Two transport binding sites of P-glycoprotein are unequal yet contingent: Initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1481, Issue 1, 2000, Pages 63-74

  Wang, Er jia ^a   Casciano, Christopher N ^a   Clement, Robert P ^a   Johnson, William W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Kinetics; Mechanism; Mixed type inhibition; Multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASCORBIC ACID; COLCHICINE; DITHIOTHREITOL; GLYCOPROTEIN P; MANNITOL; NICARDIPINE; PROGESTERONE; PROPRANOLOL; QUINIDINE; VERAPAMIL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; HYDROLYSIS; KINETICS; MITOCHONDRIAL MEMBRANE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; TUMOR CELL; XENOBIOTIC METABOLISM;

ADENOSINE TRIPHOSPHATASES; ATP-BINDING CASSETTE TRANSPORTERS; BENZIMIDAZOLES; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CELL MEMBRANE; FLUORESCENT DYES; KINETICS; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0034739274     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(00)00125-4     Document Type: Article

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