The vacuolating toxin of Helicobacter pylori: A few answers, many questions

Digestive and Liver Disease

Volumn 32, Issue SUPPL. 3, 2000, Pages

  Ricci, V ^a   Sommi, P ^a   Romano, M ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Vac A toxin; Vacuolar degeneration

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINO ACID; ANTIGEN; BACTERIAL ANTIGEN; BACTERIAL TOXIN; CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR; F ACTIN; HYDROLASE; PEPSINOGEN; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; PROTEIN TYROSINE PHOSPHATASE; VIRULENCE FACTOR;

AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GENE; CELL DAMAGE; CELL MEMBRANE PERMEABILITY; CELL VACUOLE; CHANNEL GATING; CONTROLLED STUDY; CYTOARCHITECTURE; DIARRHEA; ENDOCYTOSIS; ENDOSOME; EPITHELIUM CELL; GENE STRUCTURE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; OSMOSIS; PEPSIN SECRETION; PROTEIN BINDING; RECEPTOR BINDING; STOMACH ACID SECRETION; STOMACH EPITHELIUM; STOMACH MUCOSA;

EID: 0034490913     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1590-8658(00)80271-6     Document Type: Article

References (33)

1. Epithelial cytotoxicity, immune responses, and inflammatory components of Helicobacter pylori gastritis
2. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
3. Bafilomycin A 1 inhibits Helicobacter pylori- induced vacuolization of HeLa cells
4. Cytotoxicity of Helicobacter pylori on human gastric epithelial cells in vitro: Role of cytotoxin(s) and ammonia
5. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
6. The vacuolating cytotoxin of Helicobacter pylori
7. The clinical relevance of strain types of Helicobacter pylori
8. Persistence of Helicobacter pylori VacA toxin and vacuolating potential in cultured gastric epithelial cells
9. Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium
10. Molecular and cellular activities of Helicobacter pylori pathogenic factors
11. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase
12. An intracellular target for Helicobacter pylori vacuolating toxin
13. Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells
14. Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by the EGF receptor in HeLa cells
15. High cell sensitivity to Helicobacter pylori VacA toxin depends on a GPI-anchored protein and is not blocked by inhibition of the clathrin-mediated pathway of endocytosis
16. Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia
17. Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments
18. Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers
19. The acid activation of Helicobacter pylori toxin VacA: Structural and membrane binding studies
20. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein
21. Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin
22. New acquisitions in Helicobacter pylori characteristics
23. The effect of Helicobacter pylori on gastric acid secretion by isolated parietal cells from a guinea pig. Association with production of vacuolating toxin by H. pylori
24. Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells
25. Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation
26. Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: Role of VacA and CagA
27. Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells
28. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA
29. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin
30. Enterotoxic effect of the vacuolating toxin produced by Helicobacter pylori in Caco-2 cells
31. Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells
32. Helicobacter pylori vacuolating cytotoxin (VacA) disorganizes the cytoskeletal architecture of gastric epithelial cells
33. Immunohistochemical detection of Helicobacter pylori vacuolating cytotoxin in the hepatocytes of patients with isolated hypertransaminasaemia