Cooperativity in the inhibition of P-Glycoprotein-mediated daunorubicin transport: Evidence for half-of-the-sites reactivity

Archives of Biochemistry and Biophysics

Volumn 383, Issue 1, 2000, Pages 91-98

  Wang, E J ^a   Casciano, C N ^a   Clement, R P ^a   Johnson, W W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cooperativity; Half of the sites reactivity; MDR; Mechanism; P Glycoprotein

Indexed keywords

DAUNORUBICIN; GLYCOPROTEIN P;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG TRANSPORT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; TRANSPORT KINETICS; XENOBIOTIC METABOLISM;

ANIMALIA;

EID: 0034326834     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2000.2004     Document Type: Article

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