High cell sensitivity to Helicobacter pylori VacA toxin depends on a GPI-anchored protein and is not blocked by inhibition of the clathrin-mediated pathway of endocytosis

Molecular Biology of the Cell

Volumn 11, Issue 11, 2000, Pages 3897-3909

  Ricci, V ^a   Galmiche, A ^a   Doye, A ^a   Necchi, V ^a   Solcia, E ^a   Boquet, P ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; BACTERIAL TOXIN; CHOLESTEROL; CLATHRIN; DYNAMIN; GLYCOSYLPHOSPHATIDYLINOSITOL; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LIPID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; SPHINGOLIPID; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

ARTICLE; CELL ACTIVITY; CELL STRUCTURE; CELL SURFACE; CELL TYPE; CELL VACUOLE; CONTROLLED STUDY; DEPOLARIZATION; ENDOCYTOSIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 0033748047     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.11.3897     Document Type: Article

References (78)

1. The pore-forming toxin proaerolysin is activated by furin
2. A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum
3. Adventures of a pore-forming toxin at the target cell surface
4. Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin
5. The clinical relevance of strain types of Helicobacter pylori
6. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: Association of specific vacA types with cytotoxin production and peptic ulceration
7. Inhibition of clathrin-coated pit assembly by an Eps15 mutant
8. AP-2/Eps15 interaction is required for receptor-mediated endocytosis
9. Helicobacter pylori: Its role in disease
10. How is Helicobacter pylori transmitted?
11. The vacuolating cytotoxin of Helicobacter pylori
12. An intracellular target for Helicobacter pylori vacuolating toxin
13. Purification and characterization of the vacuolating toxin from Helicobacter pylori
14. Acid-induced dissociation of VacA, the Helicobacter pylori cytotoxin, reveals its pattern of assembly
15. Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin
16. Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases
17. The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH
18. Cell vacuolization induced by Helicobacter pylori VacA toxin: Cell line sensitivity and quantitative estimation
19. Endocytosis of GPI-anchored proteins in human lymphocytes: Role of glycolipid-based domains, actin cytoskeleton, and protein kinases
20. Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin
21. How does Helicobacter pylori cause mucosal damage? The inflammatory response
22. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions to trypanosome research
23. Epithelial cytotoxicity, immune responses, and inflammatory components of Helicobacter pylori gastritis
24. Landing on lipid rafts
25. Spatial control of coated-pit dynamics in living cells
26. Binding and internalization of Helicobacter pylori vacuolating cytotoxin by epithelial cells
27. Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease
28. Helicobacter pylori infection
29. Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors
30. The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells
31. The emergence of clathrin-independent pinocytic pathways
32. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
33. Protein measurement with Folin phenol reagent
34. Binding of the Helicobacter pylori vacuolating cytotoxin to target cells
35. Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells
36. Further evidence of the toxic effect of ammonia produced by Helicobacter pylori urease on human epithelial cells
37. Association of diphtheria toxin with Vero cells. Demonstration of a receptor
38. The acid activation of Helicobacter pylori toxin VacA: Structural and membrane binding studies
39. Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers
40. Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin
41. Molecular and cellular activities of Helicobacter pylori pathogenic factors
42. Inhibition of coated pit formation in HEp-2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin
43. Intracellular transport of GPI-anchored proteins
44. The surface membrane of the small intestinal epithelial cell. I. Localization of adenyl cyclase
45. Helicobacter pylori in peptic ulcer disease
46. Helicobacter pylori infection and gastric carcinoma in a population of Japanese Americans in Hawaii
47. Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances
48. Fllipin-dependent inhibition of cholera toxin: Evidence for toxin internalization and activation through caveolae-like domains
49. Morphologic differentiation of HL-60 cells is associated with appearance of RPTPβ and induction of Helicobacter pylori VacA sensitivity
50. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity
51. Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells
52. Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments
53. Helicobacter pylori infection and the risk of gastric carcinoma
54. Regulated internalization of caveolae
55. Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity
56. CD14-dependent endotoxin internalization via a macropinocytic pathway
57. Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: Role of VacA and CagA
58. Cytotoxicity of Helicobacter pylori on human gastric epithelial cells in vitro: Role of cytotoxin(s) and ammonia
59. Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia
60. Caveolin, a protein component of caveolae membrane coats
61. Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis
62. Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by the EGF receptor in HeLa cells
63. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
64. Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
65. Persistence of Helicobacter pylori VacA toxin and vacuolating potential in cultured gastric epithelial cells
66. The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae
67. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity
68. The epidemiology of Helicobacter pylori infections
69. Unraveling the pathogenic role of Helicobacter pylori in peptic ulcer: Potential new therapies and vaccine
70. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
71. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: Possible implications for the mechanism of cellular vacuolation
72. Campylobacter-like organisms and surface epithelium abnormalities in active, chronic gastritis in humans: An ultrastructural study
73. Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes
74. A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation
75. Schistosomes, liver flukes and Helicobacter pylori
76. Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS
77. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase
78. Molecular response of gastric epithelial cells to Helicobacter pylori-induced cell damage