Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

Nature Medicine

Volumn 5, Issue 4, 1999, Pages 423-426

  Baize, Sylvain ^a,b   Leroy, Eric M ^a   Georges Courbot, M C ^a   Capron, Monique ^b   Lansoud Soukate, Joseph ^a   Debré, Patrice ^c   Fisher Hoch, Susan P ^d   McCormick, Joseph B ^d   Georges, Alain J ^a  

^a CENTRE INTERNATIONAL DE RECHERCHES MÉDICALES DE FRANCEVILLE   (Gabon)

^b INSTITUT PASTEUR DE LILLE   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Fondation Marcel Mérieux ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; VIRUS ANTIBODY;

APOPTOSIS; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; EBOLA VIRUS; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; VIRUS HEMORRHAGIC FEVER; VIRUS LOAD;

ANTIBODIES, VIRAL; ANTIGENS, CD28; APOPTOSIS; DISEASE OUTBREAKS; FAS LIGAND PROTEIN; GABON; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERFERON TYPE II; LEUKOCYTES; MEMBRANE GLYCOPROTEINS; NUCLEOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; UP-REGULATION; VIRAL CORE PROTEINS;

EBOLA VIRUS;

EID: 0032907635     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/7422     Document Type: Article

References (24)

1. Peters, C.J. & Khan, A.S. in Current Topics in Microbiology and Immunology Vol. 235 (ed. Klenk, H.-D.) 85-95 (Springer-Verlag, Berlin, 1999)
2. Ksiazek, T.C. et al. Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates. J. Clin. Microbiol. 30, 947-950 (1992).
3. Xu, L. et al. Immunization for Ebola virus infection. Nature Med. 4, 37-42 (1998).
4. Clark, E.A. & Ledbetter, J.A. How B and T cells talk to each other. Nature 367, 425-428 (1994).
5. Lowin, B., Hahne, M., Mattmann, C. & Tschopp, J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370, 650-653 (1994).
6. Kayagaki, N. et al. Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182, 1777-1783 (1995).
7. Kiener, P.A. et al. Human monocytic cells contain high levels of intracellular Fas ligand. Rapid release following cellular activation. J. Immunol. 159, 1594-1598 (1997).
8. Feldmann, H. et al. Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J. Virol. 70, 2208-2214 (1996).
9. Kroemer, G. The proto-oncogen Bcl-2 and its role in regulating apoptosis. Nature Med. 3, 614-620 (1997).
10. Miller, T., Beausang, L.A., Meneghini, M. & Lidgard, G. Death-induced changes to the nuclear matrix: the use of anti-nuclear matrix antibodies to study agents of apoptosis. Biotechniques 15, 1042-1047 (1993).
11. Jeon, S.H. et al. Expression of Tcf-1 mRNA and surface TCR-CD3 complexes are reduced during apoptosis of T cells. Int. Immunol. 10, 1519-1527 (1998).
12. Fisher-Hoch, S.P. et al. Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Inf. Dis. 152, 887-894 (1985).
13. Baskerville, A., Bowen, E.T., Platt, G.S., McArdell, L.B. & Simpson, D.I. The pathology of experimental Ebola virus infection in monkeys. J. Pathol. 125, 131-138 (1978).
14. Baskerville, A., Fisher-Hoch, S.P., Neild, G.H. & Dowsett, A.B. Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection. J. Pathol. 147, 199-209 (1985).
15. Jaax, N.K. et al. Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch. Pothol. Lab. Med. 120, 140-155 (1996).
16. Johnson, E., Jaax, N., White, J. & Jahrling, P. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. Int. J. Exp. Pathol. 76, 227-236 (1995).
17. Yang, Z.-Y. et al. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science. 279, 1034-1037 (1998).
18. Zaki, S.R., Greer, P.W., Goldsmith, C.S. & Coffield, L.M. in International Colloquium on Ebola Virus Research (Institute of Tropical Medicine , Antwerp, Belgium, 1996).
19. Gallimore, A. et al. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 1383-1393 (1998).
20. Suda, T., Hashimoto, H., Tanaka, M., Ochi, T. & Nagata, S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J. Exp. Med. 186, 2045-2050 (1997).
21. Tanaka, M., Itai, T., Adachi, M. & Nagata, S. Downregulation of Fas ligand by shedding. Nature Med. 4, 31-36 (1998).
22. Georges-Courbot, M.C. et al. Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon. Emerg. Infect. Dis. 3, 59-62 (1997).
23. WHO. Recommendations for management of viral haemorrhagic fevers in Africa, in Workshop on Viral Haemorrhagic Fevers (Sierra Leone, 1985).
24. Feldmann, H., Nichol, S.T., Schikore, M., Slenczka, W. & Klenk, H.-D. Glycosylation and oligomerization of the spike protein of Marburg virus. Virology 182, 353-356 (1991).