Mills, G B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Atypical PKC; Epidermal growth factor; p70 6 ; Phosphoinositide 3 kinase; PKC inhibitor

Indexed keywords

GROWTH FACTOR; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BREAST CANCER; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; HUMANS; INDOLES; LYSOPHOSPHOLIPIDS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0034533061     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520475     Document Type: Article

References (45)

1. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
2. Calcium promotes cell survival through CaM-K kinase activation of the protein kinase-B pathway
3. The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism
4. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
5. Plalelet-derived growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: Role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase
6. Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser-473 kinase
7. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
8. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
9. cAMP stimulates protein kinase B in a worfmannin-insensitive manner
10. Protein kinase Cζ is a negative regulator of protein kinase B activity
11. Multiple biological responses activated by nuclear protein kinase C
12. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms
13. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
14. Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells
15. Protein kinase C isoforms in human airway smooth muscle cells: Activation of PKC-ζ during proliferation
16. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
17. Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-λ, ∈ and ζ
18. Modulating protein kinase C signal transduction
19. Evidence that atypical protein kinase C-ζ and atypical protein kinase C-ζ participate in Ras-mediated reorganization of the F-aclin cytoskeleton
20. Protein kinase C in the treatment of disease: Signal transduction pathways, inhibitors, and agents in development
21. Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway
22. The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase Cζ
23. Molecular cloning and characterization of a new member of the RAC protein kinase family: Association of the pleckstrin homology domain of three types of RAC protein kinase with protein klnase C subspecies and βγ subunits of G proteins
24. Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B
25. Lysophospholipids activate ovarian and breast cancer cells
26. PI 3-kinase γ and protein kinase C-ζ mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor
27. Translation control: Connecting mitogens and the ribosome
28. Phosphorylation sites in the autoinhibitory domain participate in p70 (s6k) activation loop phosphorylation
29. Structure and function of phosphoinositide 3-kinases
30. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
31. Bifurcation of lipid and protein kinase signals of P13Kγ to the protein kinases PKB and MAPK
32. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
33. Regulation of protein kinase C ζ by PI 3-kinase and PDK-1
34. Regulation of cell death protease caspase-9 by phosphorylation
35. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: Functional and physical interaction of EMT with phosphatidylinositol 3-kinase
36. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
37. The PTEN/MMAC1/TEP tumor suppressor gone decreases cell growth and induces apoptosis and anoikis in breast cancer cells
38. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
39. 2+ mobilization by Src homology 2 domain-containing inositol 5′-phosphalase (SHIP)
40. The inositol phosphatase SHIP inhibits Akt/PKB ataivation in B cells
41. Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport
42. p70 S6 kinase is regulated by protein kinase Cζ and participates in a phosphoinositide 3-kinase regulated signalling complex
43. p90(RSK) blocks Bad mediated cell death via a protein kinase C-dependent pathway
44. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
45. Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C