The potential role of apoptosis in human disease

Medical Principles and Practice

Volumn 9, Issue 3, 2000, Pages 151-163

  Fadeel, Bengt ^a   Orrenius, Sten ^a   Zhivotovsky, Boris ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Caspases; Fas APO 1 CD95; Therapeutic intervention

Indexed keywords

CYCLOSPORIN A; PROTEIN P53;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; CANCER; DEGENERATIVE DISEASE; GENE THERAPY; GRAFT REJECTION; HUMAN; HUNTINGTON CHOREA; INFECTION; LUNG NON SMALL CELL CANCER; NEUROLOGIC DISEASE; PARKINSON DISEASE; REVIEW; STROKE;

EID: 0034501149     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054240     Document Type: Review

References (72)

1. Cell deaths in normal vertebrate ontogeny
2. Death in embryonic systems
3. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
4. Cell death: The significance of apoptosis
5. Caspases as treatment targets in stroke and neurodegenerative diseases
6. Genetic control of programmed cell death in the nematode Caenorhabditis elegans
7. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
8. Cell death in development
9. A cellular poison cupboard
10. Apoptosis by death factor
11. All along the watchtower: On the regulation of apoptosis regulators
12. Apoptosis: The importance of being eaten
13. Phagocyte recognition of cells undergoing apoptosis
14. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
15. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
16. Dominant interfering Fas gene mutations in pair apoptosis in a human autoimmune lymphoproliferative syndrome
17. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
18. Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients
19. Perforin gene defects in familial hemophagocytic lymphohistiocytosis
20. Apoptosis in the effector phase of autoimmune diabetes, multiple sclerosis and thyroiditis
21. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
22. The role of calcium in the regulation of apoptosis
23. 2+ channels exposed to serum from patients with type I diabetes
24. Serum from patients with type 2 diabetes with neuropathy induces complement-independent, calcium-dependent apoptosis in cultured neuronal cells
25. Glucose and tolbutamide induce apoptosis in pancreatic β-cells
26. Neuronal cell death
27. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
28. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
29. Cleavage of huntingtin by apopain, a pro-apoptotic cysteine protease, is modulated by the polyglutamine tract
30. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
31. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
32. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
33. Caspase inhibition reduces apoptosis and increases survival of nigral transplants
34. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells
35. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells
36. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
37. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
38. A bacterial invasin induces macrophage apoptosis by binding directly to ICE
39. Inhibition of apoptosis in chlamydia-infected cells: Blockade of mitochondrial cytochrome c release and caspase activation
40. Rodent fibroblast tumors expressing human myc and ras genes: Growth, metastasis and endogenous oncogene expression
41. Induction of apoptosis in fibroblasts by c-myc protein
42. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
43. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
44. Bcl-2-family proteins: The role of the BH3 domain in apoptosis
45. Bax suppresses tumorigenesis and stimulates apoptosis in vivo
46. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
47. p53: Emergency brake and target for cancer therapy
48. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
49. Wild type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
50. An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferative normal and neoplastic cells
51. The Fas counterattack: Cancer as a site of immune privilege
52. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
53. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?
54. Apoptosis of vascular smooth muscle cells in atherosclerosis
55. 2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells
56. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
57. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
58. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
59. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus
60. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
61. The role of FasL-induced apoptosis in immune privilege
62. CD95 ligand in graft rejection
63. Apoptosis: Cell death defined by caspase activation
64. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis
65. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
66. Synthetic activation of caspases: Artificial death switches
67. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
68. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
69. Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
70. Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins
71. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
72. Increased bone marrow formation by prevention of osteoblast apoptosis with parathyroid hormone