Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA

Journal of Experimental Medicine

Volumn 187, Issue 1, 1998, Pages 135-140

  Molinari, Maurizio ^a   Salio, Mariolina ^b   Galli, Carmela ^a   Norais, Nathalie ^c   Rappuoli, Rino ^c   Lanzavecchia, Antonio ^b   Montecucco, Cesare ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c CHIRON VACCINES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRULENCE FACTOR;

ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENDOSOME; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNITY; LYMPHOCYTE PROLIFERATION; LYSOSOME; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; CELL TRANSFORMATION, VIRAL; HELICOBACTER PYLORI; HERPESVIRUS 4, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES; VIRULENCE;

EID: 0031974233     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.1.135     Document Type: Article

References (30)

1. Blaser, M.J. 1993. Helicobacter pylori: microbiology of a "slow" bacterial infection. Trends Microbiol. 1:255-260.
2. Goodwin, G.S., and M.M. Mendall. 1997. Helicobacter pylori infection. Lancet. 349:265-269.
3. Eurogast Study Group. 1993. An international association between Helicobater pylori infection and gastric cancer. Lancet. 341:1359-1362.
4. Gensini, S., G. Lange, Z. Xiang, J.E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, and A. Covacci. 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA. 93:14648-14653.
5. Cover, T.L. 1996. The vacuolating cytotoxin of Helicobacter pylori. Mol. Microbiol. 20:241-246.
6. Papini, E., B. Satin, G. Bucci, M. de Bernard, J. Telford, R. Manetti, R. Rappuoli, M. Zerial, and G. Montecucco. 1997. The small GTP-binding protein Rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin. EMBO (Eur. Mol. Biol. Organ.) J. 16:15-24.
7. Molinari, M., G. Galli, N. Norais, J.L. Telford, R. Rappuoli, J.P. Luzio, and G. Montecucco. 1997. Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers. J. Biol. Chem. 272:25339-25344.
8. Satin, B., N. Norais, J. Telford, R. Rappuoli, M. Murgia, C. Montecucco, and E. Papini. 1997. Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation. J. Biol. Chem. 272:25022-25028.
9. Watts, C. 1997. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15:821-850.
10. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature. 314:537-539.
11. Pond, L., and C. Watts. 1997. Characterization of transport of newly assembled, T cell-stimulatory MHC class II-peptide complexes from MHG class II compartments to the cell surface. J. Immunol. 159:543-553.
12. Watts, G., and W. Davidson. 1988. Endocytosis and recycling of specific antigen by human B cell lines. EMBO (Eur. Mol. Biol. Organ.) J. 7:1937-1945.
13. Davidson, H.W., and G. Watts. 1989. Epitope-directed processing of specific antigen by B lymphocytes. J. Cell Biol. 109: 85-92.
14. Colonna, M., E.G. Brooks, M. Falco, G.B. Ferrara, and J.L. Strominger. 1993. Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C. Science. 260: 1121-1124.
15. Shimizu, Y., and R. DeMars. 1989. Production of human cells expressing individual transferred HLA-A, -B, -C genes using a HLA-A, -B, -C null human cell line. J. Immunol. 142: 3320-3328.
16. Miller, W.E., H.S. Earp, and N. Raab-Traub. 1995. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor. J. Virol. 69: 4390-4398.
17. Wolf, P.R., and H. L. Ploegh. 1995. How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu. Rev. Cell Dev. Biol. 11:267-306.
18. Ziegler, K., and E.R. Unanue. 1982. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine with inhibition of antigen presentation to T cells. Proc. Natl. Acad. Sci. USA. 79:175-178.
19. Harding, C.V., and H.J. Geuze. 1993. Antigen processing and intracellular traffic of antigens and MHC molecules. Curr. Opin. Cell Biol. 5:596-605.
20. Amigorena, S., J.R. Drake, P. Webster, and I. Mellman. 1994. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature. 369:113-120.
21. Cresswell, P. 1994. Assembly, transport and function of MHC class II molecules. Annu. Rev. Immunol. 12:259-293.
22. Pieters, J., O. Bakke, and B. Dobberstein. 1993. The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J. Cell Sci. 106: 831-846.
23. Harding, C.V., and E.R. Unanue. 1989. Antigen processing and intracellular Ia: possible roles of endocytosis and protein synthesis in Ia function. J. Immunol. 142:12-19.
24. Davidson, H.W., P.A. Reid, A. Lanzavecchia, and C. Watts. 1991. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell. 67: 105-116.
25. Pinet, V., M.S. Malnati, and E.O. Long. 1994. Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen. J. Immunol. 152:4852-4860.
26. Zhong, G., P. Romagnoli, and R.N. Germain. 1997. Related lecucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein J. Exp. Med. 185:429-438.
27. Raposo, G., H.W. Nijman, W. Stoorvogel, R. Lejendekker, C.V. Harding, C.J.M. Melief, and H.J. Geuze. 1996. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183:1161-1172.
28. Peters, P.J., J. Borst, V. Oorschot, M. Fukuda, O. Krahenbuhl, J. Tschopp, J.W. Slot, and H.J. Geuze. 1991. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 173:1099-1109.
29. Kägi, D., B. Ledermann, K. Bürki, R.M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14: 207-232.
30. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.