Protein kinase C isoforms in human airway smooth muscle cells: Activation of PKC-ζ during proliferation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 3 20-3, 1999, Pages

  Carlin, Steve ^c   Yang, Kenny X F ^a   Donnelly, Richard ^b   Black, Judith L ^c  

^a PRINCE HENRY HOSPITAL   (Australia)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c NONE

Author keywords

Atypical protein kinase C; Bronchial muscle cells; Hyperplasia; Protein kinase C isoenzymes

Indexed keywords

BOVINE SERUM ALBUMIN; GLYCOGEN SYNTHASE; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; PROTEIN KINASE C; THYMIDINE; TRITIUM;

ARTICLE; BRONCHUS MUSCLE; CELL DENSITY; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MITOGENESIS; MOLECULAR INTERACTION; MUSCLE FIBER CULTURE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY;

EID: 0032902085     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.3.l506     Document Type: Article

References (30)

1. Bandyopadhyay, G., M. L. Standaert, L. Zhao, B. Yu, A. Avignon, L. Galloway, P. Karnam, J. Moscat, and R. V. Farese. Activation of protein kinase C (α, Β, and ζ) by insulin in 3T3/L1 cells. J. Biol. Chem. 272: 2551-2558, 1997.
2. Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat. Protein kinase ζ isoform is critical for mitogenic signal transduction. Cell 74: 555-563, 1993.
3. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
4. Das, M., K. R. Stenmark, L. J. Ruff, and E. C. Dempsey. Selected isozymes of PKC contribute to augmented growth of fetal and neonatal bovine PA adventitial fibroblasts. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L1276-L1284, 1997.
5. Donnelly, R., K. X. F. Yang, M. B. Omary, S. Azhar, and J. L. Black. Expression of multiple isoenzymes of protein kinase C in airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 13: 253-256, 1995.
6. Fukumoto, S., Y. Nishizawa, M. Hosoi, H. Koyama, K. Yamakawa, S. Ohno, and H. Morii. Protein kinase-δ inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J. Biol. Chem. 272: 13816-13822, 1997.
7. Goldberg, M., and S. F. Steinberg. Tissue specific developmental regulation of protein kinase C isoforms. Biochem. Pharmacol. 51: 1089-1093, 1996.
8. Hirai, S., Y. Izumi, K. Higa, K. Kaibuchi, K. Mizuno, S. Osada, K. Suzuki, and S. Ohno. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta. EMBO J. 13: 2331-2340, 1994.
9. Hirst, S. J., B. L. J. Webb, M. A. Giembycz, P. J. Barnes, and C. H. C. Twort. Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase. Am. J. Respir. Cell Mol. Biol. 12: 149-161, 1995.
10. Hug, H., and T. F. Sarre. Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291: 329-343, 1993.
11. Isacke, C. M., J. Meisenhelder, K. D. Brown, K. L. Gould, S. J. Gould, and T. Hunter. Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and mammalian bombesin-related peptide, gastrin-releasing peptide. EMBO J. 5: 2889-2898, 1986.
12. Ishii, H., M. R. Jirousek, D. Koya, C. Takagi, P. Xia, A. Clermont, S.-E. Bursell, T. S. Kern, L. M. Ballas, W. F. Heath, L. E. Stramm, E. P. Feener, and G. L. King. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC inhibitor. Science 272: 728-731, 1996.
13. 2 and heparin are antiproliferative mediators for human airway smooth muscle cells in culture. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L514-L519, 1995.
14. Kariya, K. I., Y. Kawahara, T. Tsuda, H. Fukuzaki, and Y. Takai. Possible involvement of protein kinase C in platelet derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells. Atherosclerosis 63: 251-255, 1987.
15. Kazanietz, M. G., L. B. Areces, A. Bahador, H. Mischak, J. Goodnight, J. F. Mushinski, and P. M. Blumberg. Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol. Pharmacol. 44: 298-307, 1993.
16. Laemmli, U. Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
17. Liao, D.-F., B. Monia, N. Dean, and B. C. Berk. Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J. Biol. Chem. 272: 6146-6150, 1997.
18. Mischak, H., J. Goodnight, W. Kolch, G. Martiny-Baron, C. Schaechtle, M. G. Kazanietz, P. M. Blumberg, J. H. Pierce, and J. F. Mushinski. Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem. 268: 6090-6096, 1993.
19. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-613, 1992.
20. Panettieri, R. A. Airway smooth muscle cell growth, and proliferation. In: Airway Smooth Muscle: Development and Regulation of Contractility, edited by D. Raeburn and M. A. Giembycz. Basel: Birkhauser Verlag, 1994, p. 41-68.
21. Panettieri, R. A., M. D. Cohen, and G. Bilgen. ASM proliferation is inhibited by microinjection of the catalytic subunit of cAMP dependent protein kinase (Abstract). Am. Rev. Respir. Dis. 147: A252, 1993.
22. Panettieri, R. A., N. A. Rubinstein, B. Feuerstein, and M. I. Kotlikoff. Beta-adrenergic inhibition of ASM proliferation (Abstract). Am. Rev. Respir. Dis. 143: A608, 1991.
23. 2+ and activators of protein kinase C. Proc. Natl. Acad. Sci. USA 82: 8825-8839, 1985.
24. Qu, X., and R. Donnelly. Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? Am. J. Hypertens. 10: 1053-1057, 1997.
25. Rossetti, M., J.-P. Savineau, H. Crevel, and R. Marthan. Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L966-L971, 1995.
26. Standaert, M. L., L. Galloway, P. Karnam, G. Badyopadhyay, J. Moscat, and R. V. Farese. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. J. Biol. Chem. 272: 30075-30082, 1997.
27. Togashi, H., C. A. Hirshman, and C. W. Emala. Qualitative immunoblot analysis of PKC isoforms expressed in airway smooth muscle. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16): L603-L607, 1997.
28. Webb, B. L. J., M. A. Lindsay, J. Seybold, N. J. Brand, M. H. Yacoub, E.-B. Hadda, P. J. Barnes, I. M. Adcock, and M. Giembycz. Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level. Biochem. Pharmacol. 54: 199-205, 1997.
29. Yang, K. X. F., and J. L. Black. The involvement of protein kinase C in the contraction of human airway smooth muscle. Eur. J. Pharmacol. 275: 283-289, 1995.
30. Yang, K. X. F., and J. L. Black. Protein kinase C induced changes in human airway smooth muscle tone - the effects of calcium and sodium transport. Eur. J. Pharmacol. 315: 65-71, 1996.