-
1
-
-
0024848781
-
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
-
Burger PM, Mehl E, Cameron P, Maycox P, Baumert M, Lottspeich F, De Camilli P, Jahn R Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels Of glutamate. Neuron 1989, 3:715-720.
-
(1989)
Neuron
, vol.3
, pp. 715-720
-
-
Burger, P.M.1
Mehl, E.2
Cameron, P.3
Maycox, P.4
Baumert, M.5
Lottspeich, F.6
De Camilli, P.7
Jahn, R.8
-
2
-
-
0028846955
-
Anatomy and electrophysiology of fast central synapses lead to a structural model far long-term potentlatlon
-
Edwards FA Anatomy and electrophysiology of fast central synapses lead to a structural model far long-term potentlatlon. Physiol Rev 1995, 75:759-787.
-
(1995)
Physiol Rev
, vol.75
, pp. 759-787
-
-
Edwards, F.A.1
-
3
-
-
0028978441
-
Real-time measurement of transmitter release from single synaptlc vesicles
-
An elegant and direct measurement of release of single synaptic vesicles of transmitter. The authors suggest that small synaptic vesicles can discharge their entire contents (on average -4000 molecules) with a time course faster than their limit of temporal resolution (60-70 μs). In this paper, Figure 2b and the associated inset show directly that the amount of transmitter released varies from one quantum to the next. This implies that if receptors are not saturated, quantunvto-quanlum variance in transmitter concentration will cause quantum-to-quantum variance in postsynaptic current amplitude.
-
Bruns D, Jahn R Real-time measurement of transmitter release from single synaptlc vesicles. Nature 1995, 377:62-65. An elegant and direct measurement of release of single synaptic vesicles of transmitter. The authors suggest that small synaptic vesicles can discharge their entire contents (on average -4000 molecules) with a time course faster than their limit of temporal resolution (60-70 μs). In this paper, Figure 2b and the associated inset show directly that the amount of transmitter released varies from one quantum to the next. This implies that if receptors are not saturated, quantunvto-quanlum variance in transmitter concentration will cause quantum-to-quantum variance in postsynaptic current amplitude.
-
(1995)
Nature
, vol.377
, pp. 62-65
-
-
Bruns, D.1
Jahn, R.2
-
4
-
-
0025087071
-
Konnerth A, Sakmann B: Quarrtal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hlppocampal slices: a patch-clamp study
-
Edwards FA. Konnerth A, Sakmann B: Quarrtal analysis of inhibitory synaptic transmission In the dentate gyrus of rat hlppocampal slices: a patch-clamp study. J Physiol (Lond) 1990,430:213-249.
-
(1990)
J Physiol (Lond)
, vol.430
, pp. 213-249
-
-
Edwards, F.A.1
-
6
-
-
0027282156
-
Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fibre-granule cell synapse
-
Traynelis S, Silver RA, Cull-Candy S Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fibre-granule cell synapse. Neuron 1993, 11:279-289.
-
(1993)
Neuron
, vol.11
, pp. 279-289
-
-
Traynelis, S.1
Silver, R.A.2
Cull-Candy, S.3
-
7
-
-
0028825692
-
Variation in GABA mini * amplitude Is the consequence of variation in transmitter concentration
-
The authors show that a single release event can generate minis both pre- and postsynaptically ai the same time. The two simultaneous minis are strongly correlated in amplitude. This correlation is interpreted as a dependence of the amplitude of both minis on transmitter concentration, indicating that receptors are not Saturated; the authors then independently verify this conclusion using a pharmacological approach. They estimate that the mean degree of receptor occupancy is less than 50%.
-
Frerking M, Borges S, Wilson M Variation In GABA mini * amplitude Is the consequence of variation In transmitter concentration. Neuron 1995, 15:885-895. The authors show that a single release event can generate minis both pre- and postsynaptically ai the same time. The two simultaneous minis are strongly correlated in amplitude. This correlation is interpreted as a dependence of the amplitude of both minis on transmitter concentration, indicating that receptors are not Saturated; the authors then independently verify this conclusion using a pharmacological approach. They estimate that the mean degree of receptor occupancy is less than 50%.
-
(1995)
Neuron
, vol.15
, pp. 885-895
-
-
Frerking, M.1
Borges, S.2
Wilson, M.3
-
8
-
-
0028858391
-
Variation in the number, location and size of synaptic vesicles provides an anatomical basis for the nonunlform probability of release at hlppocampal CA1 synapses
-
Harris KM, Sultan P Variation In the number, location and size of synaptic vesicles provides an anatomical basis for the nonunlform probability of release at hlppocampal CA1 synapses. Neuropharmacology 1995, 34:1387-1395.
-
(1995)
Neuropharmacology
, vol.34
, pp. 1387-1395
-
-
Harris, K.M.1
Sultan, P.2
-
9
-
-
0025529754
-
Synaptic transmission in hlppocampal neurons: Numerical reconstruction of quanta! IPSCs
-
Busch C, Sakmann B Synaptic transmission in hlppocampal neurons: numerical reconstruction of quanta! IPSCs. Cold Spring Harb Symp Quant fl/o/ 1990, 55:69-80.
-
(1990)
Cold Spring Harb Symp Quant Fl/o
, vol.55
, pp. 69-80
-
-
Busch, C.1
Sakmann, B.2
-
10
-
-
0028840270
-
Modeling the effect of glutamate diffusion and * uptake on NMDA and non-NMOA receptor saturation
-
A detailed study that explores the parameter space during release more thoroughly than in other simulations. The author concludes that it is at least possible that, despite their large difference in equilibrium affinity, neither NMDA nor non-NMDA glutamate receptor type is saturated because of rapid diffusion and uptake of transmitter from the synaptic cleft.
-
Holmes WR Modeling the effect of glutamate diffusion and * uptake on NMDA and non-NMOA receptor saturation. Biophys J 1995, 69:1734-1747. A detailed study that explores the parameter space during release more thoroughly than in other simulations. The author concludes that it is at least possible that, despite their large difference in equilibrium affinity, neither NMDA nor non-NMDA glutamate receptor type is saturated because of rapid diffusion and uptake of transmitter from the synaptic cleft.
-
(1995)
Biophys J
, vol.69
, pp. 1734-1747
-
-
Holmes, W.R.1
-
11
-
-
0027070359
-
-
Clements JD, Lester R, Tang G, Jahr C, Weslbrook G: The time course of glutamate In the synaptic cleft Science 1992, 258:1498-1501.
-
(1992)
The Time Course of Glutamate in the Synaptic Cleft Science
, vol.258
, pp. 1498-1501
-
-
Clements, J.D.1
Lester, R.2
Tang, G.3
Jahr, C.4
Weslbrook, G.5
-
12
-
-
0028028527
-
Muttlveslcular release from excitatory synapse of cultured hlppocampal neurons
-
In this extension of an earlier study [11], the authors show that the concentration of transmitter in the cleft is sensitive to changes in the probability of release, but the ratio of non-NMDA- to NMDA-receptor-mediated EPSC amplitude is not. This suggests that both receptors experience the same degree of receptor occupancy. Based on the rapid application of glutamate to excised patches, the authors conclude that both receptor types are probably saturated during release.
-
Tong G, Jahr C Muttlveslcular release from excitatory synapse of cultured hlppocampal neurons. Neuron 1994, 12:51-59. In this extension of an earlier study [11], the authors show that the concentration of transmitter in the cleft is sensitive to changes in the probability of release, but the ratio of non-NMDA- to NMDA-receptor-mediated EPSC amplitude is not. This suggests that both receptors experience the same degree of receptor occupancy. Based on the rapid application of glutamate to excised patches, the authors conclude that both receptor types are probably saturated during release.
-
(1994)
Neuron
, vol.12
, pp. 51-59
-
-
Tong, G.1
Jahr, C.2
-
13
-
-
0028282557
-
Mechanisms shaping glutamate-mediated excitatory postsynaptlc currents in the CNS
-
Jonas P, Spruston N Mechanisms shaping glutamate-mediated excitatory postsynaptlc currents in the CNS. Curr Opin Neurcbiol 1994, 4:369-372.
-
(1994)
Curr Opin Neurcbiol
, vol.4
, pp. 369-372
-
-
Jonas, P.1
Spruston, N.2
-
14
-
-
0028238967
-
Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells
-
Barbour B, Keller B, Llano I, Marty A Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron 1994, 12:1331-1343.
-
(1994)
Neuron
, vol.12
, pp. 1331-1343
-
-
Barbour, B.1
Keller, B.2
Llano, I.3
Marty, A.4
-
15
-
-
0026670868
-
Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hlppocampal slices
-
Jonas P, Sakmann B Glutamate receptor channels In isolated patches from CA1 and CA3 pyramidal cells of rat hlppocampal slices. J Phjfsiol (Land) 1992, 455:143-1 71.
-
(1992)
J Phjfsiol (Land)
, vol.455
, pp. 143-171
-
-
Jonas, P.1
Sakmann, B.2
-
16
-
-
0027081035
-
Action of brief pulses of glutamate on AMPA/kalnate receptors in patches from different neurones of rat hlppocampal slices
-
Colquhoun D, Jonas P, Sakmann B Action of brief pulses of glutamate on AMPA/kalnate receptors In patches from different neurones of rat hlppocampal slices. J Physiol (Land) 1992,458:261-267.
-
(1992)
J Physiol (Land)
, vol.458
, pp. 261-267
-
-
Colquhoun, D.1
Jonas, P.2
Sakmann, B.3
-
18
-
-
0028031943
-
Functional diversity of GABAacttvated CI- Currents in Purkinje versus granule neurons in rat cerebellar slices
-
Puia G, Costa E, Vicini S Functional diversity of GABAacttvated CI- currents In Purkinje versus granule neurons in rat cerebellar slices. Neuron 1994, 12:117-126.
-
(1994)
Neuron
, vol.12
, pp. 117-126
-
-
Puia, G.1
Costa, E.2
Vicini, S.3
-
19
-
-
0028816523
-
Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons
-
Spruston N, Jonas P, Sakmann B Dendritic glutamate receptor channels In rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol (Lond) 1995, 482:325-352.
-
(1995)
J Physiol (Lond)
, vol.482
, pp. 325-352
-
-
Spruston, N.1
Jonas, P.2
Sakmann, B.3
-
20
-
-
0028061339
-
Block of glutamate transporters potentiates ostsynaptlc excitation
-
The authors observe a temperature-dependent increase in miniature and evoked EPSC amplitude in the presence of uptake blockers. A detailed investigation of possible pharmacological artifacts suggests that this effect is genuinely attributable to a decrease in transporter activity. The authors note that the relevant action of the transporters in limiting PSC amplitude need not be uptake per se if the transporters are present in sufficient numbers to buffer rapidly the amount of transmitter released by binding alone. An alternative interpretation of this work has appeared elsewhere [2].
-
Tong G, Jahr C Block of glutamate transporters potentiates spostsynaptlc excitation. Neuron 1994, 13:1195-1203. The authors observe a temperature-dependent increase in miniature and evoked EPSC amplitude in the presence of uptake blockers. A detailed investigation of possible pharmacological artifacts suggests that this effect is genuinely attributable to a decrease in transporter activity. The authors note that the relevant action of the transporters in limiting PSC amplitude need not be uptake per se if the transporters are present in sufficient numbers to buffer rapidly the amount of transmitter released by binding alone. An alternative interpretation of this work has appeared elsewhere [2].
-
(1994)
Neuron
, vol.13
, pp. 1195-1203
-
-
Tong, G.1
Jahr, C.2
-
21
-
-
0029112106
-
a channel responses to brief agonist pulses
-
A channel responses to brief agonist pulses. Neuron 1995, 15:181-191.
-
(1995)
Neuron
, vol.15
, pp. 181-191
-
-
Jones, M.V.1
Westbrook, G.2
-
22
-
-
0027210626
-
Desensltization of AMPA receptors upon muftlquantal neurotransmltter release
-
Trussell U Zhang S, Raman I Desensltization of AMPA receptors upon muftlquantal neurotransmltter release. Neuron 1993, 10:1185-1196.
-
(1993)
Neuron
, vol.10
, pp. 1185-1196
-
-
Trussell, U.1
Zhang, S.2
Raman, I.3
-
23
-
-
0029072339
-
LTP - A structural model to explain the inconsistencies
-
Edwarde FA LTP - a structural model to explain the inconsistencies. Trends Neurosci 1995, 18:250-255.
-
(1995)
Trends Neurosci
, vol.18
, pp. 250-255
-
-
Edwarde, F.A.1
-
24
-
-
0027945483
-
Bridging the cleft at GABA synapses in the brain
-
Mody l, De Koninck Y, Otis T, Soltesz I Bridging the cleft at GABA synapses in the brain. Trends Neurosci 1994, 17:517-525.
-
(1994)
Trends Neurosci
, vol.17
, pp. 517-525
-
-
Mody, L.1
De Koninck, Y.2
Otis, T.3
Soltesz, I.4
-
25
-
-
0026752392
-
The kinetics of the response to glutamate and kainat in neurons of the avlan cochlear nucleus
-
Raman I, Trussell L The kinetics of the response to glutamate and kainat In neurons of the avlan cochlear nucleus. Neuron 1992,9:173-186.
-
(1992)
Neuron
, vol.9
, pp. 173-186
-
-
Raman, I.1
Trussell, L.2
-
26
-
-
0019731782
-
The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group la afférents
-
Jack JJB, Redman SJ, Wong K The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group la afférents. J Physiot (Land) 1981, 321 65-96.
-
(1981)
J Physiot (Land)
, vol.321
, pp. 65-96
-
-
Jjb, J.1
Redman, S.J.2
Wong, K.3
-
27
-
-
0020644355
-
Amplitude fluctuations in synaptic potentials evoked in cat spinal motoneurones at identified group la synapses
-
Redman S, Walmsley B Amplitude fluctuations in synaptic potentials evoked in cat spinal motoneurones at identified group la synapses. J Physiol (Land) 19B3, 343:135-145.
-
(1983)
J Physiol (Land)
-
-
Redman, S.1
Walmsley, B.2
-
28
-
-
0023789059
-
Nonuniform release probabilities underlie quanta! synaptic transmission at a mammalian excitatory central synapse
-
Walmsley B, Edwards FR, Tracey DJ Nonuniform release probabilities underlie quanta! synaptic transmission at a mammalian excitatory central synapse. J Neumphysioi 1988, 60:889-908.
-
(1988)
J Neumphysioi
, vol.60
, pp. 889-908
-
-
Walmsley, B.1
Edwards, F.R.2
Tracey, D.J.3
-
29
-
-
0025906456
-
Quanta! analysis of excitatory synaptic action and depression in hippocampal slices
-
Larkman A, Stratford K, Jack J Quanta! analysis of excitatory synaptic action and depression In hippocampal slices. Nature 1991,350:344-347.
-
(1991)
Nature
, vol.350
, pp. 344-347
-
-
Larkman, A.1
Stratford, K.2
Jack, J.3
-
30
-
-
0026505029
-
Long-term potentJatlon Is associated with increases in quanta content and quanta! amplitude
-
Kullmann DM, Nicoll RA Long-term potentJatlon Is associated with increases in quanta) content and quanta! amplitude. Nature 1992, 357:240-244.
-
(1992)
Nature
, vol.357
, pp. 240-244
-
-
Kullmann, D.M.1
Nicoll, R.A.2
-
31
-
-
0026481883
-
Presynaptic release probability Influences the locus of long-term potentiaiion
-
Larkman A, Hannay T, Stratford K, Jack J Presynaptic release probability Influences the locus of long-term potentiaiion. Nature 1992, 360:70-73.
-
(1992)
Nature
, vol.360
, pp. 70-73
-
-
Larkman, A.1
Hannay, T.2
Stratford, K.3
Jack, J.4
-
32
-
-
0027209740
-
Quanta variability of excitatory transmission in the hippocampus: Implications lor the opening probability of fast glutamate-gated channels
-
Kulimann DM Quanta) variability of excitatory transmission In the hippocampus: Implications lor the opening probability of fast glutamate-gated channels. Proc R Soc Land [Biol] 1903, 253:107-116.
-
(1903)
Proc R Soc Land [Biol]
, vol.253
, pp. 107-116
-
-
Kulimann, D.M.1
-
33
-
-
0027768619
-
Quanta! components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus
-
Jonas P, Major G, Sakmann B Quanta! components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J Physiol (Lond) 1993, 472:615-663.
-
(1993)
J Physiol (Lond)
, vol.472
, pp. 615-663
-
-
Jonas, P.1
Major, G.2
Sakmann, B.3
-
34
-
-
0028692852
-
Quanta! analysis of the synaptic excitation of CA1 hippocampal pyramidal cells
-
Jack JJB, Larkman A, Major G, Stratford K Quanta! analysis of the synaptic excitation of CA1 hippocampal pyramidal cells. In Molecular and Cellular Mechanisms of Neurotransmitter Release, Edited by Stjärne L, Greengard P, Grillner S, Hökfelt T, Ottoeon D. New York: Raven Press, Ltd; 1994:275-299.
-
(1994)
In Molecular and Cellular Mechanisms of Neurotransmitter Release, Edited by Stjärne L, Greengard P, Grillner S, Hökfelt T, Ottoeon D. New York: Raven Press, Ltd
, pp. 275-299
-
-
Jjb, J.1
Larkman, A.2
Major, G.3
Stratford, K.4
-
35
-
-
0028710289
-
Probabilistic secretion of quanta at excitatory synapses on CA1 pyramidal neurons
-
An excellent summary of the latest statistical techniques to détermina the best model to fit to quantal data. In the EPSCs analyzed, the authors conclude that the data ara most parsimoniously described by quantal release with no quantal variance and with no constraints on the nature of the quantal release process.
-
Stricker C, Field A, Redman S Probabilistic secretion of quanta at excitatory synapses on CA1 pyramidal neurons. In Molecular ana Cellular Mechanisms of Neueotransmitter Release. Edited by Stjärne L, Qreengard P, Grillner S, Hökfelt T, Ottoson D. New York: Raven Press, Ltd; 1994:323-340. An excellent summary of the latest statistical techniques to détermina the best model to fit to quantal data. In the EPSCs analyzed, the authors conclude that the data ara most parsimoniously described by quantal release with no quantal variance and with no constraints on the nature of the quantal release process.
-
(1994)
Molecular Ana Cellular Mechanisms of Neueotransmitter Release. Edited by Stjärne L, Qreengard P, Grillner S, Hökfelt T, Ottoson D. New York: Raven Press, Ltd
, pp. 323-340
-
-
Stricker, C.1
Field, A.2
Redman, S.3
-
36
-
-
0028726467
-
Quantal analysis of excitatory postsynaptlc currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse
-
Figure 9 öl this paper shows a nice example of a simulated PSC amplitude distribution with prominent equidistant peaks that are completely unrelated to the release of individual integer numbers of quanta. These peaks are the result of simulated differences in uniquantal amplitude between individual release sites, and illustrate that statistical errors are not the only way in which 'peaky' PSC amplitude distributions can be misinterpreted by quantal analysis.
-
Von Kitzing E, Jonas P, Sakmann B Quantal analysis of excitatory postsynaptlc currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse. In Molecular and Cellular Mechanisms of Neurotmnsmitter Release. Edited by Stjärne L, Greengard P, Grillner S, Hökfelt T, Ottoson D. New York: Raven Press, Ltd; 1994:235-260. Figure 9 öl this paper shows a nice example of a simulated PSC amplitude distribution with prominent equidistant peaks that are completely unrelated to the release of individual integer numbers of quanta. These peaks are the result of simulated differences in uniquantal amplitude between individual release sites, and illustrate that statistical errors are not the only way in which 'peaky' PSC amplitude distributions can be misinterpreted by quantal analysis.
-
(1994)
In Molecular and Cellular Mechanisms of Neurotmnsmitter Release. Edited by Stjärne L, Greengard P, Grillner S, Hökfelt T, Ottoson D. New York: Raven Press, Ltd
, pp. 235-260
-
-
Von Kitzing, E.1
Jonas, P.2
Sakmann, B.3
-
37
-
-
0027949336
-
The quanta! size at retinogenlculate synapses determined from spontaneous and evoked EPSCs in guinea-pig thalamic slices
-
Paulsen O, Heggelund P The quanta! size at retinogenlculate synapses determined from spontaneous and evoked EPSCs in guinea-pig thalamic slices. J Physiol (Lond) 1994, 480:505-511.
-
(1994)
J Physiol (Lond)
, vol.480
, pp. 505-511
-
-
Paulsen, O.1
Heggelund, P.2
-
38
-
-
0028902849
-
Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures
-
Bekkers JM, Stevens CF Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures. J Neuropkysiol 1995, 73:1145-1156.
-
(1995)
J Neuropkysiol
, vol.73
, pp. 1145-1156
-
-
Bekkers, J.M.1
Stevens, C.F.2
-
39
-
-
0027234184
-
Occurrence and three-dimensional structura of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1
-
Sorra K, Harris K Occurrence and three-dimensional structura of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. JA/aurasc/1993, 13:3736-3748.
-
(1993)
JA/aurasc
, vol.13
, pp. 3736-3748
-
-
Sorra, K.1
Harris, K.2
-
40
-
-
0028845482
-
Counting quanta: Direct measurements of transmitter release at a central synapse
-
This report is an in situ test of the predictions of quantal analysis. By reducing release with low concentrations of Cd2+. the authors show that the distribution of uniquantal responses has much more variance than recent quantal analyses predict and is similar in shape to the mini distribution.
-
Isaacson J, Walmsley B Counting quanta: direct measurements of transmitter release at a central synapse. Neuron 1995, 15:875-884. This report is an in situ test of the predictions of quantal analysis. By reducing release with low concentrations of Cd2+. the authors show that the distribution of uniquantal responses has much more variance than recent quantal analyses predict and is similar in shape to the mini distribution.
-
(1995)
Neuron
, vol.15
, pp. 875-884
-
-
Isaacson, J.1
Walmsley, B.2
-
41
-
-
0025150653
-
Origin of variability in quantal si in cultured hippocampal neurons and hippocampal slices
-
Bekkers JM, Richerson G, Stevens CF Origin of variability in quantal si in cultured hippocampal neurons and hippocampal slices. Proc Nail Acad Sci USA 1990, 87:5359-5362.
-
(1990)
Proc Nail Acad Sci USA
, vol.87
, pp. 5359-5362
-
-
Bekkers, J.M.1
Richerson, G.2
Stevens, C.F.3
-
42
-
-
0029061895
-
Properties of synaptic transmission at single hippocampal synaptlc boutons
-
The authors use a combination of imaging, pharmacology, and electrophysiology to isolate with high reliability the minis from single synaptic boutons. As in the previous report, the authors conclude that most or all variance in mini amplitude is probably attributable to sources of variance intrinsic to each release site In addition, the authors provide evidence that mean mini amplitude at an input is determined by the innervation density on the postsynaptic cell, calling into question the popular assumption that different inputs must have different uniquantal amplitudes.
-
Liu G, Tsien RW Properties of synaptic transmission at single hippocampal synaptlc boutons. Nature 1995, 375:404-408. The authors use a combination of imaging, pharmacology, and electrophysiology to isolate with high reliability the minis from single synaptic boutons. As in the previous report, the authors conclude that most or all variance in mini amplitude is probably attributable to sources of variance intrinsic to each release site In addition, the authors provide evidence that mean mini amplitude at an input is determined by the innervation density on the postsynaptic cell, calling into question the popular assumption that different inputs must have different uniquantal amplitudes.
-
(1995)
Nature
, vol.375
, pp. 404-408
-
-
Liu, G.1
Tsien, R.W.2
-
43
-
-
0026543060
-
Putative single quantum and single fibre excitatory postsynaptic currents show similar amplitude range and variability in rat hippocampal slices
-
Raastad M, Storm J, Andersen P Putative single quantum and single fibre excitatory postsynaptic currents show similar amplitude range and variability In rat hippocampal slices. Eur J Neurosci 1992, 4:113-117.
-
(1992)
Eur J Neurosci
, vol.4
, pp. 113-117
-
-
Raastad, M.1
Storm, J.2
Andersen, P.3
-
44
-
-
0028957942
-
Facilitation and depression at single central synapses
-
Stevens CF, Wang Y Facilitation and depression at single central synapses. Neuron 1995, 14:795-802.
-
(1995)
Neuron
, vol.14
, pp. 795-802
-
-
Stevens, C.F.1
Wang, Y.2
-
45
-
-
0027053351
-
Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions
-
Faber DS, Young W, Legendre P, Korn H Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions. Science 1992, 258:1494-1496.
-
(1992)
Science
, vol.258
, pp. 1494-1496
-
-
Faber, D.S.1
Young, W.2
Legendre, P.3
Korn, H.4
-
46
-
-
0029091330
-
Interpretation of 'quantal' peaks in distributions of evoked synaptic transmission at central synapses
-
Walmsley B Interpretation of 'quantal' peaks In distributions of evoked synaptic transmission at central synapses. Proc R Soc Land [Bioll 1995, 261:245-250.
-
(1995)
Proc R Soc Land Bioll
, vol.261
, pp. 245-250
-
-
Walmsley, B.1
-
47
-
-
0029925447
-
Effects of variance in mini amplitude on stimulus-evoked release: A comparison of two models
-
Frerking M, Wilson M Effects of variance In mini amplitude on stimulus-evoked release: a comparison of two models. Biophys J 1996, 70:2078-2091.
-
(1996)
Biophys J
, vol.70
, pp. 2078-2091
-
-
Frerking, M.1
Wilson, M.2
-
49
-
-
0027745979
-
Hippocampal pyramidal cells excite inhibitory neurons through a single release site
-
Gulyas A, Miles R, Sik A, Tbth K, Tamamaki N, Freund T Hippocampal pyramidal cells excite inhibitory neurons through a single release site. Nature 1993, 366:683-687.
-
(1993)
Nature
, vol.366
, pp. 683-687
-
-
Gulyas, A.1
Miles, R.2
Sik, A.3
Tbth, K.4
Tamamaki, N.5
Freund, T.6
-
50
-
-
0029947040
-
Non-NMDA glutamate sreceptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites
-
in press. The authors describe two types of synaptic responses isolated by minimal stimulation: the first has a high coefficient of variation (CV), a low amplitude, and a rapid decay; and the second has a low CV, a high amplitude, and a slow decay. This suggests that one type of synapse is not saturated and the other is. The high CV response originates from synapses with a single release site, and the authors estimate receptor occupancy to be -50%. The low CV synapses have a reduced mean postsynaptic current (PSC) amplitude and faster decay when the probability of release is depressed, suggesting that these synapses have multiple release sites, and that 'spill-over' of transmitter from one site to the next is the cause of saturation at those synapses. This indicates that the number of release sites at the synapse is likely to be important in determining the degree of receptor occupancy.
-
Silver RA, Cull-Candy S, Takahashi T Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. J Physio! (Lond) 1996, in press. The authors describe two types of synaptic responses isolated by minimal stimulation: the first has a high coefficient of variation (CV), a low amplitude, and a rapid decay; and the second has a low CV, a high amplitude, and a slow decay. This suggests that one type of synapse is not saturated and the other is. The high CV response originates from synapses with a single release site, and the authors estimate receptor occupancy to be -50%. The low CV synapses have a reduced mean postsynaptic current (PSC) amplitude and faster decay when the probability of release is depressed, suggesting that these synapses have multiple release sites, and that 'spill-over' of transmitter from one site to the next is the cause of saturation at those synapses. This indicates that the number of release sites at the synapse is likely to be important in determining the degree of receptor occupancy.
-
(1996)
J Physio! (Lond)
-
-
Silver, R.A.1
Cull-Candy, S.2
Takahashi, T.3
-
51
-
-
0024473444
-
Dendritic spines of CA1 pyramidal cells in the rat hippocampus: Serial electron microscopy with reference to their biophysical characteristics
-
Harris K, Stevens JK Dendritic spines of CA1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J Neurose! 1989, 9:2982-2997.
-
(1989)
J Neurose!
, vol.9
, pp. 2982-2997
-
-
Harris, K.1
Stevens, J.K.2
-
52
-
-
0028694789
-
The oneveside hypothesis and muftlveslcular release
-
The authors argue that a coordination of multiple release sites within individual synaptic boutons leads to a large number ot multiquantal events in the mini distribution. They make the interesting observation that the distribution of active zones per synaptic bouton matches the number of multiquantal events in the mini distribution implied on the basis of maximum likelihood estimation. If the correlation suggested by this observation existe, the probability of release in a bouton must spontaneously switch between zero and one for all sites in the bouton simultaneously.
-
Korn H, Sur C, Charpier S, Legendre P, Faber DS The oneveside hypothesis and muftlveslcular release. In Molecular and Cellular Mechanisms of Neurotransmitter Release. Edited by Stjärne L, Greengard P, Grillner S, Hokfelt T, Ottoson D. New York: Raven Press, Ltd; 1994:301-322. The authors argue that a coordination of multiple release sites within individual synaptic boutons leads to a large number ot multiquantal events in the mini distribution. They make the interesting observation that the distribution of active zones per synaptic bouton matches the number of multiquantal events in the mini distribution implied on the basis of maximum likelihood estimation. If the correlation suggested by this observation existe, the probability of release in a bouton must spontaneously switch between zero and one for all sites in the bouton simultaneously.
-
(1994)
In Molecular and Cellular Mechanisms of Neurotransmitter Release. Edited by Stjärne L, Greengard P, Grillner S, Hokfelt T, Ottoson D. New York: Raven Press, Ltd
, pp. 301-322
-
-
Korn, H.1
Sur, C.2
Charpier, S.3
Legendre, P.4
Faber, D.S.5
-
53
-
-
0026063649
-
Nonstationary fluctuation analysis and direct resolution of single channel currents at postsynaptic sites
-
Robinson HPC, Sahara Y, Kawai N Nonstationary fluctuation analysis and direct resolution of single channel currents at postsynaptic sites. Biophys J 1991, 59:295-304.
-
(1991)
Biophys J
, vol.59
, pp. 295-304
-
-
Robinson, H.P.C.1
Sahara, Y.2
Kawai, N.3
-
54
-
-
0028210896
-
Noise analysis of miniature IPSCs in adult rat brain slices: Properties and modulation of synaptic GABAA receptor channels
-
De Koninck Y, Mod/ I Noise analysis of miniature IPSCs In adult rat brain slices: properties and modulation of synaptic GABAA receptor channels. J Neurophysiol 1994, 71:1318-1335.
-
(1994)
J Neurophysiol
, vol.71
, pp. 1318-1335
-
-
De Koninck, Y.1
Mod, I.2
-
55
-
-
0028136698
-
Lasting potentlatlon of Inhibition is associated with an increased number of -y-arninobutyrlc add type a receptors activated during miniature inhibitory postsynaptic currants
-
Otis T, De Koninck Y, Mody I Lasting potentlatlon of Inhibition is associated with an increased number of -y-arninobutyrlc add type A receptors activated during miniature inhibitory postsynaptic currants. Proc Natl Acad Sci USA 1994, 91:7698-7702.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7698-7702
-
-
Otis, T.1
De Koninck, Y.2
Mody, I.3
-
56
-
-
0024521636
-
Augmentation of GABAinduced chloride current in frog sensory neurons by dlazepam
-
Yakushiji T, Tokulomi N, Akaike N Augmentation of GABAinduced chloride current in frog sensory neurons by dlazepam. Neurosci Res 1989, 6:309-320.
-
(1989)
Neurosci Res
, vol.6
, pp. 309-320
-
-
Yakushiji, T.1
Tokulomi, N.2
Akaike, N.3
-
57
-
-
0028181698
-
Benzodlazeplne and -carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture
-
Rogers C, Twyman R, Macdonald R Benzodlazeplne and -carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture. J Physiol (iond) 1994, 475:69-82.
-
(1994)
J Physiol (Iond)
, vol.475
, pp. 69-82
-
-
Rogers, C.1
Twyman, R.2
Macdonald, R.3
-
58
-
-
0021131778
-
Rat hippocampal neurons in culture: Voltage-clamp analysis of inhibitory synaptic connections
-
Segal M, Barker J Rat hippocampal neurons in culture: voltage-clamp analysis of inhibitory synaptic connections. J Neurophysiol 1984, 52:469-487.
-
(1984)
J Neurophysiol
, vol.52
, pp. 469-487
-
-
Segal, M.1
Barker, J.2
-
59
-
-
0026697352
-
a receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons
-
A receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons. Neuroscience 1992, 49:13-32.
-
(1992)
Neuroscience
, vol.49
, pp. 13-32
-
-
Otis, T.1
Mody, I.2
-
60
-
-
0027369524
-
The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus
-
Isaacson JS, Nicoll RA The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents In the hippocampus. J Neurophysiol-\9Q3, 70:2187-2191.
-
J Neurophysiol-\9Q3, 70
, vol.70
, pp. 2187-2191
-
-
Isaacson, J.S.1
Nicoll, R.A.2
-
61
-
-
0027375540
-
Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current
-
Sarantis M, Ballerini L, Miller B, Silver RA, Edwards M, Atlwell D: Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current Neuron 1993, 11:541-549.
-
(1993)
Neuron
, vol.11
, pp. 541-549
-
-
Sarantis, M.1
Ballerini, L.2
Miller, B.3
Silver, R.A.4
Edwards, M.5
Atlwell, D.6
-
62
-
-
0028569213
-
Saturation of postsynaptlc glutamate receptors after quanta! release of transmitter
-
The authors demonstrate that when two minis are released in rapid succession, the amplitude of the second mini is smaller than that of the first. This implies that a high degree of receptor occupancy takes place during the first mini, supporting receptor saturation in the presence of cyclothiazide. The authors also note the presence of occasional bursts of high-amplitude, low coefficient ol variation (CV) minis, much like the evoked output of the multisite synapses reported elsewhere [50**].
-
Tang C-M, Margulis M, Shi u-Y, Fialding A Saturation of postsynaptlc glutamate receptors after quanta! release of transmitter. Neuron 1994, 13:1385-1393. The authors demonstrate that when two minis are released in rapid succession, the amplitude of the second mini is smaller than that of the first. This implies that a high degree of receptor occupancy takes place during the first mini, supporting receptor saturation in the presence of cyclothiazide. The authors also note the presence of occasional bursts of high-amplitude, low coefficient ol variation (CV) minis, much like the evoked output of the multisite synapses reported elsewhere [50**].
-
(1994)
Neuron
, vol.13
, pp. 1385-1393
-
-
Tang, C.-M.1
Margulis, M.2
Fialding, A.3
-
63
-
-
0027228511
-
Hippocampal murons exhibit cydpthlazide-sensltlve rapidly desensitizing responses to kainate
-
Patneau D, Vyklicky L, Mayer M Hippocampal murons exhibit cydpthlazide-sensltlve rapidly desensitizing responses to kainate. J Neurose! 1993, 13:3496-3509.
-
(1993)
J Neurose!
, vol.13
, pp. 3496-3509
-
-
Patneau, D.1
Vyklicky, L.2
Mayer, M.3
-
64
-
-
0027209412
-
Benzothladlazldes inhibit rapid glutamate receptor desensiUzatlon and enhance glutamatergic synapüc currents
-
Yamada K, Tang C-M Benzothladlazldes inhibit rapid glutamate receptor desensiUzatlon and enhance glutamatergic synapüc currents. J Neurosci 1993,13:3904-3915.
-
(1993)
J Neurosci
, vol.13
, pp. 3904-3915
-
-
Yamada, K.1
Tang, C.-M.2
-
65
-
-
0028792374
-
Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC
-
Cyclothiazide users, beware! This report shows triat cyclothiazide affects not only the kinetics of the AMPA receptor but also that of NMDA receptors, and may even affect the probability of release.
-
Diamond J, Jahr C Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC. Neuron 1995, 15:1097-1107. Cyclothiazide users, beware! This report shows triat cyclothiazide affects not only the kinetics of the AMPA receptor but also that of NMDA receptors, and may even affect the probability of release.
-
(1995)
Neuron
, vol.15
, pp. 1097-1107
-
-
Diamond, J.1
Jahr, C.2
-
66
-
-
0028169225
-
Fast presynaptic GABAA receptor-mediated CI conductance in cultured rat hippocampnl neurones
-
Vautrin J, Schaffner A, Barker J Fast presynaptic GABAA receptor-mediated CI conductance in cultured rat hippocampnl neurones. J Physio! (Land) 1994, 479:53-63.
-
(1994)
J Physio! (Land)
, vol.479
, pp. 53-63
-
-
Vautrin, J.1
Schaffner, A.2
Barker, J.3
|