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Volumn 37, Issue 2, 2000, Pages 433-442

Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; IODINE 125;

EID: 0033929821     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.02013.x     Document Type: Article
Times cited : (83)

References (57)
  • 1
    • 0032498627 scopus 로고    scopus 로고
    • A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum
    • Abrami, L., Fivaz, M., Glauser, P.E., Parton, R.G., and van der Goot, F.G. (1998) A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum. J Cell Biol 140: 525-540.
    • (1998) J Cell Biol , vol.140 , pp. 525-540
    • Abrami, L.1    Fivaz, M.2    Glauser, P.E.3    Parton, R.G.4    Van Der Goot, F.G.5
  • 2
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori
    • Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton, J.C., Cao, P., Peek, R.M., Jr, Tummuru, M.K., Blaser, M.J., and Cover, T.L. (1995) Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270: 17771-17777.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek R.M., Jr.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 3
    • 0028818757 scopus 로고
    • Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant
    • de Bernard, M., Papini, E., de Filippis, V., Gottardi, E., Telford, J., Manetti, R., et al. (1995) Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant. J Biol Chem 270: 23937-23940.
    • (1995) J Biol Chem , vol.270 , pp. 23937-23940
    • De Bernard, M.1    Papini, E.2    De Filippis, V.3    Gottardi, E.4    Telford, J.5    Manetti, R.6
  • 4
    • 0030703647 scopus 로고    scopus 로고
    • Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol
    • de Bernard, M., Arico, B., Papini, E., Rizzuto, R., Grandi, G., Rappuoli, R., et al. (1997) Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol. Mol Microbiol 26: 665-674.
    • (1997) Mol Microbiol , vol.26 , pp. 665-674
    • De Bernard, M.1    Arico, B.2    Papini, E.3    Rizzuto, R.4    Grandi, G.5    Rappuoli, R.6
  • 5
    • 0031741917 scopus 로고    scopus 로고
    • Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol
    • de Bernard, M., Burroni, D., Papini, E., Rappuoli, R., Telford, J., and Montecucco, C. (1998) Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol. Infect Immun 66: 6014-6016.
    • (1998) Infect Immun , vol.66 , pp. 6014-6016
    • De Bernard, M.1    Burroni, D.2    Papini, E.3    Rappuoli, R.4    Telford, J.5    Montecucco, C.6
  • 6
    • 0034602831 scopus 로고    scopus 로고
    • The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein
    • de Bernard, M., Moschioni, M., Napolitani, G., Rappuoli, R., and Montecucco, C. (2000) The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. EMBO J 19: 48-56.
    • (2000) EMBO J , vol.19 , pp. 48-56
    • De Bernard, M.1    Moschioni, M.2    Napolitani, G.3    Rappuoli, R.4    Montecucco, C.5
  • 7
    • 0031671674 scopus 로고    scopus 로고
    • Ligand-induced endocytosis of the asialoglycoprotein receptor: Evidence for heterogeneity in subunit oligomerization
    • Bider, M.D., and Spiess, M. (1998) Ligand-induced endocytosis of the asialoglycoprotein receptor: evidence for heterogeneity in subunit oligomerization. FEBS Lett 434: 37-41.
    • (1998) FEBS Lett , vol.434 , pp. 37-41
    • Bider, M.D.1    Spiess, M.2
  • 8
    • 0023710642 scopus 로고
    • The 'molten globule' state is involved in the translocation of proteins across membranes?
    • Bychkova, V.E., Pain, R.H., and Ptitsyn, O.B. (1988) The 'molten globule' state is involved in the translocation of proteins across membranes? FEBS Lett 238: 231-234.
    • (1988) FEBS Lett , vol.238 , pp. 231-234
    • Bychkova, V.E.1    Pain, R.H.2    Ptitsyn, O.B.3
  • 9
    • 0033984479 scopus 로고    scopus 로고
    • Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin
    • Coelho, A., Andrade, J.R.C., Vicente, A.C.P., and DiRita, V.J. (2000) Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin. Infect Immun 68: 1700-1705.
    • (2000) Infect Immun , vol.68 , pp. 1700-1705
    • Coelho, A.1    Andrade, J.R.C.2    Vicente, A.C.P.3    DiRita, V.J.4
  • 10
    • 0029923910 scopus 로고    scopus 로고
    • The vacuolating cytotoxin of Helicobacter pylori
    • Cover, T.L. (1996) The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 20: 241-246.
    • (1996) Mol Microbiol , vol.20 , pp. 241-246
    • Cover, T.L.1
  • 11
    • 0026062034 scopus 로고
    • Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin
    • Cover, T.L., Puryear, W., Pérez-Pérez, G.I., and Blaser, M.J. (1991) Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin. Infect Immun 59: 1264-1270.
    • (1991) Infect Immun , vol.59 , pp. 1264-1270
    • Cover, T.L.1    Puryear, W.2    Pérez-Pérez, G.I.3    Blaser, M.J.4
  • 12
    • 0026713040 scopus 로고
    • Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases
    • Cover, T.L., Vaughn, S.G., Cao, P., and Blaser, M.J. (1992) Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases. J Infect Dis 166: 1073-1078.
    • (1992) J Infect Dis , vol.166 , pp. 1073-1078
    • Cover, T.L.1    Vaughn, S.G.2    Cao, P.3    Blaser, M.J.4
  • 13
    • 0027479881 scopus 로고
    • Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin
    • Cover, T.L., Reddy, L.Y., and Blaser, M.J. (1993) Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin. Infect Immun 61: 1427-1431.
    • (1993) Infect Immun , vol.61 , pp. 1427-1431
    • Cover, T.L.1    Reddy, L.Y.2    Blaser, M.J.3
  • 14
    • 0028308711 scopus 로고
    • Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    • Cover, T.L., Tummuru, M.K.R., Cao, P., Thompson, S.A., and Blaser, M.J. (1994) Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 269: 10566-10573.
    • (1994) J Biol Chem , vol.269 , pp. 10566-10573
    • Cover, T.L.1    Tummuru, M.K.R.2    Cao, P.3    Thompson, S.A.4    Blaser, M.J.5
  • 15
    • 0030809535 scopus 로고    scopus 로고
    • Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly
    • Cover, T.L., Hanson, P.I., and Heuser, J.E. (1997) Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J Cell Biol 138: 759-769.
    • (1997) J Cell Biol , vol.138 , pp. 759-769
    • Cover, T.L.1    Hanson, P.I.2    Heuser, J.E.3
  • 16
    • 0033515072 scopus 로고    scopus 로고
    • The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH
    • Czajkowsky, D.M., Iwamoto, H., Cover, T.L., and Shao, Z. (1999) The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH. Proc Natl Acad Sci USA 96: 2001-2006.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2001-2006
    • Czajkowsky, D.M.1    Iwamoto, H.2    Cover, T.L.3    Shao, Z.4
  • 18
    • 0021015433 scopus 로고
    • Membrane receptors for bacterial toxins
    • Eidels, L., Proia, R.L., and Hart, D.A. (1983) Membrane receptors for bacterial toxins. Microbiol Rev 47: 596-620.
    • (1983) Microbiol Rev , vol.47 , pp. 596-620
    • Eidels, L.1    Proia, R.L.2    Hart, D.A.3
  • 19
    • 0032982467 scopus 로고    scopus 로고
    • Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium
    • Fiocca, R., Necchi, V., Sommi, P., Ricci, V., Telford, J., Cover, T.L., et al. (1999) Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium. J Pathol 188: 220-226.
    • (1999) J Pathol , vol.188 , pp. 220-226
    • Fiocca, R.1    Necchi, V.2    Sommi, P.3    Ricci, V.4    Telford, J.5    Cover, T.L.6
  • 20
    • 0029822812 scopus 로고    scopus 로고
    • Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells
    • Garner, J.A., and Cover, T.L. (1996) Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells. Infect Immun 64: 4197-4203.
    • (1996) Infect Immun , vol.64 , pp. 4197-4203
    • Garner, J.A.1    Cover, T.L.2
  • 21
    • 0032964320 scopus 로고    scopus 로고
    • Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells
    • Hertle, R., Hilger, M., Weingardt-Kocher, S., and Walev, I. (1999) Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells. Infect Immun 67: 817-825.
    • (1999) Infect Immun , vol.67 , pp. 817-825
    • Hertle, R.1    Hilger, M.2    Weingardt-Kocher, S.3    Walev, I.4
  • 22
    • 0033007098 scopus 로고    scopus 로고
    • VacA from Helicobacter pylori: A hexameric chloride channel
    • Iwamoto, H., Czajkowsky, D.M., Cover, T.L., Szabo, G., and Shao, Z. (1999) VacA from Helicobacter pylori: a hexameric chloride channel. FEBS Lett 450: 101-104.
    • (1999) FEBS Lett , vol.450 , pp. 101-104
    • Iwamoto, H.1    Czajkowsky, D.M.2    Cover, T.L.3    Szabo, G.4    Shao, Z.5
  • 23
    • 0033989808 scopus 로고    scopus 로고
    • A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection
    • Keenan, J., Day, T., Neal, S., Cook, B., Perez-Perez, G., Allardyce, R., et al. (2000) A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection. FEMS Microbiol Lett 182: 259-264.
    • (2000) FEMS Microbiol Lett , vol.182 , pp. 259-264
    • Keenan, J.1    Day, T.2    Neal, S.3    Cook, B.4    Perez-Perez, G.5    Allardyce, R.6
  • 24
    • 0029793619 scopus 로고    scopus 로고
    • Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment
    • Kock, J., Borst, E.M., and Schlicht, H.J. (1996) Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment. J Virol 70: 5827-5831.
    • (1996) J Virol , vol.70 , pp. 5827-5831
    • Kock, J.1    Borst, E.M.2    Schlicht, H.J.3
  • 25
    • 15444347280 scopus 로고    scopus 로고
    • RTX toxins recognize a beta2 integrin on the surface of human target cells
    • Lally, E.T., Kieba, I.R., Sato, A., Green, C.L., Rosenbloom, J., Korostoff, J., et al. (1997) RTX toxins recognize a beta2 integrin on the surface of human target cells. J Biol Chem 272: 30463-30469.
    • (1997) J Biol Chem , vol.272 , pp. 30463-30469
    • Lally, E.T.1    Kieba, I.R.2    Sato, A.3    Green, C.L.4    Rosenbloom, J.5    Korostoff, J.6
  • 26
    • 0025297466 scopus 로고
    • Insertion and translocation of proteins into and through membranes
    • Lazdunski, C.J., and Benedetti, H. (1990) Insertion and translocation of proteins into and through membranes. FEBS Lett 268: 408-414.
    • (1990) FEBS Lett , vol.268 , pp. 408-414
    • Lazdunski, C.J.1    Benedetti, H.2
  • 27
    • 0023912268 scopus 로고
    • Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
    • Leunk, R.D.P.T.J., David, B.C., Kraft, W.G., and Morgan, D.R. (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 26: 93-99.
    • (1988) J Med Microbiol , vol.26 , pp. 93-99
    • Leunk, R.D.P.T.J.1    David, B.C.2    Kraft, W.G.3    Morgan, D.R.4
  • 29
    • 0029898566 scopus 로고    scopus 로고
    • Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin
    • Lupetti, P., Heuser, J.E., Manetti, R., Massari, P., Lanzavecchia, S., Bellon, P.L., et al. (1996) Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J Cell Biol 133: 801-807.
    • (1996) J Cell Biol , vol.133 , pp. 801-807
    • Lupetti, P.1    Heuser, J.E.2    Manetti, R.3    Massari, P.4    Lanzavecchia, S.5    Bellon, P.L.6
  • 30
    • 0031873020 scopus 로고    scopus 로고
    • Binding of the Helicobacter pylori vacuolating cytotoxin to target cells
    • Massari, P., Manetti, R., Burroni, D., Nuti, S., Norais, N., Rappuoli, R., et al. (1998) Binding of the Helicobacter pylori vacuolating cytotoxin to target cells. Infect Immun 66: 3981-3984.
    • (1998) Infect Immun , vol.66 , pp. 3981-3984
    • Massari, P.1    Manetti, R.2    Burroni, D.3    Nuti, S.4    Norais, N.5    Rappuoli, R.6
  • 31
    • 0030868990 scopus 로고    scopus 로고
    • Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers
    • Molinari, M., Galli, C., Norais, N., Telford, J.L., Rappuoli, R., Luzio, J.P., et al. (1997) Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers. J Biol Chem 272: 25339-25344.
    • (1997) J Biol Chem , vol.272 , pp. 25339-25344
    • Molinari, M.1    Galli, C.2    Norais, N.3    Telford, J.L.4    Rappuoli, R.5    Luzio, J.P.6
  • 32
    • 0031974233 scopus 로고    scopus 로고
    • Selective inhibition of li-dependent antigen presentation by Helicobacter pylori toxin VacA
    • Molinari, M., Salio, M., Galli, C., Norais, N., Rappuoli, R., Lanzavecchia, A., et al. (1998a) Selective inhibition of li-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med 187: 135-140.
    • (1998) J Exp Med , vol.187 , pp. 135-140
    • Molinari, M.1    Salio, M.2    Galli, C.3    Norais, N.4    Rappuoli, R.5    Lanzavecchia, A.6
  • 34
    • 0029559119 scopus 로고
    • Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin
    • Moll, G., Papini, E., Colonna, R., Burroni, D., Telford, J., Rappuoli, R., et al. (1995) Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin. Eur J Biochem 234: 947-952.
    • (1995) Eur J Biochem , vol.234 , pp. 947-952
    • Moll, G.1    Papini, E.2    Colonna, R.3    Burroni, D.4    Telford, J.5    Rappuoli, R.6
  • 35
    • 0000641269 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin and associated pathogenic factors
    • Alouf J.E., and Freer, J.H. (eds). London and San Diego, CA: Academic Press
    • Montecucco, C., Papini, E., de Bernard, M., Telford, J.L., and Rappuoli, R. (1999) Helicobacter pylori vacuolating cytotoxin and associated pathogenic factors. In The Comprehensive Sourcebook of Bacterial Protein Toxins. Alouf J.E., and Freer, J.H. (eds). London and San Diego, CA: Academic Press, pp. 264-286.
    • (1999) The Comprehensive Sourcebook of Bacterial Protein Toxins , pp. 264-286
    • Montecucco, C.1    Papini, E.2    De Bernard, M.3    Telford, J.L.4    Rappuoli, R.5
  • 38
    • 0028067979 scopus 로고
    • Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments
    • Papini, E., de Bernard, M., Milia, E., Bugnoli, M., Zerial, M., Rappuoli, R., et al. (1994) Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments. Proc Natl Acad Sci USA 91: 9720-9724.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9720-9724
    • Papini, E.1    De Bernard, M.2    Milia, E.3    Bugnoli, M.4    Zerial, M.5    Rappuoli, R.6
  • 39
    • 0031032509 scopus 로고    scopus 로고
    • The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin
    • Papini, E., Satin, B., Bucci, C., de Bernard, M., Telford, J.L., Manetti, R., et al. (1997) The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin. EMBO J 16: 15-24.
    • (1997) EMBO J , vol.16 , pp. 15-24
    • Papini, E.1    Satin, B.2    Bucci, C.3    De Bernard, M.4    Telford, J.L.5    Manetti, R.6
  • 40
    • 0028138521 scopus 로고
    • Regulated internalization of caveolae
    • Parton, R.G., Joggerst, B., and Simons, K. (1994) Regulated internalization of caveolae. J Cell Biol 127: 1199-1215.
    • (1994) J Cell Biol , vol.127 , pp. 1199-1215
    • Parton, R.G.1    Joggerst, B.2    Simons, K.3
  • 41
    • 0026572982 scopus 로고
    • Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes
    • Pure, E., and Tardelli, L. (1992) Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes. Proc Natl Acad Sci USA 89: 114-117.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 114-117
    • Pure, E.1    Tardelli, L.2
  • 42
    • 0030663325 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia
    • Ricci, V., Sommi, P., Fiocca, R., Romano, M., Solcia, E., and Ventura, U. (1997) Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia. J Pathol 183: 453-459.
    • (1997) J Pathol , vol.183 , pp. 453-459
    • Ricci, V.1    Sommi, P.2    Fiocca, R.3    Romano, M.4    Solcia, E.5    Ventura, U.6
  • 43
    • 0030764202 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation
    • Satin, B., Norais, N., Telford, J., Rappuoli, R., Murgia, M., Montecucco, C., et al. (1997) Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation. J Biol Chem 272: 25022-25028.
    • (1997) J Biol Chem , vol.272 , pp. 25022-25028
    • Satin, B.1    Norais, N.2    Telford, J.3    Rappuoli, R.4    Murgia, M.5    Montecucco, C.6
  • 44
    • 0028365481 scopus 로고
    • Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarities with the IgA protease type of exported protein
    • Schmitt, W., and Haas, R. (1994) Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol 12: 307-319.
    • (1994) Mol Microbiol , vol.12 , pp. 307-319
    • Schmitt, W.1    Haas, R.2
  • 45
    • 0032563331 scopus 로고    scopus 로고
    • Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by the EGF receptor in HeLa cells
    • Seto, K., Hayashi-Kuwabara, Y., Yoneta, T., Suda, H., and Tamaki, H. (1998) Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by the EGF receptor in HeLa cells. FEBS Lett 431: 347-350.
    • (1998) FEBS Lett , vol.431 , pp. 347-350
    • Seto, K.1    Hayashi-Kuwabara, Y.2    Yoneta, T.3    Suda, H.4    Tamaki, H.5
  • 46
    • 0031751816 scopus 로고    scopus 로고
    • Persistence of Helicobacter pylori VacA toxin and vacuolating potential in cultured gastric epithelial cells
    • Sommi, P., Ricci, V., Fiocca, R., Necchi, V., Romano, M., Telford, J.L., et al. (1998) Persistence of Helicobacter pylori VacA toxin and vacuolating potential in cultured gastric epithelial cells. Am J Physiol 275: G681-G688.
    • (1998) Am J Physiol , vol.275
    • Sommi, P.1    Ricci, V.2    Fiocca, R.3    Necchi, V.4    Romano, M.5    Telford, J.L.6
  • 47
    • 13044317274 scopus 로고    scopus 로고
    • Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity
    • Szabo, I., Brutsche, S., Tombola, F., Moschioni, M., Satin, B., Telford, J.L., et al. (1999) Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J 18: 5517-5527.
    • (1999) EMBO J , vol.18 , pp. 5517-5527
    • Szabo, I.1    Brutsche, S.2    Tombola, F.3    Moschioni, M.4    Satin, B.5    Telford, J.L.6
  • 48
    • 0028908420 scopus 로고
    • Cytotoxin production by Helicobacter pylori from patients with upper gastrointestinal tract diseases
    • Tee, W., Lambert, J.R., and Dwyer, B. (1995) Cytotoxin production by Helicobacter pylori from patients with upper gastrointestinal tract diseases. J Clin Microbiol 33: 1203-1205.
    • (1995) J Clin Microbiol , vol.33 , pp. 1203-1205
    • Tee, W.1    Lambert, J.R.2    Dwyer, B.3
  • 49
    • 0028355422 scopus 로고
    • Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
    • Telford, J.L., Ghiara, P., Dell'Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., et al. (1994) Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 179: 1653-1658.
    • (1994) J Exp Med , vol.179 , pp. 1653-1658
    • Telford, J.L.1    Ghiara, P.2    Dell'Orco, M.3    Comanducci, M.4    Burroni, D.5    Bugnoli, M.6
  • 50
    • 0032981962 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: Possible implications for the mechanism of cellular vacuolation
    • Tombola, F., Carlesso, C., Szabo, I., de Bernard, M., Reyrat, J.M., Telford, J.L., et al. (1999a) Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophys J 76: 1401-1409.
    • (1999) Biophys J , vol.76 , pp. 1401-1409
    • Tombola, F.1    Carlesso, C.2    Szabo, I.3    De Bernard, M.4    Reyrat, J.M.5    Telford, J.L.6
  • 51
    • 0032749462 scopus 로고    scopus 로고
    • Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori
    • Tombola, F., Oregna, F., Brutsche, S., Szabo, I., Del Giudice, G., Rappuoli, R., et al. (1999b) Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori. FEBS Lett 460: 221-225.
    • (1999) FEBS Lett , vol.460 , pp. 221-225
    • Tombola, F.1    Oregna, F.2    Brutsche, S.3    Szabo, I.4    Del Giudice, G.5    Rappuoli, R.6
  • 52
  • 53
    • 0033621333 scopus 로고    scopus 로고
    • A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation
    • Vinion-Dubiel, A.D., McClain, M.S., Czajkowsky, D.M., Iwamoto, H., Ye, D., Cao, P., et al. (1999) A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation. J Biol Chem 274: 37736-37742.
    • (1999) J Biol Chem , vol.274 , pp. 37736-37742
    • Vinion-Dubiel, A.D.1    McClain, M.S.2    Czajkowsky, D.M.3    Iwamoto, H.4    Ye, D.5    Cao, P.6
  • 54
    • 84920247287 scopus 로고
    • Unidentified curved bacilli on gastric epithelium in active chronic gastritis
    • Warren, J.R., and Marshall, B.J. (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1: 1273-1275.
    • (1983) Lancet , vol.1 , pp. 1273-1275
    • Warren, J.R.1    Marshall, B.J.2
  • 55
    • 0031577601 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS
    • Yahiro, K., Niidome, T., Hatakeyama, T., Aoyagi, H., Kurazono, H., Padilla, P.I., et al. (1997) Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS. Biochem Biophys Res Commun 238: 629-632.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 629-632
    • Yahiro, K.1    Niidome, T.2    Hatakeyama, T.3    Aoyagi, H.4    Kurazono, H.5    Padilla, P.I.6
  • 56
    • 0033579575 scopus 로고    scopus 로고
    • Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta
    • Yahiro, K., Niidome, T., Kimura, M., Hatakeyama, T., Aoyagi, H., Kurazono, H., et al. (1999) Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem 274: 36693-36699.
    • (1999) J Biol Chem , vol.274 , pp. 36693-36699
    • Yahiro, K.1    Niidome, T.2    Kimura, M.3    Hatakeyama, T.4    Aoyagi, H.5    Kurazono, H.6
  • 57
    • 0033515453 scopus 로고    scopus 로고
    • Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin
    • Ye, D., Willhite, D.C., and Blanke, S.R. (1999) Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin. J Biol Chem 274: 9277-9282.
    • (1999) J Biol Chem , vol.274 , pp. 9277-9282
    • Ye, D.1    Willhite, D.C.2    Blanke, S.R.3


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