Mechanism of action of camptothecin

Annals of the New York Academy of Sciences

Volumn 803, Issue , 1996, Pages 44-49

  Liu, Leroy F ^a   Duann, Pu ^a   Lin, Ching Tai ^a   D'Arpa, Peter ^a   Wu, Jiaxi ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; UBIQUITIN;

CELL CYCLE S PHASE; CELL DIVISION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOTOXICITY; DNA DAMAGE; DNA REPLICATION; EPISOME; RNA TRANSCRIPTION;

EID: 0030481607     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb26375.x     Document Type: Conference Paper

References (14)

1. LI, L. H., T. J. FRASER, E. J. & OLIN B. K. BHUYAN. 1972. Action of camptothecin on mammalian cells in culture. Cancer Res. 32: 2643-2650.
2. HOLM, C., J. M. COVEY, D. KERRIGAN & Y. POMMIER. 1989. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and to II inhibitors in Chinese hamster DC3F cells. Cancer Res. 49: 6365-6368.
3. D'ARPA, P., C. BEARDMORE & L. F. LIU. 1990. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res. 50: 6919-6924.
4. ZHANG, H., P. D'ARPA & L. F. LIU. 1990. A model for tumor cell killing by topoisomerase poisons. Cancer Cells 2: 23-27.
5. TSAO, Y.-P., A. RUSSO, G. NYAMUSWA, R. SILBER & L. F. LIU. 1993. Interaction between replication forks and topoisomerase I-DNA cleavable complexes: Studies in a cell-free SV40 DNA replication system. Cancer Res. 53: 1-8.
6. HSIANG, Y. H., M. G. LIHOU & L. F. LIU. 1989. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49: 5077-5082.
7. TSAO, Y. P., P. D'ARPA & L. F. LIU. 1992. The involvement of active DNA synthesis in camptothecin-induced G2 arrest: Altered regulation of p34cdc2/cyclin B. Cancer Res. 52: 1823-1829.
8. NELSON, W. G. & M. B. KASTAN. 1994. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14: 1815-1823.
9. NITISS, J. & J. C. WANG. 1988. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. U.S.A. 85: 7501-7505.
10. NITISS, J. & J. C. WANG. 1991. Yeast as a genetic system in the dissection of the mechanism of cell-killing by topoisomerase-targeting anticancer drugs. In DNA Topoisomerase in Cancer. M. Potmesil & K. W. Kohn, Eds. :77-90. Oxford University Press. New York: 77-90.
11. GOLDWASSER, F., I. BAE, M. VALENTI, K. TORRES & Y. POMMIER. 1995. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute Anticancer Screen. Cancer Res. 55: 2116-2121.
12. KAUFMANN, S. 1991. Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line. Cancer Res. 51: 1129-1136.
13. ZHANG, H., J. C. WANG & H. F. LIU. 1988. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc. Natl. Acad. Sci. U.S.A. 85: 1060-1064.
14. KWON, H., A. N. IMBALZANO, P. A. KHAVARI, R. E. KINGSTON & M. R. GREEN. 1994. Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature 370: 477-481.