Functional dominance among Hox genes: Repression dominates activation in the regulation of dpp

Development

Volumn 125, Issue 24, 1998, Pages 4949-4957

  Capovilla, Maria ^a,b   Botas, Juan ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Decapentaplegic; dpp674; Drosophila melanogaster; Hox genes; Phenotypic suppression; Posterior prevalence

Indexed keywords

PROTEIN;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO AXIS; ENHANCER REGION; GENE EXPRESSION; GENETIC REGULATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPRESSOR GENE;

ANIMALS; BINDING SITES; DNA FOOTPRINTING; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, HOMEOBOX; GENES, INSECT; GENES, REPORTER; HISTOCYTOCHEMISTRY; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0032431822     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Appel, B. and Sakonju, S. (1993). Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos. EMBO J. 12, 1099-109.
2. Averof, M. and Akam, M. (1995). Hox genes and the diversification of insect and crustacean body plans. Nature 376, 420-423.
3. Averof, M. and Patel, N. H. (1997). Crustacean appendage evolution associated with changes in Hox gene expression. Nature 388, 682-686.
4. Beachy, P. A., Krasnow, M. A., Gavis, E. R. and Hogness, D. S. (1988). An Ultrabithorax protein binds sequences near its own and the Antennapedia PI promoters. Cell 55, 1069-1081.
5. Beeman, R. W., Stuart, J. J., Brown, S. J. and Denell, R. E. (1993). Structure and function of the homeotic gene complex (HOM-C) in the beetle, Tribolium castaneum. BioEssays 15, 439-444.
6. Bienz, M. and Tremml, G. (1988). Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion. Nature 333, 576-578.
7. Botas, J. (1993). Control of morphogenesis and differentiation by HOM/Hox genes. Curr. Opin. Cell Biol. 5, 1015-1022.
8. Capovilla, M., Brandt, M. and Botas, J. (1994). Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell 76, 461-475.
9. Carroll, S. B. (1995). Homeotic genes and the evolution of arthropods and chordates. Nature 376, 479-485.
10. Chan, S. K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R. S. (1994). The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78, 603-615.
11. Duboule, D. (1991). Patterning in the vertebrate limb. Curr. Opin. Genet. Dev. 1, 211-216.
12. Sun, B., Hursh, D. A., Jackson, D. and Beachy, P. A. (1995). Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 14, 520-535.
13. Treisman, J., Gonczy, P., Vashishtha, M., Harris, E. and Desplan, C. (1989). A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 59, 553-562.
14. Tremml, G. and Bienz, M. (1989). Homeotic gene expression in the visceral mesoderm of Drosophila embryos. EMBO J. 8, 2677-2685.
15. Vachon, G., Cohen, B., Pfeifle, C., McGuffin, M. E., Botas, J. and Cohen, S. M. (1992). Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71, 437-450.
16. Wang, B. B., Muller-Immergluck, M. M., Austin, J., Robinson, N. T., Chisholm, A. and Kenyon, C. (1993). A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell 74, 29-42.