Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells

FEBS Letters

Volumn 399, Issue 1-2, 1996, Pages 127-130

  Chan, Err Cheng ^a   Chen, Kuei Tian ^a   Lin, Yuh Ling ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cellular signaling; Helicobacter pylori; Pepsinogen; Peptic ulcer; Phosphorylation; Vacuolating toxin

Indexed keywords

CALCIUM; CYCLIC AMP; CYTOTOXIN; INOSITOL PHOSPHATE; PEPSINOGEN;

ARTICLE; CELL CULTURE; CELL VACUOLE; CONTROLLED STUDY; DIGESTIVE TRACT SECRETION; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IN VITRO STUDY; PEPTIC ULCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; BACTERIAL PROTEINS; HELA CELLS; HELICOBACTER PYLORI; HUMANS; PEPSINOGENS; PHOSPHOLIPIDS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0030577391     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01304-X     Document Type: Article

References (27)

1. [1] Leunk, R.D. (1991) Rev. Infect. Dis. 13, S686-S689.
2. [2] Cover, T.L., Halter, S.A. and Blaser, M.J. (1992) Hum. Pathol. 23, 1004-1010.
3. [3] Cover, T.L. and Blaser, M.J. (1992) J. Biol. Chem. 267, 10570-10575.
4. [4] Cover, T.L., Cao, P., Lind, C.D., Tham, K.T. and Blaser, M.J. (1993) Infect. Immun. 61, 5008-5012.
5. [5] Phadnis, S.H., Ilver, D., Janzon, L., Normark, S. and Westblom, T.U. (1994) Infect. Immun. 62, 1557-1565.
6. [6] Cover, T.L., Dooley, C.P. and Blaser, M.J. (1990) Infect. Immun. 58, 603-610.
7. [7] Figura, N., Guglielmetti, P., Rossolini, A., Barberi, A. and Gusi, G. (1989) J. Clin. Microbiol. 27, 115-116.
8. [8] Telford, J.L., Ghiara, P., Dell'Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., Tecce, M.F., Censini, S., Covacci, A., Xiang, Z., Papini, E., Montecucco. C., Parente, L. and Rappuoli, R. (1994) J. Exp. Med. 179, 1653-1658.
9. [9] Tee, W., Lambert, J.R. and Dwyer, B. (1995) J. Clin. Microbiol. 3, 1203-1205.
10. [10] Telford, J.L., Covacci, A., Ghiara, P., Montecucco, C. and Rappuoli, R. (1994) Trends Biotechnol. 12, 420-426.
11. [11] Marchetti, M., Arico, B., Burroni, D., Figura, N., Rappuoli, R. and Ghiara, P. (1995) Science 267, 1655-1658.
12. [12] Eaton, K.A., Morgan, D.R. and Krakowka, S. (1989) Infect. Immun. 57, 1119-1125.
13. [13] Eaton, K.A., Morgan, D.R. and Krakowka, S. (1996) Helicobacter Today Newslett. 1, 3.
14. [14] Brady, C.E., Hadfield, T.L. and Hyatt, J.R. (1988) Gastroenterol. 94, 923-926.
15. [15] Cover, T.L., Puryear, W., Perez-Perez, G.I. and Blaser, M.J. (1991) Infect. Immun. 59, 1264-1270.
16. [16] Burnatowska-Hledin, M.A. and Spielman, W.S. (1989) J. Clin. Invest. 83, 84-89.
17. [17] Grynkiewicz, G., Poenie, M. and Tsien, R. (1985) J. Biol. Chem. 260, 3440-3450.
18. [18] Jennings, L.K., Fox, C.F., Kouns. W.C., Mckays, C.P. and Ballou, L.R. (1990) J. Biol. Chem. 265, 3815-3822.
19. [19] Cave, T.R. and Cave, D.R. (1991) Scand. J. Gastroenterol. 26, S9-14.
20. [20] Schlamowitz, M. and Peterson, L.U. (1959) J. Biol. Chem. 234, 3137-3139.
21. [21] Laemmli, U.K. (1970) Nature 277, 680-685.
22. [22] Raufman, J.P. (1992) Gastroenterology 102, 699-710.
23. [23] Nakano, O., Sakamoto, C., Nishisaki, H., Konda, Y., Matsuda, K., Wade, K., Nagao, M. and Matozaki, T. (1990) Life Sci. 47, 647-654.
24. [24] Raffaniello, R.D. and Raufman, J.P. (1992) Am. J. Physiol. 26, G452-459.
25. [25] Raufman, J.P., Berger, S., Cosowsky. L. and Straus, E.W. (1986) Biochem. Biophys. Res. Commun. 137, 281-285.
26. [26] Raufman, J.P. and Cosowsky, L. (1987) Biochim. Biophys. Acta 928, 199-207.
27. [27] Sutliff, V.E., Raufman, J.P., Jenen, R.T. and Gardner, J.D. (1986) Am. J. Physiol. 14, G96-G102.