A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 25, 1997, Pages 13565-13570

  Pilch, Daniel S ^a,b   Xu, Zhitao ^c   Sun, Qun ^c   Lavoie, Edmond J ^b,c   Liu, Leroy F ^a,b   Breslauer, Kenneth J ^b,c  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Adenine thymine tracts; DNA bending; Isothermal calorimetry; Ligand induced stimulation of topoisomerase 1 mediated DNA cleavage; Minor groove width and hydration

Indexed keywords

5 PHENYLTERBENZIMIDAZOLE DERIVATIVE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; IMIDAZOLE DERIVATIVE; TERBENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL; ELECTROPHORETIC MOBILITY; ENZYME MECHANISM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; BENZIMIDAZOLES; BINDING SITES; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; INDOLES; LIGANDS; NETROPSIN; NUCLEIC ACID CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0031472259     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.25.13565     Document Type: Article

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