Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates

Infection and Immunity

Volumn 66, Issue 2, 1998, Pages 514-520

  Johansson, Eva Liz ^a   Rask, Carola ^a   Fredriksson, Margareta ^a   Eriksson, Kristina ^a   Czerkinsky, Cecil ^a   Holmgren, Jan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN B SUBUNIT; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MEDROXYPROGESTERONE ACETATE;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; FEMALE; FEMALE GENITAL TRACT INFECTION; GENITAL TRACT INFECTION; HUMORAL IMMUNITY; IMMUNIZATION; INTRANASAL DRUG ADMINISTRATION; INTRAVAGINAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031905971     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.2.514-520.1998     Document Type: Article

References (39)

1. Ahlstedt, S., B. Carlsson, S. P. Fällström, L. A. Hansson, J. Holmgren, G. Lidin-Janson, B. S. Lindblad, U. Jodal, B. Kaijser, A. Sohl-Åkerlund, and C. Wadsworth. 1977. Antibodies in human serum and milk induced by enterobacteria and food proteins. Proc. Ciba Found. Symp. 46:115-134.
2. Aizpurua, H. J., and G. J. Russell-Jones. 1988. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding. J. Exp. Med. 167:440-451.
3. Bergquist, C., T. Lagergård, M. Lindblad, and J. Holmgren. 1995. Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates. Infect. Immun. 63:2021-2025.
4. Bergquist, C., E.-L. Johansson, T. Lagergård, J. Holmgren, and A. Rudin. 1997. Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. 65:2676-2684.
5. Brunham, R. C., C.-C. Kuo, L. Cles, and K. K. Holmes. 1983. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect. Immun. 39:1491-1494.
6. Cotter, T. W., Q. Meng, Z.-L. Shen, Y.-X. Zhang, H. Su, and H. D. Caldwell. 1995. Protective efficacy of a major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection. Infect. Immun. 63:4704-4714.
7. Cui, Z. D., D. Tristram, L. J. LaScolea, T. Kwiatowski, Jr., S. Kopti, and P. L. Ogra. 1991. Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization. Infect. Immun. 59:1465-1469.
8. Czerkinksky, C., L.-Å. Nilsson, H. Nygren, Ö. Ouchterlony, and A. Tarkovski. 1983. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65:109-121.
9. Czerkinsky, C., M. W. Russell, N. Lycke, M. Lindblad, and J. Holmgren. 1989. Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues. Infect. Immun. 57:1072-1077.
10. Czerkinsky, C., A.-M. Svennerholm, M. Quiding, R. Jonsson, and J. Holmgren. 1991. Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans. Infect. Immun. 59:996-1001.
11. Fidel, P. L., Jr., M. E. Lynch, D. H. Conaway, L. Tait, and J. D. Sobel. 1995. Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity. Infect. Immun. 63:547-553.
12. Gallichan, G. S., and K. L. Rosenthal. 1995. Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. Vaccine 13:1589-1595.
13. Haneberg, B., D. Kendall, H. M. Amerongen, F. M. Apter, J.-P. Kraehenbuhl, and M. R. Neutra. 1994. Induction of specific immunoglobulin A in the small intestine, colon-rectum and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect. Immun. 62:15-23.
14. Hopkins, S., J.-P. Kraehenbuhl, F. Schödel, A. Potts, D. Peterson, P. de Gandi, and D. Nardelli-Haefliger. 1995. A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization. Infect. Immun. 63:3279-3286.
15. Johansson, E., M. Fredriksson, M. Lindblad, H. Caldwell, C. Czerkinsky, and J. Holmgren. 1995. Cholera toxin and its B-subunit as mucosal immunogens and carrier/adjuvant molecules for inducing genital immunity. Clin. Immunol Immunopathol. 76:S43-S44.
16. Lebens, M., S. Johansson, J. Osek, M. Lindblad, and J. Holmgren. 1993. Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines. Bio Technology 11:1574-1578.
17. Lehner, T., C. Panagiotidi, L. A. Bergmeier, L. Tao, R. Brookes, A. Ceahng, and S. E. Adams. 1995. Genital-associated lymphoid tissue in female nonhuman primates. Adv. Mucosal Immunol. 371A:357-365.
18. Lehner, T., Y. Wang, M. Cranage, L. A. Bergmeier, E. Mitchell, L. Tao, G. Hall, M. Dennis. N. Cook, R. Brookes. L. Klavinskis, L Jones, C. Doyle, and R. Ward. 1996. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Med. 2:767-775.
19. Lycke, N. 1986. A sensitive method for the detection of specific antibody production in different isotypes from single lamina propria plasma cells. Scand. J. Immunol. 24:393-403.
20. McDermott, M. R., and J. Bienenstock. 1979. Evidence for a common mucosal immune system. I. Migration of B immunoblasts into intestinal, respiratory and genital tissues. J. Immunol. 122:1892-1898.
21. McKenzie. S., and J. F. Halsey. 1984. Cholera toxin B-subunit as a carrier protein to stimulate a mucosal immune response. J. Immunol. 133:1818-1824.
22. Menge, A. C., S. M. Michalek, M. W. Russell, and J. Mestecky. 1993. Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunit. Infect. Immun. 61:2162-2171.
23. Mestecky, J. 1987. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7:265-276.
24. Nedrud, J. G., X. P. Liang, and M. E. Lamm. 1989. Oral immunization with Sendai virus in mice. Curr. Top. Microbiol. Immunol. 146:117-122.
25. Parr, E. L., M. B. Parr, and M. Thapar. 1988. A comparison of specific antibody responses in mouse vaginal fluid after immunization by several routes. J. Reprod. Immun. 14:165-176.
26. Parr, M. B., and E. L. Parr. 1986. Effects of oestradiol-17β and progesterone on the number of plasma cells in uteri of ovariectomized mice. J. Reprod. Fertil. 77:91-97.
27. Parr, M. B., and E. L. Parr. 1990. Antigen recognition in the female reproductive tract: uptake of intraluminal protein tracers in the mouse vagina. J. Reprod. Immunol. 17:101-114.
28. Parr, M. B., and E. L. Parr. 1994. Mucosal immunity in the female and male reproductive tracts, p. 677-689. In P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee, and J. Bienenstock (ed.). Handbook of mucosal immunology. Academic Press, Inc., San Diego, Calif.
29. Quiding- Järbrink, M., G. Granström, I. Nordstr̈m, J. Holmgren, and C. Czerkinsky. 1995. Induction of compartmentalized B-cell responses in human tonsils. Infect. Immun. 63:853-857.
30. Quiding-Järbrink, M., I. Nordström, G. Granström, A. Kilander, M. Jertborn, E. C. Butcher, A. I. Lazarovits, J. Holmgrcn, and C. Czerkinsky. 1997. Differential expression of tissue-specific adhesion molecules on human circulating antibody-formine cells after systemic, enteric, and nasal immuniza- tions a molecular basis for the compartmemalization of effector B cell responses. J. Clin. Invest. 99:1281-1286.
31. Russell, M. W., Z. Moldoveanu, P. L. White, G. J. Sibert, J. Mestecky, and S. Michalek. 1996. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
32. Svennerholm, A.-M., and J. Holmgren. 1978. Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure. Curr. Microbiol. 1:19-23.
33. Svennerholm, A. M., D. A. Sack, J. Holmgren, and P. K. Bardhan. 1982. Intestinal antibody responses after immunisation with cholera B subunit, Lancet 6:305-308.
34. Thapar, M. A., E. L. Parr, and M. B. Parr. 1990. Secretory immune responses in mouse vaginal fluid after pelvic, parenteral or vaginal immunization. Immunology 70:121-125.
35. Wassén, L., K. Schön, J. Holmgren, M. Jertborn, and N. Lycke. 1996. Local intravaginal vaccination of the female genital tract. Scand. J. Immunol. 44:408-114.
36. Whaley, K. J., L. Zeitlin, R. A. Barratt, T. E. Hoen, and R. A. Cone. 1994. Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. J. Infect. Dis, 169:647-649.
37. Wira, C. R., and D. A. Sullivan. 1985. Estradiol and progesterone regulation of immunoglobulin A and G and secretory component in cervicovaginal secretions of the rat. Biol. Reprod. 32:90-95.
38. Wira, C. R., and R. M. Rossoll. 1995. Antigen presenting cells in the female reproductive tract: influence of the estrous cycle on antigen presentation by uterine epithelial and stromal cells. Endocrinology 136:4526-4534.
39. Wira, C. R., and R. M. Rossoll. 1995. Antigen presenting cells in the female reproductive tract: influence of sex hormones on antigen presentation in the vagina. Immunology 84:505-508.