Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cells

Journal of Neuroscience

Volumn 20, Issue 3, 2000, Pages 937-948

  Banks, Matthew I ^a   Pearce, Robert A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Extrasynaptic receptors; GABA(A) receptors; Hippocampus; IPSCs; Patch clamp; Receptor kinetics

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIPPOCAMPUS; HORMONE RECEPTOR INTERACTION; INHIBITORY POSTSYNAPTIC POTENTIAL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REGULATORY MECHANISM; SECOND MESSENGER;

EID: 0034143418     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-03-00937.2000     Document Type: Article

References (71)

1. 2+ from brain tissue during activity. Nature 308:734-736.
2. A IPSCs: dissociation of blocking and prolonging effects. Anesthesiology 90:120-134.
3. A receptors. Soc Neurosci Abstr 23:104.
4. A,slow. J Neurosci 18:1305-1317.
5. Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ (1997) The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci USA 94:11031-11036.
6. 2+ via changes of their desensitization kinetics: an in situ patch-clamp and single-cell PCR study. J Neurosci 18:2437-2448.
7. A receptors. J Physiol (Lond) 497:753-759.
8. A receptors suggest differential targeting of receptor subtypes. J Neurosci 19:2960-2973.
9. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones. J Physiol (Lond) 420:207-221.
10. Clements JD, Lester RA, Tong G, Jahr CE, Westbrook GL (1992) The time course of glutamate in the synaptic cleft. Science 258:1498-1501.
11. Colquhoun D, Jonas P, Sakmann B (1992) Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. J Physiol (Lond) 458:261-287.
12. Dudel J, Franke C, Hatt H (1992) Rapid activation and desensitization of transmitter-liganded receptor channels by pulses of agonists. Ion Channels 3:207-260.
13. Edwards FA, Konnerth A, Sakmann B, Takahashi T (1989) A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflügers Arch 414:600-612.
14. 2 subunit and gephyrin. Nat Ncurosci 1:563-571.
15. Frerking M, Wilson M (1996) Saturation of postsynaptic receptors at central synapses? Curr Opin Neurobiol 6:395-403.
16. Frerking M, Borges S, Wilson M (1995) Variation in GABA mini amplitude is the consequence of variation in transmitter concentration. Neuron 15:885-895.
17. A-receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci 14:5302-5324.
18. A receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons. J Neurosci 17:7220-7227.
19. A Receptors - an allosteric, state-dependent mechanism determined by the gamma-subunit. J Physiol (Lond) 506:609-625.
20. A receptor gating kinetics on the alpha-subunit isoform: implications for structure-function relations and synaptic transmission. J Physiol (Lond) 489:529-543.
21. Halasy K, Somogyi P (1993) Distribution of GABAergic synapses and their targets in the dentate gyrus of rat: a quantitative immunoelectron microscopic analysis. J Hirnforsch 34:299-308.
22. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
23. Harris KM, Marshall PE, Landis DM (1985) Ultrastructural study of cholecystokinin-immunoreactive cells and processes in area CA1 of the rat hippocampus. J Comp Neurol 233:147-158.
24. Hausser M, Clark BA (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-678.
25. Hestrin S (1992) Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron 9:991-999.
26. Hill MW, Reddy PA, Covey DF, Rothman SM (1998) Contribution of subsaturating GABA concentrations to IPSCs in cultured hippocampal neurons. J Neurosci 18:5103-5111.
27. A receptors in the human hippocampal formation. J Neurosci 8:1370-1383.
28. Inoue M, Oomura Y, Yakushiji T, Akaike N (1986) Intracellular calcium ions decrease the affinity of the GABA receptor. Nature 324:156-158.
29. Isaacson JS, Solis JM, Nicoll RA (1993) Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 10:165-175.
30. Jack JJ, Noble D, Tsien RW (1983) Electric current flow in excitable cells. Oxford: Oxford UP.
31. Jackson MB (1992) Cable analysis with the whole-cell patch clamp. Theory and experiment. Biophys J 61:756-766.
32. A channel responses to brief agonist pulses. Neuron 15:181-191.
33. Jones MV, Westbrook GL (1996) The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci 19:96-101.
34. Jones MV, Westbrook GL (1997) Shaping of IPSCs by endogenous calcineurin activity. J Neurosci 17:7626-7633.
35. A receptor. J Neurosci 18:8590-8604.
36. A receptors on cultured hippocampal cells correlate only partially with functional synapses. Eur J Neurosci 11:1256-1264.
37. A receptor is associated with the receptor subunit composition. J Physiol (Lond) 492:431-443.
38. Legendre P (1998) A reluctant gating mode of glycine receptor channels determines the time course of inhibitory miniature synaptic events in zcbrafish hindbrain neurons. J Neurosci 18:2856-2870.
39. Lerma J, Herranz AS, Herreras O, Abraira V, Martin DR (1986) In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res 384:145-155.
40. Lester RA, Clements JD, Westbrook GL, Jahr CE (1990) Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature 346:565-567.
41. A receptor main conductance state of mouse spinal cord neurones in culture. J Physiol (Lond) 410:479-499.
42. A receptors open? Neuron 12:61-71.
43. 2+ on GABA-activated currents in cerebellar granule cells in culture. J Membr Biol 142:209-216.
44. A receptors. J Physiol (Lond) 515:711-727.
45. A receptors in cultured murine cerebellar granule cells. J Physiol (Lond) 503:353-369.
46. Miesenbock G, Deangelis DA, Rothman JE (1998) Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394:192-195.
47. A receptors in acutely dissociated P2-P6 rat hippocampal neurons. J Neurophysiol 79:1321-1328.
48. A receptors. J Neurosci 19:2474-2488.
49. A receptors on cerebellar granule cells as determined by a quantitative immunogold method. J Neurosci 15:2948-2960.
50. A receptor number underlie variation in GABA mini amplitude. Neuron 19:697-709.
51. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693-1703.
52. A responses in rat hippocampus. Neuron 10:189-200.
53. A receptors in central synapses. J Neurosci 19:578-588.
54. A receptor function by PKA and PKC in adult hippocampal neurons. J Neurosci 19:674-683.
55. A/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies. J Neurosci 7:1866-1886.
56. Rosenmund C, Westbrook GL (1993) Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10:805-814.
57. Sather W, Dieudonne S, MacDonald JF, Ascher P (1992) Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J Physiol (Lond) 450:643-672.
58. A receptor subunits: role of the delta subunit. J Neurosci 14:7077-7086.
59. A receptor isoforms. Mol Pharmacol 49:567-579.
60. A receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cells. Neuroscience 62:813-828.
61. A receptor/chloride channel complex in anesthesia. Anesthesiology 78:757-776.
62. 6 subunit. J Neurosci 16:3630-3640.
63. A receptors. Neuropharmacology 35:1375-1382.
64. Tossman U, Jonsson G, Ungerstedt U (1986) Regional distribution and extracellular levels of amino acids in rat central nervous system. Acta Physiol Scand 127:533-545.
65. Trussell LO, Fischbach GD (1989) Glutamate receptor desensitization and its role in synaptic transmission. Neuron 3:209-218.
66. Ueno S, Bracamontes J, Zorumski C, Weiss DS, Steinbach JH (1997) Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci 17:625-634.
67. Verdoorn TA (1994) Formation of heteromeric gamma-aminobutyric acid type A receptors containing two different alpha subunits. Mol Pharmacol 45:475-480.
68. Vicini S, Alho H, Costa E, Mienville JM, Santi MR, Vaccarino FM (1986) Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proc Natl Acad Sci USA 83:9269-9273.
69. 2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 328:640-643.
70. Yang J, Isenberg KE, Zorumski CF (1992) Volatile anesthetics gate a chloride current in postnatal rat hippocampal neurons. FASEB J 6:914-918.
71. A channel deactivation by altering kinetics of desensitized states. J Neurosci 17:4022-4031.