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Volumn 237, Issue 1, 1997, Pages 14-18

p53: Emergency brake and target for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 0031586609     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1997.3834     Document Type: Article
Times cited : (33)

References (39)
  • 1
    • 0027756186 scopus 로고
    • p53: At the crossroads of molecular carcinogenesis and risk assessment
    • 1. Harris, C. C. (1993). p53: At the crossroads of molecular carcinogenesis and risk assessment. Science 262, 1980-1981.
    • (1993) Science , vol.262 , pp. 1980-1981
    • Harris, C.C.1
  • 2
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • 2. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. (1994). Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 3
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • 3. Ko, L. J., and Prives, C. (1996). p53: Puzzle and paradigm. Genes Dev. 10, 1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 5
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • 5. Hupp, T. R., Meek, D. W., Midgley, C. A., and Lane, D. P. (1992). Regulation of the specific DNA binding function of p53. Cell 71, 875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 7
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • 7. Sherr, C. J. (1996). Cancer cell cycles. Science 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 10
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • 10. Miyashita, T., and Reed, J. C. (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 12
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • 12. Yin, C., Knudson, C. M., Korsmeyer, S. J., and Van Dyke, T. (1996). Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385, 637-640.
    • (1996) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4
  • 14
    • 0030802364 scopus 로고    scopus 로고
    • A novel p53-inducible gene, PAG680, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis
    • 14. Israeli, D., Tessler, E., Haupt, Y., Elkeles, A., Wilder, S., Amson, R., Telerman, A., and Oren, M. (1997). A novel p53-inducible gene, PAG680, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J. 16, 4384-4392.
    • (1997) EMBO J. , vol.16 , pp. 4384-4392
    • Israeli, D.1    Tessler, E.2    Haupt, Y.3    Elkeles, A.4    Wilder, S.5    Amson, R.6    Telerman, A.7    Oren, M.8
  • 17
    • 0025784539 scopus 로고
    • Wild type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • 17. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., and Oren, M. (1991). Wild type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352, 345-347.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 18
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • 18. Canman, C. E., Gilmer, T. M., Coutts, S. B., and Kastan, M. B. (1995). Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9, 600-611.
    • (1995) Genes Dev. , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 19
    • 0028999429 scopus 로고
    • p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
    • 19. Haupt, Y., Rowan, S., and Oren, M. (1995). p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene 10, 1563-1571.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 20
    • 0029811984 scopus 로고    scopus 로고
    • Genetic determinants of p53-induced apoptosis and growth arrest
    • 20. Polyak, K., Waldman, T., He, T.-C., Kinzler, K. W., and Vogelstein, B. (1996). Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10, 1945-1952.
    • (1996) Genes Dev. , vol.10 , pp. 1945-1952
    • Polyak, K.1    Waldman, T.2    He, T.-C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 21
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • 21. Chen, X., Ko, L. J., Jayaraman, L., and Prives, C. (1996). p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10, 2438-2451.
    • (1996) Genes Dev. , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 22
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • 22. Walker, K. K., and Levine, A. J. (1996). Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc. Natl. Acad. Sci. USA 93, 15335-15340.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 23
    • 0030798557 scopus 로고    scopus 로고
    • The polyproline region of p53 is required to activate apoptosis but not growth arrest
    • 23. Sakamuro, D., Sabbatini, P., White, E., and Prendergast, G. C. (1997). The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15, 887-898.
    • (1997) Oncogene , vol.15 , pp. 887-898
    • Sakamuro, D.1    Sabbatini, P.2    White, E.3    Prendergast, G.C.4
  • 24
    • 0027244853 scopus 로고
    • The p53-mdm2 autoregulatory loop
    • 24. Wu, X., Bayle, H., Olson, D., and Levine, A. J. (1993). The p53-mdm2 autoregulatory loop. Genes Dev. 7, 1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, H.2    Olson, D.3    Levine, A.J.4
  • 25
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • 25. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 26
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • 26. Kubbutat, M. H. G., Jones, S. N., and Vousden, K. H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 27
    • 0027407260 scopus 로고
    • Wild type p53 adopts a "mutant"-like conformation when bound to DNA
    • 27. Halazonetis, T. D., Davis, L. J., and Kandil, A. N. (1993). Wild type p53 adopts a "mutant"-like conformation when bound to DNA. EMBO J. 12, 1021-1028.
    • (1993) EMBO J. , vol.12 , pp. 1021-1028
    • Halazonetis, T.D.1    Davis, L.J.2    Kandil, A.N.3
  • 28
    • 0028966935 scopus 로고
    • Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
    • 28. Takenaka, I., Morin, F., Seizinger, B. R., and Kley, N. (1995). Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J. Biol. Chem. 270, 5405-5411.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5405-5411
    • Takenaka, I.1    Morin, F.2    Seizinger, B.R.3    Kley, N.4
  • 29
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • 29. Hupp, T. R., Sparks, A., and Lane, D. P. (1995). Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83, 237-245.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 30
    • 0030961889 scopus 로고    scopus 로고
    • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
    • 30. Selivanova, G., Iotsova, V., Okan, I., Pritsche, M., Ström, M., Groner, B., Grafström, R. C., and Wiman, K. G. (1997). Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nature Med. 3, 632-638.
    • (1997) Nature Med. , vol.3 , pp. 632-638
    • Selivanova, G.1    Iotsova, V.2    Okan, I.3    Pritsche, M.4    Ström, M.5    Groner, B.6    Grafström, R.C.7    Wiman, K.G.8
  • 31
    • 0030996361 scopus 로고    scopus 로고
    • Synergistic activation of transcription by CBP and p53
    • 31. Gu, W., Shi, X.-L., and Roeder, R. G. (1997). Synergistic activation of transcription by CBP and p53. Nature 387, 819-823.
    • (1997) Nature , vol.387 , pp. 819-823
    • Gu, W.1    Shi, X.-L.2    Roeder, R.G.3
  • 33
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • 33. Gu, W., and Roeder, R. G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 34
    • 0028868527 scopus 로고
    • p53: A cell cycle regulator activated by DNA damage
    • 34. Selivanova, G., and Wiman, K. G. (1995). p53: A cell cycle regulator activated by DNA damage. Adv. Cancer Res. 66, 143-180.
    • (1995) Adv. Cancer Res. , vol.66 , pp. 143-180
    • Selivanova, G.1    Wiman, K.G.2
  • 35
    • 0030475375 scopus 로고    scopus 로고
    • Restoration of the transcription activation function to mutant p53 in human cancer cells
    • 35. Abarzua, P., LoSardo, J. E., Gubler, M. L., Spathis, R., Lu, Y.-A., Felix, A., and Neri, A. (1996). Restoration of the transcription activation function to mutant p53 in human cancer cells. Oncogene 13, 2477-2482.
    • (1996) Oncogene , vol.13 , pp. 2477-2482
    • Abarzua, P.1    LoSardo, J.E.2    Gubler, M.L.3    Spathis, R.4    Lu, Y.-A.5    Felix, A.6    Neri, A.7
  • 37
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53-related protein that can induce apoptosis
    • 37. Jost, C. A., Marin, M. C., and Kaelin, W. G., Jr. (1997). p73 is a human p53-related protein that can induce apoptosis. Nature 389, 191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin W.G., Jr.3
  • 38
    • 0029013273 scopus 로고
    • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • 38. Lee, S., Elenbaas, B., Levine, A. J., and Griffith, J. (1995). p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81, 1013-1020.
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levine, A.J.3    Griffith, J.4
  • 39
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the p53 tumor suppressor protein
    • 39. Okamoto, K., and Beach, D. (1994). Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J. 13, 4816-4822.
    • (1994) EMBO J. , vol.13 , pp. 4816-4822
    • Okamoto, K.1    Beach, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.