Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection

Infection and Immunity

Volumn 65, Issue 2, 1997, Pages 640-644

  Yamamoto, Masafumi ^a   McDaniel, Larry S ^a,b,c   Kawabata, Keiko ^a   Briles, David E ^a   Jackson, Raymond J ^a   McGhee, Jerry R ^a   Kiyono, Hiroshi ^a,d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHOLERA TOXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; IMMUNOLOGICAL ADJUVANT; PROTEIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMORAL IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

EID: 0031018902     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.2.640-644.1997     Document Type: Article

References (37)

1. Anderson, P., D. H. Smith, D. L. Ingram, J. Wilkins, P. F. Wehrie, and V. M. Howie. 1977. Antibody of polyribophosphate of Haemophilus influenzae type b in infants and children: effect of immunization with polyribophosphate. J. Infect. Dis. 136:557-562.
2. Benton, K. A., M. P. Everson, and D. E. Briles. 1995. A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect. Immun. 63:448-455.
3. Berry, A. M., R. A. Lock, D. Hansman, and J. C. Paton. 1989. Contribution of autolysin to virulence of Streptococcus pneumoniae. Infect. Immun. 57: 2324-2330.
4. Berry, A. M., J. Yother, D. E. Briles, D. Hansman, and J. C. Paton. 1989. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect. Immun. 57:2037-2042.
5. Briles, D. E., J. D. King, M. A. Gray, L. S. McDaniel, E. Swiatlo, and K. A. Benton. 1996. PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice. Vaccine 14:858-867.
6. Briles, D. E., R. C. Tart, E. Swiatlo, J. P. Dillard, P. Smith, K. A. Benton, B. A. Ralph, A. B. Walter, M. J. Crain, S. K. Hollingshead, and L. S. McDaniel. Pneumococcal diversity: considerations for new vaccine strategies with an emphasis on pneumococcal surface protein A. Infect. Agents Dis., in press.
7. Burke, J. P., J. O. Klein, H. M. Gezon, and M. Finland. 1971. Pneumococcal bacteremia. Am. J. Dis. Child. 121:353-359.
8. Cowan, M. J., A. J. Ammann, D. W. Wara, V. M. Howie, L. Schultz, N. Doyle, and M. Kaplan. 1978. Pneumococcal polysaccharide immunization in infants and children. Pediatrics 62:721-727.
9. Crain, M. J., W. D. Waltman II, J. S. Turner, J. Yother, D. F. Talkington, L. S. McDaniel, B. M. Gray, and D. E. Briles. 1990. Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae. Infect. Immun. 58:3293-3299.
10. Damme, M. C., M.-P. Sory, T. Biot, J. P. Vaerman, and G. R. Cornelis. 1992. Oral immunization against cholera toxin with a live Yersinia enterocolitica carrier in mice. Gastroenterology 103:520-531.
11. Elson, C. O., and W. Ealding. 1984. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 132:2736-2741.
12. Gotschlich, E. C., I. Goldschneider, M. L. Lepow, and R. Gold. 1977. The immune response to bacterial polysaccharides in man, p. 391. In E. Harber and R. Krause (ed.), Antibodies in human diagnosis and therapy. Raven Press, New York, N.Y.
13. Gray, B. M., H. C. Dillion, and D. E. Briles. 1983. Epidemiological studies of Streptococcus pneumoniae in infants: development of antibody to phosphocholine. J. Clin. Microbiol. 18:1102-1107.
14. Gray, B. M. 1995. Pneumococcal infections in an era of multiple antibiotic resistance. Adv. Pediat. Infect. Dis. 11:55-100.
15. Hensel, A., N. Stockhofe-Zurwieden, K. Petzoldt, and W. Lubitz. 1995. Oral immunization of pigs with viable or inactivated Actinobacillus pleuropneumoniae serotype 9 induces pulmonary and systemic antibodies and protects against homologous aerosol challenge. Infect. Immun. 63:3048-3053.
16. Jackson, R. J., K. Fujihashi, J. Xu-Amano, H. Kiyono, C. O. Elson, and J. R. McGhee. 1993. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun. 61:4272-4274.
17. Jackson, R. J., K. Fujihashi, H. Kiyono, and J. R. McGhee. 1996. Luminometry: a novel bioluminescent method enhances the quantitation of mucosal and systemic antibody responses. J. Immunol. Methods 190:184-197.
18. Kiyono, H., J. Bienenstock, J. R. McGhee, and P. B. Ernst. 1992. The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg. Immunol. 4:54-62.
19. Klein, J. O., D. W. Teele, J. L. Sloyer, Jr., J. H. Ploussard, V. Howie, P. H. Makela, and P. Karma. 1982. Use of pneumococcal vaccine for prevention of recurrent episodes of otitis media, p. 305-310. In J. B. Robbins, J. C. Hilland, and J. C. Sadoff (ed.), Bacterial Vaccine. Thieme-Stratton Inc., New York, N.Y.
20. Langermann, S., S. R. Palaszynski, J. E. Burlein, S. Koenig, M. S. Hanson, D. E. Briles, and C. K. Stover. 1994. Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guerin vaccines expressing pneumococcal surface protein A. J. Exp. Med. 180:2277-2286.
21. Lycke, N., and J. Holmgren. 1986. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 59:301-308.
22. MacLeod, C. M., R. G. Hodge, M. Heidelberger, and W. G. Bernhard. 1945. Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J. Exp. Med. 82:445-465.
23. Marinaro, M., H. F. Staats, T. Hiroi, R. J. Jackson, M. Coste, P. N. Boyaka, N. Okahashi, M. Yamamoto, H. Kiyono, H. Bluethmann, K. Fujihashi, and J. R. McGhee. 1995. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155:4621-4629.
24. McDaniel, L. S., and D. E. Briles. 1986. Monoclonal antibodies against surface components of Streptococcus pneumoniae, p. 146-164. In A. J. L. Macario and E. C. de Macario (ed.), Monoclonal antibodies against bacteria. Academic Press, Inc., Orlando, Fla.
25. McDaniel, L. S., G. Scott, J. F. Kearney, and D. E. Briles. 1984. Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae. J. Exp. Med. 160:386-397.
26. McDaniel, L. S., G. Scott, K. Widenhofer, J. Carroll, and D. E. Briles. 1986. Analysis of a surface protein of Streptococcus pneumoniae recognized by protective monoclonal antibodies. Microb. Pathog. 1:519-531.
27. McDaniel, L. S., J. Yother, M. Vijayakumar, L. McGarry, W. R. Guild, and D. E. Briles. 1987. Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA). J. Exp. Med. 165:381-394.
28. McDaniel, L. S., W. D. Waltman II, B. Gray, and D. E. Briles. 1987. A protective monoclonal antibody that reacts with a novel antigen of pneumococcal teichoic acid. Microb. Pathog. 3:249-260.
29. McDaniel, L. S., J. S. Sheffield, P. Delucchi, and D. E. Briles. 1991. PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular serotype. Infect. Immun. 59:222-228.
30. McGowen, J. E., Jr., L. Bratton, D. O. Klein, and M. Finland. 1973. Bacteremia in febrile children seen in a "walk-in" pediatric clinic. N. Engl. J. Med. 288:1309-1312.
31. Orcel, B., B. Delclaux, M. Baud, and J. P. Derenne. 1994. Oral immunization with bacterial extracts for protection against acute bronchitis in elderly institutionalized patients with chronic bronchitis. Eur. Respir. J. 7:446-452.
32. Talkington, D. F., D. L. Crimmins, D. C. Voellinger, J. Yother, and D. E. Briles. 1991. A 43-kilodalton pneumococcal surface protein, PspA: isolation, protective abilities, and structural analysis of the amino-terminal sequence. Infect. Immun. 59:1285-1289.
33. Tart, R., L. S. McDaniel, B. A. Ralph, and D. E. Briles. 1996. Truncated Streptococcus pneumoniae PspA molecules elicit cross-protective immunity against pneumococcal challenge in mice. J. Infect. Dis. 173:380-386.
34. Teele, D. W., S. I. Pelton, M. J. Grant, J. Herskowitz, D. J. Rosen, C. E. Allen, R. S. Wimmer, and J. O. Klein. 1975. Bacteremia in febrile children under 2 years of age: results of cultures of blood of 600 consecutive febrile children seen in a "walk-in" clinic. J. Pediatr. 87:227-230.
35. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Med. Exp. 178:1309-1320.
36. Xu-Amano, J., R. J. Jackson, K. Fujihashi, H. Kiyono, H. F. Staats, and J. R. McGhee. 1994. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine 12:903-911.
37. Yother, J., and J. M. White. 1994. Novel surface attachment mechanism for the Streptococcus pneumoniae protein PspA. J. Bacteriol. 176:2976-2985.